ID A0A1X1RIC8_MYCFA Unreviewed; 468 AA.
AC A0A1X1RIC8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=amidase {ECO:0000256|ARBA:ARBA00012922};
DE EC=3.5.1.4 {ECO:0000256|ARBA:ARBA00012922};
GN Name=amiC {ECO:0000313|EMBL:BBY96815.1};
GN ORFNames=AWC04_05200 {ECO:0000313|EMBL:ORV06834.1}, MFAL_02820
GN {ECO:0000313|EMBL:BBY96815.1};
OS Mycolicibacterium fallax (Mycobacterium fallax).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=1793 {ECO:0000313|EMBL:ORV06834.1, ECO:0000313|Proteomes:UP000193484};
RN [1] {ECO:0000313|EMBL:ORV06834.1, ECO:0000313|Proteomes:UP000193484}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44179 {ECO:0000313|EMBL:ORV06834.1,
RC ECO:0000313|Proteomes:UP000193484};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBY96815.1, ECO:0000313|Proteomes:UP000467101}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY96815.1,
RC ECO:0000313|Proteomes:UP000467101};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBY96815.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 6405 {ECO:0000313|EMBL:BBY96815.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a monocarboxylic acid amide + H2O = a monocarboxylate +
CC NH4(+); Xref=Rhea:RHEA:12020, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:35757, ChEBI:CHEBI:83628; EC=3.5.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001311};
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DR EMBL; AP022603; BBY96815.1; -; Genomic_DNA.
DR EMBL; LQOJ01000020; ORV06834.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1RIC8; -.
DR STRING; 1793.AWC04_05200; -.
DR KEGG; mfx:MFAL_02820; -.
DR OrthoDB; 5175573at2; -.
DR Proteomes; UP000193484; Unassembled WGS sequence.
DR Proteomes; UP000467101; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR Gene3D; 3.90.1300.10; Amidase signature (AS) domain; 1.
DR InterPro; IPR000120; Amidase.
DR InterPro; IPR020556; Amidase_CS.
DR InterPro; IPR023631; Amidase_dom.
DR InterPro; IPR036928; AS_sf.
DR PANTHER; PTHR11895:SF180; AMIDASE AMIC-RELATED; 1.
DR PANTHER; PTHR11895; TRANSAMIDASE; 1.
DR Pfam; PF01425; Amidase; 1.
DR SUPFAM; SSF75304; Amidase signature (AS) enzymes; 1.
DR PROSITE; PS00571; AMIDASES; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000193484}.
FT DOMAIN 33..450
FT /note="Amidase"
FT /evidence="ECO:0000259|Pfam:PF01425"
SQ SEQUENCE 468 AA; 49519 MW; 16CFDD53F534E137 CRC64;
MASVHAFGDD ALSDLDAVGA VQALRRGAVS AAELAEAAIA RTERVNPDLN GLALATFDRA
RAQAADPGAG HFAGVPSFIK DNTDVAGLPT MQGTDAWAPT PAPVHGDFAR MFLGTGLNIL
GKTQMSEFGF SAACEHPRLG AVRNPWDPSR TAGASSSGSG ALVAAGAVPI AHANDGGGSI
RIPASCNGLV GLKPSRGRLP LEAAHAEMPI KIVANGVLSR SVRDTAAFYR EAEIAWANPK
LPPIGDITGP GRRRLRIAVT TRSIRRESAP EVCAATLRTA ALLEELGHHV EQLDELPVPD
NFVDDFVLYW SLLSMALVRS GRRRFGPSFD PARLDNLSRG LDRHAARNLH RLPLAIARLA
LTRRRTAALY HRFDVVLTPT LADQPPAVGH LDPMADYAQI IDRLIDWVAF TPLHNITGEP
AISLPLARSA AGLPIGMMFG APLGADASLL ELAYQLEAAA PFARIQDG
//
