ID A0A1X1ZNE2_9MYCO Unreviewed; 553 AA.
AC A0A1X1ZNE2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=AWC19_08475 {ECO:0000313|EMBL:ORW24867.1};
OS Mycobacterium palustre.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium simiae complex.
OX NCBI_TaxID=153971 {ECO:0000313|EMBL:ORW24867.1, ECO:0000313|Proteomes:UP000193529};
RN [1] {ECO:0000313|EMBL:ORW24867.1, ECO:0000313|Proteomes:UP000193529}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44572 {ECO:0000313|EMBL:ORW24867.1,
RC ECO:0000313|Proteomes:UP000193529};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORW24867.1}.
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DR EMBL; LQPJ01000100; ORW24867.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X1ZNE2; -.
DR STRING; 153971.AWC19_08475; -.
DR Proteomes; UP000193529; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR033463; sCache_3.
DR InterPro; IPR029151; Sensor-like_sf.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR016120; Sig_transdc_His_kin_SpoOB.
DR InterPro; IPR039506; SPOB_a.
DR PANTHER; PTHR43065:SF10; PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3; 1.
DR PANTHER; PTHR43065; SENSOR HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF17203; sCache_3_2; 1.
DR Pfam; PF14689; SPOB_a; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR SUPFAM; SSF55890; Sporulation response regulatory protein Spo0B; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ORW24867.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 431..543
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 553 AA; 58683 MW; E93BB13EF12A15E3 CRC64;
MRLATQVMLL QLVIVTLTLL VALVLFAWFN RHRLDLQYNR HALDIARVVS SSPTVINNIG
RYDTEKLSPG PALIGELTTG PIQGIASRVE DRTHASFVVV ANMRGIKLAA PDRDTLGLSV
RADITRALTG HEGTFHEATP LGRAIVAQVP VLEPGSGRVL GAVLVGISTK EFDDQFSRNL
RVMAGIAGVL LLLGGAGSVV LARRWRGLTL GLRPDEITEL VRTQAAVLQG IGEGVLATDT
AGRTTFVNDE ACRLLEIGTD TGRPVDEIGL TPRVLDVFKA ADSKPSLATV GERIVVVSAR
PVSREGRELG TVLVVRDRTD VESLTRQLDA VQVMSTVLRA QRHEFANRLH LLTGLLHGGH
VEEGLQYLEE LLGAGPLGSA LPGIDAIRDT YLQAFLAAKG AAAREAGVTL TIGENTWVPG
RLVLPVDVTT VLGNLLDNAI DAVRMSGNAV KEVEVELLQE GTTLHITVAD SGDGVAPGFV
DQLFTEGTTT KPDSGIPGGR GIGLALSRQI TRALGGDLLL ASAGNAELRL CGAEFIARLP
GVMVEEAQWA TQT
//
