ID A0A1X1RQP8_MYCCE Unreviewed; 586 AA.
AC A0A1X1RQP8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Short-chain dehydrogenase {ECO:0000313|EMBL:ORV12683.1, ECO:0000313|EMBL:PIB80960.1};
GN ORFNames=AWB95_12295 {ECO:0000313|EMBL:ORV12683.1}, CQY23_01660
GN {ECO:0000313|EMBL:PIB80960.1};
OS Mycobacterium celatum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=28045 {ECO:0000313|EMBL:ORV12683.1, ECO:0000313|Proteomes:UP000193907};
RN [1] {ECO:0000313|EMBL:ORV12683.1, ECO:0000313|Proteomes:UP000193907}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44243 {ECO:0000313|EMBL:ORV12683.1,
RC ECO:0000313|Proteomes:UP000193907};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PIB80960.1, ECO:0000313|Proteomes:UP000230971}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 12882 {ECO:0000313|EMBL:PIB80960.1,
RC ECO:0000313|Proteomes:UP000230971};
RX PubMed=29030295; DOI=10.1016/j.meegid.2017.10.013;
RA Tortoli E., Fedrizzi T., Meehan C.J., Trovato A., Grottola A.,
RA Giacobazzi E., Serpini G.F., Tagliazucchi S., Fabio A., Bettua C.,
RA Bertorelli R., Frascaro F., De Sanctis V., Pecorari M., Jousson O.,
RA Segata N., Cirillo D.M.;
RT "The new phylogeny of the genus Mycobacterium: The old and the news.";
RL Infect. Genet. Evol. 56:19-25(2017).
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORV12683.1}.
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DR EMBL; LQOM01000028; ORV12683.1; -; Genomic_DNA.
DR EMBL; PDKV01000001; PIB80960.1; -; Genomic_DNA.
DR STRING; 28045.AWB95_12295; -.
DR OrthoDB; 4220752at2; -.
DR Proteomes; UP000193907; Unassembled WGS sequence.
DR Proteomes; UP000230971; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43391:SF12; OXIDOREDUCTASE EPHD-RELATED; 1.
DR PANTHER; PTHR43391; RETINOL DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..281
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 586 AA; 63904 MW; 8B7B3CD16FCAA63D CRC64;
MAAPQRFVDS ADGVRLAVCE EGKADGPTVV LVHGWPDSHV LWDGVVPLLA ERFRVVRYDN
RGVGGSSAPK RVSAYTMARF ADDFAAVVDA CSSGRPVHVL AHDWGSVGVW EYLSRPGAGK
RVASFTSVSG PSQDHLVDYI FTGLRRPHRP RTFVRALSQA LRLTYMAFFS IPVLAPLFIR
AALSSAAIRR RLVDNVPVEQ IHHSDTMAAD AARSLKTYRA NYFRSFAHHR HDHYVDVPVQ
LVVNTEDRYV RPYGYDATAR WVPRLWRRDI KAGHWSPMSH PQVLAAAVHE LADFTEGKPP
CRALRRAQVG PRRDYFTDML VSVTGAGSGI GRATAFAFSR EGAEVVVSDI DDAAVKDTAA
EIAAAGGVAH AYQLDVADAE AVEAFAEQVC AEYGVPDIVV NNAGIGQAGR FLDTPPEQFD
RVLGVNFGGV VNGCRAFARR LVERGAGGHI VNVSSMAAYA PSQQLNAYCT SKAAVYMFSD
CLRAELDAAG VGLTTICPGV IDTNIVHTTR FDAPSGHIEQ AEGRRAQLEK MFALRRYTPD
KVADAIIAAV KKNKAIRPVA PEAYLLYGVS RWAPQVLRST ARRRLV
//
