ID A0A1X1T2Z1_9MYCO Unreviewed; 626 AA.
AC A0A1X1T2Z1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=NADH-quinone oxidoreductase subunit L {ECO:0000313|EMBL:BBZ06896.1};
DE SubName: Full=NADH:ubiquinone oxidoreductase subunit L {ECO:0000313|EMBL:ORV38710.1};
GN Name=nuoL {ECO:0000313|EMBL:BBZ06896.1};
GN ORFNames=AWC01_14275 {ECO:0000313|EMBL:ORV38710.1}, MDOR_10650
GN {ECO:0000313|EMBL:BBZ06896.1};
OS Mycolicibacterium doricum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=126673 {ECO:0000313|EMBL:ORV38710.1, ECO:0000313|Proteomes:UP000193564};
RN [1] {ECO:0000313|EMBL:ORV38710.1, ECO:0000313|Proteomes:UP000193564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44339 {ECO:0000313|EMBL:ORV38710.1,
RC ECO:0000313|Proteomes:UP000193564};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBZ06896.1, ECO:0000313|Proteomes:UP000467201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12405 {ECO:0000313|EMBL:BBZ06896.1,
RC ECO:0000313|Proteomes:UP000467201};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBZ06896.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 12405 {ECO:0000313|EMBL:BBZ06896.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU000320}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU000320}.
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DR EMBL; AP022605; BBZ06896.1; -; Genomic_DNA.
DR EMBL; LQOS01000040; ORV38710.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1T2Z1; -.
DR STRING; 126673.AWC01_14275; -.
DR KEGG; mdr:MDOR_10650; -.
DR OrthoDB; 9811798at2; -.
DR Proteomes; UP000193564; Unassembled WGS sequence.
DR Proteomes; UP000467201; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR Gene3D; 1.20.5.2700; -; 1.
DR InterPro; IPR018393; NADHpl_OxRdtase_5_subgr.
DR InterPro; IPR001750; ND/Mrp_mem.
DR InterPro; IPR003945; NU5C-like.
DR InterPro; IPR001516; Proton_antipo_N.
DR NCBIfam; TIGR01974; NDH_I_L; 1.
DR PANTHER; PTHR42829; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR PANTHER; PTHR42829:SF2; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 5; 1.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR Pfam; PF00662; Proton_antipo_N; 1.
DR PRINTS; PR01434; NADHDHGNASE5.
DR PRINTS; PR01435; NPOXDRDTASE5.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000193564};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000320};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubiquinone {ECO:0000313|EMBL:ORV38710.1}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 32..53
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 118..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..203
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..521
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 69..119
FT /note="NADH-Ubiquinone oxidoreductase (complex I) chain 5
FT N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00662"
FT DOMAIN 135..418
FT /note="NADH:quinone oxidoreductase/Mrp antiporter membrane
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF00361"
SQ SEQUENCE 626 AA; 64668 MW; E459FC0D0344AC00 CRC64;
MTTGVWLLIA LPLAGAVVLL LAGRRSDRWG HLLATAASVA SFVVGAVLFT GMLGRAAEDR
AVHETLFSWV PVGELQVDFG LQLDQLSMCF VLLITGVGSL IHVYSIGYMA HDPGKRRFFA
YLNLFLAAML LLVLADNYLG LYVGWEGVGL ASYLLIGFWS DKPSAATAAK KAFIVNRVGD
TGLAIALMIM FATVGSVSFA GVFGAASQLG EGTLTAIGLL LLLGACGKSA QVPLQSWLGD
AMEGPTPVSA LIHAATMVTA GVYLIVRSGP VFDLAPTAQL GVVIVGTVTL LFGAIIGCAK
DDIKKALAAS TMSQIGYMVL AAGLGPAGYA FAIMHLLTHG FFKAGLFLGA GSVMHAMDDE
VNMRRYGGLR KALPITFATF GLGYLAIIGV PPLAGFFSKD GIIEAALGAG GVKGWFLGGA
AILGAGITAF YMTRVMLMTF FGEKRWAEGV RPHEAPAVMT APMVVLAIGS VASGGLLAVG
GTLSHWLEPV VGTHEEAHAV PVVVATAVIL SVVAVGIAVA YRTYATRAVP ADVPAGSALT
VAARRDLYGD ALNEAVFMRP GQVVTAGMVS VDDRAVDGAA TGLATLVART SDGLRRLQTG
LARSYALGML GGAALVVAAI LVVNLW
//
