ID A0A1X1UWU7_9MYCO Unreviewed; 598 AA.
AC A0A1X1UWU7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Hydrogenase {ECO:0000313|EMBL:ORV61285.1};
GN ORFNames=AWC06_13065 {ECO:0000313|EMBL:ORV61285.1};
OS Mycobacterium fragae.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1260918 {ECO:0000313|EMBL:ORV61285.1, ECO:0000313|Proteomes:UP000194000};
RN [1] {ECO:0000313|EMBL:ORV61285.1, ECO:0000313|Proteomes:UP000194000}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 45731 {ECO:0000313|EMBL:ORV61285.1,
RC ECO:0000313|Proteomes:UP000194000};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
CC -!- COFACTOR:
CC Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC Evidence={ECO:0000256|PIRSR:PIRSR601501-1};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORV61285.1}.
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DR EMBL; LQOW01000016; ORV61285.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1UWU7; -.
DR STRING; 1260918.AWC06_13065; -.
DR OrthoDB; 9761717at2; -.
DR Proteomes; UP000194000; Unassembled WGS sequence.
DR GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR InterPro; IPR001501; Ni-dep_hyd_lsu.
DR InterPro; IPR029014; NiFe-Hase_large.
DR PANTHER; PTHR42958:SF4; HYDROGENASE EXPRESSION_FORMATION PROTEIN HUPK; 1.
DR PANTHER; PTHR42958; HYDROGENASE-2 LARGE CHAIN; 1.
DR Pfam; PF00374; NiFeSe_Hases; 2.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|PIRSR:PIRSR601501-1};
KW Magnesium {ECO:0000256|PIRSR:PIRSR601501-1};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR601501-1};
KW Nickel {ECO:0000256|PIRSR:PIRSR601501-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000194000}.
FT BINDING 78
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 81
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 81
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 571
FT /ligand="Ni(2+)"
FT /ligand_id="ChEBI:CHEBI:49786"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 574
FT /ligand="Fe cation"
FT /ligand_id="ChEBI:CHEBI:24875"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
FT BINDING 577
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR601501-1"
SQ SEQUENCE 598 AA; 67044 MW; A5788D7F7AD70547 CRC64;
MTITEPAQTG QTGSSQTIEM AWDPITRIVG NLGIYTKINF GTKTVEECHS TSSLFRGYSV
FMKGKDPRDA GFITSRICGI CGDNHTTCSI YCQNMAYGID NPPLAETIIN LGEAAEYIFD
HTIFQDNLVF VDFCEAIVKE TNPGVLAKAE QTEARNAQIH GYRTIADIMR AFNPFEGEIY
REALRVSRTT REMFCIMEGR HVHPSTLYPG GVGTMPSPTT FTDYLTRLMG VLDFVKKAVA
LNDDVFDFFY DALPGYEEVG RRRVLLGCWG AWQDAFTVDY KYEHMTDWGR AMFVTPGVVV
DGKLVTTDLV DINLGIRILL GSSYYHDWVN EEPFVTHDPL GNPVDIRHPW NQTTLPEPQK
RDFNDKYSWV MSPRWFDKNS GEHLALDTGG GAFARLYATA LAGLVDTPYV KSTGHSVQIS
LPKSRTLPET TLEWQIPQWS NALERDRARV YFVAYASAMA FFFAERAMEM VRSGETKVFN
NFEVPHEKSI GCGFHEAVRG VLSHHMVIDK GKIANYHPYP PTPWNGSPRD SFGTPGPYED
AVKDTPIFED NGPDNFRGVD IMRAVRSFDP CLPCGVHMYV GGGRTIKKTH SPTGYLGS
//
