ID A0A1X1ZA22_9MYCO Unreviewed; 1449 AA.
AC A0A1X1ZA22;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ORW20051.1};
GN ORFNames=AWC19_15810 {ECO:0000313|EMBL:ORW20051.1};
OS Mycobacterium palustre.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=153971 {ECO:0000313|EMBL:ORW20051.1, ECO:0000313|Proteomes:UP000193529};
RN [1] {ECO:0000313|EMBL:ORW20051.1, ECO:0000313|Proteomes:UP000193529}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44572 {ECO:0000313|EMBL:ORW20051.1,
RC ECO:0000313|Proteomes:UP000193529};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORW20051.1}.
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DR EMBL; LQPJ01000127; ORW20051.1; -; Genomic_DNA.
DR STRING; 153971.AWC19_15810; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000193529; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.980; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 945..1022
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1449 AA; 154790 MW; AC53D396CCEA49C3 CRC64;
MALSPLQQGL FSMAALASEA GAAETAGPDE VDPYVIAMSA DVVGPLDVPL LRGCAAAMLT
RHPNLRASFV HGNLSRPVQV IPSTVEVPWR HVRGAPDEVG RLEAEERQRR FDMARGPLLR
FLLVEMPDEQ WRLAIVAHHI VIDGWSLPLF VSELLALYRA GGDTAVLPPA PRPYRDYIGW
LAARDQDASR AVWAQHLKGL DGPTLLSPAL AATSPPAGIP RRTTVRLDAE ATAALAGAAR
ARGVTLNTLV QFAWAAVLSA FTDRSDVAFG VTVSGRPGDL SGVEAMVGMF INTVPLRVRL
NPRETVGTQC LGLQRDSAAL REHSYLGHAE LRGLAGVGEM FDTLLVYENF PPGGVVGATE
FVANGATFRP VALESVSHFP VTIAAHLSAG ELTVLVEVLD GALGDMAPEA LGGRLLAVTQ
RLAPAWERPL RDVDILLDGE RGSTGSPASI GRPVAVHTRF AEIAAAQPDS IAVSWAGGRL
TYRELDALAD RLAAALRRAG AGSETPVAVR LSRGPSYVAT MLAILKAGAM IVPLDPAMPG
ERVDDILRQT SAPIVIDEPA YAALTGSGAA PADQRPATVP PDQAAYAVFT SGTTGAPKGV
IGTHRALSAY ADDHIDRVLK PAAARVGRPL RVAHAWSFTF DAAWQPLAAL LDGHCVHIVD
DERQRDAEAL VDTIDRFGLD MIDTTPSMFA QLHSAGLLRR VPLAVLALGG EALGSTAWQA
IQAECARTAM TAFNCYGPTE TTVEAVVAAI DEHPRPTIGR PTRSTRAYVL DSWLRPVPDG
AAGELYLAGD QLTRGYLGRA AETAARFVAD PTGRGRRMYR TGDLVRRMPD GGLEFLGRSD
DQLKIRGFRV EPGEIAAALT GHDGVRGAYV TARPHTSGPR LTAYVAGGAN PPSAAALRSM
LAERLPRYLV PHHIVVLDEL PLTPHGKIDE RALAAIDLTE GATTPPETPT EAALAEAFAD
VLGAQDIEKI DVAADFHQMG LDSIVALSVV QAARRRGIAL RARLMLECDT IRELAVAVAA
DTARHAPSEA TAQAGEPIPV LPNARWLYEH GNPRRLAQTE VIRLPDTVTR EGLRALLGAV
IDGHEVLRCR LDRDAMTLVA QPKTNVLTEA QVGGELVVEV AAHTRRAVEG LDPGAGRLLS
AMWLREPDGP GVLVLTAHVL AMDPASWRIV LSELDAGLHA LSAGRQPAPA REHTSYRRWS
RALAERAKTL TTQAFWVGEL QGADPPLGAR RLRPETDRVG DVAVSVSTCG ADLTARLMAL
GRPMNELLVT AAARTVTAWR RRRGQETPAP LLALETHGRA DAHIDATIDT SDTVGLLSAI
YPLRIHCDGL TDLARIPGSP VDYGLLRYLR SDTDLRDHPE PQLLLNFLGS AHADVGGLRL
ERELLADVDP VPEPEQAVRH ELTVVAGILG AGDARMLATQ WRALPDILDP ADVAALQELW
NDALWEMVR
//
