ID A0A1X1TAD5_9MYCO Unreviewed; 593 AA.
AC A0A1X1TAD5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Signal peptide peptidase SppA {ECO:0000313|EMBL:BBZ37558.1};
GN Name=sppA {ECO:0000313|EMBL:BBZ37558.1};
GN ORFNames=AWC00_14830 {ECO:0000313|EMBL:ORV41479.1}, MCNS_06210
GN {ECO:0000313|EMBL:BBZ37558.1};
OS Mycobacterium conspicuum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=44010 {ECO:0000313|EMBL:BBZ37558.1, ECO:0000313|Proteomes:UP000467385};
RN [1] {ECO:0000313|EMBL:ORV41479.1, ECO:0000313|Proteomes:UP000193407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44136 {ECO:0000313|EMBL:ORV41479.1,
RC ECO:0000313|Proteomes:UP000193407};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBZ37558.1, ECO:0000313|Proteomes:UP000467385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 14738 {ECO:0000313|EMBL:BBZ37558.1,
RC ECO:0000313|Proteomes:UP000467385};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBZ37558.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 14738 {ECO:0000313|EMBL:BBZ37558.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
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DR EMBL; AP022613; BBZ37558.1; -; Genomic_DNA.
DR EMBL; LQOR01000031; ORV41479.1; -; Genomic_DNA.
DR STRING; 44010.AWC00_14830; -.
DR OrthoDB; 9764363at2; -.
DR Proteomes; UP000193407; Unassembled WGS sequence.
DR Proteomes; UP000467385; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 107..259
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 373..524
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 175
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 390
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 593 AA; 62477 MW; 3C5246EA060CBBD1 CRC64;
MFGFLPSLPG VDDVRDLVYR VDTARHHGIP SGCVLELDLR SAPPETTGFD PLTIVTGGGR
AMALRDAVAA IHRAAQDPRV AGMIARVQLA ASPVGAVQEL REAIAAFTAV KPSLAWAETY
PGTLSYYLAS AFGEVWMQPS GSVGLIGFAS SATFLRDALD KAGIEAQFTA RGEYKSAANL
FTQAQFTEAH REAVTRMLDS LQEQVWQAVA ESRHIDAGAL DALADRAPLL RADAVESGLV
DRIGFRDEAF ARIAELVGVE EVSGDEDDGP PRLYLSRYAG AARPRFAPPM PSIPRRGSKP
TIAVVTLEGA IVNGRGGRQV LPFGSSNAGA DTIAAALREV AADDAVSAIV LRVDSPGGSV
TASETIWREV KRARERGKPV VASMGAVAAS GGYYVSMDAD AIVANPGTIT GSIGVMSGKL
VVRDLKTRLG VGSDTVRTNA NADVWSVDEL FTPEQQADRE AEADLFYTDF VERVAAGRNM
SAEAVDAVAR GRIWTGADAL ERGLVDELGG FRTAVRRAKV LAGLDADAEV RLVSYPGSSW
LDLVRPRASS QPAAASLPDA VGSVLGRAVA GILEHVEQSL GGASVLWLGQ SRF
//
