UniProt: A0A1X1Y2H6

Database: UniProt
Entry: A0A1X1Y2H6_9MYCO

LinkDB:  A0A1X1Y2H6_9MYCO 
Original site:  A0A1X1Y2H6_9MYCO

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Ontology (3)   
   GO (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1)   
   KEGG GENES (1)   
DNA sequence (2)   
   EMBL (2)   
Protein domain (6)   
   InterPro (4)   
   Pfam (2)   
Literature (1)   
   PubMed (1)   
All databases (14)   

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ID   A0A1X1Y2H6_9MYCO        Unreviewed;       469 AA.
AC   A0A1X1Y2H6;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Diacylglycerol O-acyltransferase {ECO:0000256|ARBA:ARBA00013244, ECO:0000256|RuleBase:RU361241};
DE            EC=2.3.1.20 {ECO:0000256|ARBA:ARBA00013244, ECO:0000256|RuleBase:RU361241};
GN   Name=tgs3 {ECO:0000313|EMBL:BBX95181.1};
GN   ORFNames=AWC15_02095 {ECO:0000313|EMBL:ORW05307.1}, MLAC_04750
GN   {ECO:0000313|EMBL:BBX95181.1};
OS   Mycobacterium lacus.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=169765 {ECO:0000313|EMBL:BBX95181.1, ECO:0000313|Proteomes:UP000466396};
RN   [1] {ECO:0000313|EMBL:ORW05307.1, ECO:0000313|Proteomes:UP000193202}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44577 {ECO:0000313|EMBL:ORW05307.1,
RC   ECO:0000313|Proteomes:UP000193202};
RA   Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA   Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA   Olivier J., Enrico T., Nicola S.;
RT   "The new phylogeny of the genus Mycobacterium.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BBX95181.1, ECO:0000313|Proteomes:UP000466396}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 15657 {ECO:0000313|EMBL:BBX95181.1,
RC   ECO:0000313|Proteomes:UP000466396};
RX   PubMed=31287781;
RA   Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA   Iida T., Fujita J., Nakamura S.;
RT   "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT   species based on 7547 genomic profiles.";
RL   Emerg. Microbes Infect. 8:1043-1053(2019).
RN   [3] {ECO:0000313|EMBL:BBX95181.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JCM 15657 {ECO:0000313|EMBL:BBX95181.1};
RA   Matsumoto Y., Motooka D., Nakamura S.;
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol
CC         + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20;
CC         Evidence={ECO:0000256|ARBA:ARBA00001039,
CC         ECO:0000256|RuleBase:RU361241};
CC   -!- PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004771, ECO:0000256|RuleBase:RU361241}.
CC   -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC   -!- SIMILARITY: Belongs to the long-chain O-acyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00009587, ECO:0000256|RuleBase:RU361241}.
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DR   EMBL; AP022581; BBX95181.1; -; Genomic_DNA.
DR   EMBL; LQPF01000113; ORW05307.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X1Y2H6; -.
DR   STRING; 169765.AWC15_02095; -.
DR   KEGG; mlj:MLAC_04750; -.
DR   OrthoDB; 9810950at2; -.
DR   UniPathway; UPA00282; -.
DR   Proteomes; UP000193202; Unassembled WGS sequence.
DR   Proteomes; UP000466396; Chromosome.
DR   GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0019432; P:triglyceride biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR014292; Acyl_transf_WS/DGAT.
DR   InterPro; IPR045034; O-acyltransferase_WSD1-like.
DR   InterPro; IPR009721; O-acyltransferase_WSD1_C.
DR   InterPro; IPR004255; O-acyltransferase_WSD1_N.
DR   NCBIfam; TIGR02946; acyl_WS_DGAT; 1.
DR   PANTHER; PTHR31650:SF1; DIACYGLYCEROL O-ACYLTRANSFERASE TGS4-RELATED; 1.
DR   PANTHER; PTHR31650; O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN; 1.
DR   Pfam; PF06974; WS_DGAT_C; 1.
DR   Pfam; PF03007; WS_DGAT_cat; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU361241};
KW   Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798,
KW   ECO:0000256|RuleBase:RU361241};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW   ECO:0000256|RuleBase:RU361241};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW   ECO:0000256|RuleBase:RU361241};
KW   Reference proteome {ECO:0000313|Proteomes:UP000466396};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361241}.
FT   DOMAIN          5..271
FT                   /note="O-acyltransferase WSD1-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03007"
FT   DOMAIN          322..464
FT                   /note="O-acyltransferase WSD1 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06974"
SQ   SEQUENCE   469 AA;  50829 MW;  B6DF04A561DA377A CRC64;
     MVTRLSTVDA SFYRLENTAT PMYVGSLFIL ARPRAGFSYE TLLATIEQRL PQIPRYRQKV
     REVNVAMARP VWIDDPDFDI TYHVRRSALP SPGSDEQLHE LIARLAARPL DKSRPLWEMY
     LVEGLDKNRV ALYTKSHQAL INGVTALAIG HVIVDRTRRP PPFPEDIWIP ERDPGNIRLL
     LGAIGDWVVG PGAQMQAVGS AIAGLVTNSG QVVDTARRFV DIARTLARGT APSSPLNATV
     SRNRRFTVAQ GRLEDYRTVR ARYDCDVNDV VLAVIAGALS SWLMSRGEAL APTATIRAMA
     PLSVYADDQL DSTGPGQAIS QVTPFLVDLP VGEGNAVVRL SQIAHATESN PTAASLVDAR
     TIVTLSGFAP PTLHAMGIRV ATSFSARLFN LLVTNAPGAQ AQMYVAGTKL LAAYAVPPLL
     HNQALAISVT SYNGMLYFGI NADRAAMSDV DLLPGLLSQS LDELLEASR
//

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