ID A0A1X1XNQ0_9MYCO Unreviewed; 754 AA.
AC A0A1X1XNQ0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=ESX-1 secretion system protein EccCa1 {ECO:0000313|EMBL:BBX99065.1};
DE SubName: Full=Peptidase S49 {ECO:0000313|EMBL:ORW00483.1};
GN Name=eccCa1 {ECO:0000313|EMBL:BBX99065.1};
GN ORFNames=AWC15_08365 {ECO:0000313|EMBL:ORW00483.1}, MLAC_43590
GN {ECO:0000313|EMBL:BBX99065.1};
OS Mycobacterium lacus.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=169765 {ECO:0000313|EMBL:BBX99065.1, ECO:0000313|Proteomes:UP000466396};
RN [1] {ECO:0000313|EMBL:ORW00483.1, ECO:0000313|Proteomes:UP000193202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44577 {ECO:0000313|EMBL:ORW00483.1,
RC ECO:0000313|Proteomes:UP000193202};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBX99065.1, ECO:0000313|Proteomes:UP000466396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15657 {ECO:0000313|EMBL:BBX99065.1,
RC ECO:0000313|Proteomes:UP000466396};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBX99065.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 15657 {ECO:0000313|EMBL:BBX99065.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; AP022581; BBX99065.1; -; Genomic_DNA.
DR EMBL; LQPF01000173; ORW00483.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1XNQ0; -.
DR STRING; 169765.AWC15_08365; -.
DR KEGG; mlj:MLAC_43590; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000193202; Unassembled WGS sequence.
DR Proteomes; UP000466396; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR023836; EccCa-like_Actinobacteria.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03924; T7SS_EccC_a; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR PANTHER; PTHR22683:SF1; TYPE VII SECRETION SYSTEM PROTEIN ESSC; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000466396};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 41..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 456..665
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT BINDING 479..486
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 754 AA; 81436 MW; D79D9E15E166437E CRC64;
MTTKKFTPTI TRGPRLTPGE ISLTPPDDLG IDIPPSGVQK ILPYVMGGAM LGMIAIMIAG
GTRQLSPYML MMPLMMVVMM VGSLAGGTGG GGKKVPEINA DRKEYLRYLA GLRSRVTTSA
SSQVAFFSYH APHPEDLLSI VGTQRQWSRP ANSDFYAATR IGIGDQPAVD RLLKPAVGGE
LAAASAAPQP YLEPVSHMWV VKFLRTHGLI HDCPKLVQLR TFPTIAIGGD RAGACGLLTA
MICHLAVFHP PDLLQIRVLT EDPDDPDWSW LKWLPHVQHQ TETDAAGPTR MIFTRPDSLA
DLAARGPHAP DTLPTGPYVV VVDLTGGKAG FPPDGRAGVT VITLGNHRGS AYRIRVDENG
TADDRLPGQS FRLVTSVADN MSPHEANRLA RKLAGWSITG TILDKTQRVQ KKVATEWHQL
VGAKSVEEIT PSRWRMYTDT DRDRLKIPFG HELKTGNVMY LDIKEGAEFG AGPHGMLIGT
TGSGKSEFLR TLILSLVAMT HPDQVNLLLT DFKGGSTFLG MEKLPHTAAV VTNMAEEAEL
VSRMGEVLTG ELDRRQSILR QAGMQVGAAG ALSGVAEYEK YRERGADLPP LPTLFVVVDE
FAELLQSHPD FIGLFDRICR VGRSLRVHLL LATQSLQTGG VRIDKLEPNL TYRIALRTTS
SHESKAVIGT PEAQYITNKE SGVGFLRVGM EDPVKFSTFY ISGPYVPPTA GETNGDGTAA
GPQMVKQSVR IRKFTAAPVM EVGAPPASGG ALTS
//
