ID A0A1X1TF39_9MYCO Unreviewed; 496 AA.
AC A0A1X1TF39;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Serine protease {ECO:0000313|EMBL:ORV43172.1};
DE SubName: Full=Trypsin {ECO:0000313|EMBL:BBZ08642.1};
GN ORFNames=AWC01_06630 {ECO:0000313|EMBL:ORV43172.1}, MDOR_28110
GN {ECO:0000313|EMBL:BBZ08642.1};
OS Mycolicibacterium doricum.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycolicibacterium.
OX NCBI_TaxID=126673 {ECO:0000313|EMBL:ORV43172.1, ECO:0000313|Proteomes:UP000193564};
RN [1] {ECO:0000313|EMBL:ORV43172.1, ECO:0000313|Proteomes:UP000193564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44339 {ECO:0000313|EMBL:ORV43172.1,
RC ECO:0000313|Proteomes:UP000193564};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBZ08642.1, ECO:0000313|Proteomes:UP000467201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 12405 {ECO:0000313|EMBL:BBZ08642.1,
RC ECO:0000313|Proteomes:UP000467201};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBZ08642.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 12405 {ECO:0000313|EMBL:BBZ08642.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
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DR EMBL; AP022605; BBZ08642.1; -; Genomic_DNA.
DR EMBL; LQOS01000019; ORV43172.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1TF39; -.
DR STRING; 126673.AWC01_06630; -.
DR KEGG; mdr:MDOR_28110; -.
DR OrthoDB; 9758917at2; -.
DR Proteomes; UP000193564; Unassembled WGS sequence.
DR Proteomes; UP000467201; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:ORV43172.1};
KW Membrane {ECO:0000256|SAM:Phobius}; Protease {ECO:0000313|EMBL:ORV43172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000193564};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 144..164
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 406..480
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
FT REGION 1..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 83..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 496 AA; 51017 MW; B98745AB7A98B956 CRC64;
MTNQDQASRR MAPRPVERPP VDPAAQRAFA RPSGVSGSFL GVDPHRHQAE YTPKDPAPDP
VLAEAFGRPP NASDSLQRHP ADAGALDAER SGDTADTEPD PWRDPNAPVA LGTPAVHAPA
PVQPPAHVGR LGVRDVLFGR KVSYVGLAIL LLTALMVGAL GGWVGNKTAE TVQAFTTSKV
TLETSDSGDP PEGRITKVAD AVADSVVTIE AKSGQEGSQG SGVVIDGRGY IVTNNHVISE
AATNPAAFEM TVVFNDGKEV PANLVGRDPK TDLAVLKVDN VDNLTVAKMG DSDTLQVGEE
VIAAGAPLGL RSTVTAGIIS ALNRPVPLSG DGSDTDTVID GVQTDASINH GNSGGPLIDM
DANVIGINTA GKSLSESASG LGFAIPVNEV KTVVEALIRD GRISHPTLGL TAKSVSNDVA
SGAQVANVMA GSAAERAGIL ENDVVVKVGT RDVADADEFV VAVRQLKIGE PAPIEVVRDG
RPVTLTVTPT PDASTD
//
