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Database: UniProt
Entry: A0A1X1SYQ6_9MYCO
LinkDB: A0A1X1SYQ6_9MYCO
Original site: A0A1X1SYQ6_9MYCO 
ID   A0A1X1SYQ6_9MYCO        Unreviewed;       340 AA.
AC   A0A1X1SYQ6;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989, ECO:0000256|HAMAP-Rule:MF_00955};
DE            EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989, ECO:0000256|HAMAP-Rule:MF_00955};
DE   AltName: Full=GDP-D-mannose dehydratase {ECO:0000256|HAMAP-Rule:MF_00955};
GN   Name=gmdA {ECO:0000313|EMBL:BBZ39215.1};
GN   Synonyms=gmd {ECO:0000256|HAMAP-Rule:MF_00955};
GN   ORFNames=MCNS_22780 {ECO:0000313|EMBL:BBZ39215.1};
OS   Mycobacterium conspicuum.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=44010 {ECO:0000313|EMBL:BBZ39215.1, ECO:0000313|Proteomes:UP000467385};
RN   [1] {ECO:0000313|EMBL:BBZ39215.1, ECO:0000313|Proteomes:UP000467385}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 14738 {ECO:0000313|EMBL:BBZ39215.1,
RC   ECO:0000313|Proteomes:UP000467385};
RA   Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA   Iida T., Fujita J., Nakamura S.;
RT   "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT   species based on 7547 genomic profiles.";
RL   Emerg. Microbes Infect. 8:1043-1053(2019).
CC   -!- FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-
CC       deoxy-D-mannose. {ECO:0000256|HAMAP-Rule:MF_00955}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O;
CC         Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:57964; EC=4.2.1.47; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00955};
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00001937,
CC         ECO:0000256|HAMAP-Rule:MF_00955};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily.
CC       {ECO:0000256|ARBA:ARBA00009263, ECO:0000256|HAMAP-Rule:MF_00955}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00955}.
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DR   EMBL; AP022613; BBZ39215.1; -; Genomic_DNA.
DR   STRING; 44010.AWC00_23985; -.
DR   OrthoDB; 9779041at2; -.
DR   Proteomes; UP000467385; Chromosome.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0070401; F:NADP+ binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR   CDD; cd05260; GDP_MD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   HAMAP; MF_00955; GDP_Man_dehydratase; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR01472; gmd; 1.
DR   PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR   PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00955};
KW   NADP {ECO:0000256|HAMAP-Rule:MF_00955}.
SQ   SEQUENCE   340 AA;  38242 MW;  07E5CEAC53FB8FF9 CRC64;
     MKRALIAGIT GQDGSYLAEL LLSKGYEVHG LIRRASTFNT SRIDHLYVDP HQTDARLFLH
     YGDLTDGTRL VTLLSTIDPD EVYNLAAQSH VRVSFDEPVH TGDTTGMGSI RLLEAVRLSK
     IGCRFYQASS SEMYGATPPP QNEQTPFYPR SPYGAAKVYS YWATRNYREA YDLFAVNGIL
     FNHESPRRGE TFVTRKITRA VARIKAGVQS ELFMGNLDAV RDWGYAPEYV EGMWRMLQAP
     EPEDYVLATG RGYTVREFAQ TAFDHVGLDW QKYVKFDERY LRPTEVDALI GDASKAAQSL
     GWKACVHTAE LARIMVDADM AALECDGTPW IDKPMLPGWS
//
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