ID A0A1X1TAJ3_9MYCO Unreviewed; 790 AA.
AC A0A1X1TAJ3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Glycosyl hydrolase {ECO:0000313|EMBL:BBZ37675.1, ECO:0000313|EMBL:ORV41580.1};
GN ORFNames=AWC00_15395 {ECO:0000313|EMBL:ORV41580.1}, MCNS_07380
GN {ECO:0000313|EMBL:BBZ37675.1};
OS Mycobacterium conspicuum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=44010 {ECO:0000313|EMBL:BBZ37675.1, ECO:0000313|Proteomes:UP000467385};
RN [1] {ECO:0000313|EMBL:ORV41580.1, ECO:0000313|Proteomes:UP000193407}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44136 {ECO:0000313|EMBL:ORV41580.1,
RC ECO:0000313|Proteomes:UP000193407};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBZ37675.1, ECO:0000313|Proteomes:UP000467385}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 14738 {ECO:0000313|EMBL:BBZ37675.1,
RC ECO:0000313|Proteomes:UP000467385};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBZ37675.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 14738 {ECO:0000313|EMBL:BBZ37675.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family.
CC {ECO:0000256|ARBA:ARBA00006768}.
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DR EMBL; AP022613; BBZ37675.1; -; Genomic_DNA.
DR EMBL; LQOR01000031; ORV41580.1; -; Genomic_DNA.
DR STRING; 44010.AWC00_15395; -.
DR OrthoDB; 9816160at2; -.
DR Proteomes; UP000193407; Unassembled WGS sequence.
DR Proteomes; UP000467385; Chromosome.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR Gene3D; 2.60.420.10; Maltose phosphorylase, domain 3; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF13; GLYCOSYL TRANSFERASE-RELATED; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000313|EMBL:BBZ37675.1}.
FT DOMAIN 16..270
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 327..678
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 687..750
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT REGION 761..790
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..777
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 488
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-50"
FT BINDING 361..362
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
FT BINDING 590..591
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR036289-51"
SQ SEQUENCE 790 AA; 87349 MW; 9201102703F104E4 CRC64;
MITQDAFPVE PWQVRETRLD LNLIAQSESL FALANGHIGL RGNLDEGEPH GLPGTYLNSF
YEIRPLPYAE AGYGYPEAGQ TVVDVTNGKI IRLLVGDEPF DVRYGKLLSH ERVLDMRAGT
LTRNAHWSSP SGKQVKVTST RLVSLAQRSV AAIEYCVEAV DEFVRVTVQS ELVTNEDQPA
TSADPRVAAI LDNPLEAVDH ENTETGALLM HRTRASALMM AAAMDHEIDV PGRVEFSTDA
RADLARTTVI CGLRPGQKLR IVKYIAYGWS SLRSRPALRD QAAAALHSAR YSGWQGLLDA
QRKYLDDFWE NADVEVEGDA ESQQAVRFGL FHLVQASARS EGRAIPSKGL TGTGYDGHAF
WDTEGFVLPV LTYTLPHAVA DALRWRASTL DLAKERAAEL GLDGAAFPWR TIRGQECSAY
WPAGTAAWHI NADIAMAFER YRIVTGDQSL EKDCGLRVLV ETARLWMSLG HHDRHGVWHL
DGVTGPDEYT AIVRDNVFTN LMAAHNLVTA ADACVRDPDA GAALGVTTEE MACWRDAANA
VHIPYDEGLG VHQQCEGFTT FAEWDFETNA TYPLLMHEAY VRLYPAQVIK QADLVLAMQW
QSHAFTAEQR ARNVDYYERR TVRDSSLSAC TQAVMCADVG HMELAHDYAY EAALIDLRDL
HSNTRDGLHM ASLAGAWMAL VAGFGGLRDD DGILDINPHL PDGISCLRFR LRWREFRLTV
DANHSDVTYT LRDGPGTELT IRHAGEELTL CTDAPTTIAV QPRKPLLPPP PQPPGREPMH
RRALSGTPTI
//
