ID A0A1X2A0P0_9MYCO Unreviewed; 590 AA.
AC A0A1X2A0P0;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Signal peptide peptidase SppA {ECO:0000313|EMBL:ORW34506.1};
GN ORFNames=AWC17_23880 {ECO:0000313|EMBL:ORW34506.1};
OS Mycobacterium nebraskense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=244292 {ECO:0000313|EMBL:ORW34506.1, ECO:0000313|Proteomes:UP000193781};
RN [1] {ECO:0000313|EMBL:ORW34506.1, ECO:0000313|Proteomes:UP000193781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44803 {ECO:0000313|EMBL:ORW34506.1,
RC ECO:0000313|Proteomes:UP000193781};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S49 family.
CC {ECO:0000256|ARBA:ARBA00008683}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORW34506.1}.
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DR EMBL; LQPH01000019; ORW34506.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2A0P0; -.
DR STRING; 244292.ABW17_10480; -.
DR Proteomes; UP000193781; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:InterPro.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006465; P:signal peptide processing; IEA:InterPro.
DR CDD; cd07018; S49_SppA_67K_type; 1.
DR CDD; cd07023; S49_Sppa_N_C; 1.
DR InterPro; IPR001907; ClpP.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR004634; Pept_S49_pIV.
DR InterPro; IPR004635; Pept_S49_SppA.
DR InterPro; IPR002142; Peptidase_S49.
DR InterPro; IPR047217; S49_SppA_67K_type_N.
DR InterPro; IPR047272; S49_SppA_C.
DR NCBIfam; TIGR00705; SppA_67K; 1.
DR NCBIfam; TIGR00706; SppA_dom; 1.
DR PANTHER; PTHR33209; PROTEASE 4; 1.
DR PANTHER; PTHR33209:SF1; SERINE PROTEASE SPPA, CHLOROPLASTIC; 1.
DR Pfam; PF01343; Peptidase_S49; 2.
DR PIRSF; PIRSF001217; Protease_4_SppA; 1.
DR PRINTS; PR00127; CLPPROTEASEP.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825}.
FT DOMAIN 106..259
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT DOMAIN 370..521
FT /note="Peptidase S49"
FT /evidence="ECO:0000259|Pfam:PF01343"
FT ACT_SITE 174
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
FT ACT_SITE 387
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR001217-1"
SQ SEQUENCE 590 AA; 62240 MW; 5E224B58773CB1DA CRC64;
MFAFLPSIPG VDDVRALADR VDTARHHGVP NGCVLELDLR TAPPEATGFD PLAIFTGGRP
MALRDAVAAL HRAAEDPRVA GLIARVQLAA SPPAAVQELR EAIAAFSAAK PSLAWAETYP
GTLSYYLASA FREVWMQPSG SVGLIGFASN ATFLRDAFDK AGIEPQFVAR GQYKSAANRF
TEHGFTTAHR EAVTRMLESL QEQAWQAIAE SRKLDPGALD ALADRAPLLR DDAVAAGLLD
RIGFRDEAYS RIAELVGVKD VSDDTAPRRL YLARYAGAAR SRLAPPKPSV PGRRPKPTLA
VITLDGMIVD GRGGPQFLPF GAATAGGDTI GAALREAGAD DSVSAIVLRV NSPGGTITAS
ESIWREVTRA RNRGKTVVAS MGAVAASGGY YVSMGADAIV ANPATVTGSI GVITGKLVIR
DLLERLGVGS DTVRTNANAD AWSIDAPFTP EQQAHREAEA DLFYADFVQR VAEARNLTAE
AVDRVAQGRI WTGADACKHG LVDELGGFRT AVRRAKVLAG LDADSDVRIV SYPSSSLLDL
VRPRASSQPA AASLPDALAA LLGRTVSGIV DNIEQSMSGA SVLWPGQSRF
//
