ID A0A1X1Y6M1_9MYCO Unreviewed; 1029 AA.
AC A0A1X1Y6M1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:BBX96272.1};
GN Name=pks9 {ECO:0000313|EMBL:BBX96272.1};
GN ORFNames=AWC15_21030 {ECO:0000313|EMBL:ORW06773.1}, MLAC_15660
GN {ECO:0000313|EMBL:BBX96272.1};
OS Mycobacterium lacus.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=169765 {ECO:0000313|EMBL:BBX96272.1, ECO:0000313|Proteomes:UP000466396};
RN [1] {ECO:0000313|EMBL:ORW06773.1, ECO:0000313|Proteomes:UP000193202}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44577 {ECO:0000313|EMBL:ORW06773.1,
RC ECO:0000313|Proteomes:UP000193202};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:BBX96272.1, ECO:0000313|Proteomes:UP000466396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 15657 {ECO:0000313|EMBL:BBX96272.1,
RC ECO:0000313|Proteomes:UP000466396};
RX PubMed=31287781;
RA Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA Iida T., Fujita J., Nakamura S.;
RT "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT species based on 7547 genomic profiles.";
RL Emerg. Microbes Infect. 8:1043-1053(2019).
RN [3] {ECO:0000313|EMBL:BBX96272.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=JCM 15657 {ECO:0000313|EMBL:BBX96272.1};
RA Matsumoto Y., Motooka D., Nakamura S.;
RL Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
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DR EMBL; AP022581; BBX96272.1; -; Genomic_DNA.
DR EMBL; LQPF01000084; ORW06773.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1Y6M1; -.
DR STRING; 169765.AWC15_21030; -.
DR KEGG; mlj:MLAC_15660; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000193202; Unassembled WGS sequence.
DR Proteomes; UP000466396; Chromosome.
DR GO; GO:0016746; F:acyltransferase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000466396};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 3..394
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 873..951
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1029 AA; 108002 MW; A0CC39578555837C CRC64;
MQPTDIAVIG LACRFPAAVN PREFWQLVRD GREVTGSIDD VADFDASFFN LSPREASAMD
PRQRLALELT WELLEDAHVV PAAVRGERVA VYLGAMNDDY AFLTLDGNDI DHHSFAGVSR
GMIANRLSYA FGMHGPSVTV DSGQSSSLVA VHLACESLRT GESPMAIAGG VHLNLAAETT
TLEAEFGALS SSGHTCAFDR RADGYVRGEG GGLVLLKPLR AALDDGDRIR AIIRGSAVGN
AGDAAAGLTV PSAAGEADVI RRALSNAGLD IGQIDFVEAH GTGTEVGDPV EASALGEVFV
QRHDRPLMVG SVKTNIGHAG AASGIAGLLK AVLAIENASI PPSLNYSSPV IDLERLGLRV
NTALTPWPMG DNPRRAGVSS FGMGGTNAHV ILEQAPTLLA AAEIGAADHD NAVVPWVLSG
RSAEALADQA RRLLAHIATD NRLRVADVGW SLASTRSAFE HRAVLVGADR ESLTTGLAAL
AAGEQGAVVG RVRSQGKTVF AFPGQGSQWL GMGRQLHERF PPFAEAFDEV VAALDRYLRL
PLRQVMWGAD GKLLESTEFA QPALLAVELA LAALLQSCAV VPDFVMGHSV GEISAACLAG
VLSVADAAKV VAARGQLMAA LPAGGVMVAV AAGEDEVTPL LIDGVSIAAI NGPNAVVISG
SAPAVMAVAD RLAQRGRRVH RLAVSHAFHS TLMEPMVEQF RDALAELVPA EPRIGLVSNM
TGQLAGPGYG SAQYWADHVR QPVRFADGVR AVEALGAGVF IEVGPGGAVM AAVADSLSEK
SAGEADPTVV AMAKDRPEVA SAVTALGRLF TAGVGVDWGP VFNGVAARRV ELPTYAFQRR
RYWLGGAGDA PVERPMPNVA ERLRGLPPTE RHRQLVELVR THAAVVLGHP SPVDIDAGRA
FQDLGFDSMA GVELRNRLKA VMGPAGLVLP RTLIFDHPTP TALAHYLGQQ LSGSRHDELA
EEKIRSLLMR IPIHELRRTG LLDKLLLLAG ASEKPLLEGA VSDDVIDSLS PQALIAMALR
PADDDDVIE
//
