ID A0A1X1QZC4_MYCFA Unreviewed; 417 AA.
AC A0A1X1QZC4;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=3-oxoacyl-ACP synthase {ECO:0000313|EMBL:BBY97897.1};
DE SubName: Full=Beta-ketoacyl-[acyl-carrier-protein] synthase II {ECO:0000313|EMBL:ORU96748.1};
GN ORFNames=AWC04_19455 {ECO:0000313|EMBL:ORU96748.1}, MFAL_13640
GN {ECO:0000313|EMBL:BBY97897.1};
OS Mycolicibacterium fallax (Mycobacterium fallax).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1793 {ECO:0000313|EMBL:ORU96748.1, ECO:0000313|Proteomes:UP000193484};
RN [1] {ECO:0000313|EMBL:ORU96748.1, ECO:0000313|Proteomes:UP000193484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44179 {ECO:0000313|EMBL:ORU96748.1,
RC ECO:0000313|Proteomes:UP000193484};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBY97897.1, ECO:0000313|Proteomes:UP000467101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY97897.1,
RC ECO:0000313|Proteomes:UP000467101};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBY97897.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY97897.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism; mycolic acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004796}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
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DR EMBL; AP022603; BBY97897.1; -; Genomic_DNA.
DR EMBL; LQOJ01000073; ORU96748.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1QZC4; -.
DR STRING; 1793.AWC04_19455; -.
DR KEGG; mfx:MFAL_13640; -.
DR OrthoDB; 9808669at2; -.
DR UniPathway; UPA00915; -.
DR Proteomes; UP000193484; Unassembled WGS sequence.
DR Proteomes; UP000467101; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProt.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022516};
KW Reference proteome {ECO:0000313|Proteomes:UP000193484};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 10..416
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 417 AA; 43764 MW; C22AA2D132864A3A CRC64;
MASPTTGNGL PNVVVTGVAM TTALGTDAET TWKNLLDGQS GIRTLTDSFI EEYDLPVRIG
GHLLEDFDGE LNKVELRRMS YLQKMATVLG RRVWQNAGSP EVDTNRLMVS VGTGLGSAEE
LVWAYDGMRS RGLRAVSPLV VQMYMPNGAA AVIGLERGAK AGVSTSISAC ASGSEAIANA
WRNIVYGEAD IAICGGVETK IEAVPIAGFA QMRIVLSSHN DDPPGACRPF DRDRSGFVFG
EGGALLVIET EEHAKARGAN ILARIMGASV TSDGFHMVAP DPNGERAGHA MSRAIELAGL
QPTDIDHINA HATGTSVGDV AEGKAINNAM RGHRPAVYAP KSALGHSVGA VGAVESILTV
QALRDGIIPA TRNLENLDPE IDLDVVAGAP RTGDYKYAIN NSFGFGGHNV AIAFGKY
//