ID A0A1X2A290_9MYCO Unreviewed; 2186 AA.
AC A0A1X2A290;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ORW35150.1};
GN ORFNames=AWC17_22415 {ECO:0000313|EMBL:ORW35150.1};
OS Mycobacterium nebraskense.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=244292 {ECO:0000313|EMBL:ORW35150.1, ECO:0000313|Proteomes:UP000193781};
RN [1] {ECO:0000313|EMBL:ORW35150.1, ECO:0000313|Proteomes:UP000193781}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 44803 {ECO:0000313|EMBL:ORW35150.1,
RC ECO:0000313|Proteomes:UP000193781};
RA Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA Olivier J., Enrico T., Nicola S.;
RT "The new phylogeny of the genus Mycobacterium.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORW35150.1}.
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DR EMBL; LQPH01000008; ORW35150.1; -; Genomic_DNA.
DR STRING; 244292.ABW17_07780; -.
DR OrthoDB; 2472181at2; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000193781; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd19540; LCL_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 2.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 2.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 2.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 2.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 2.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 2.
DR PROSITE; PS50075; CARRIER; 2.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}.
FT DOMAIN 987..1062
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2069..2143
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1541..1561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2048..2073
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1541..1559
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2186 AA; 237759 MW; 6609D469D661A036 CRC64;
MTEITGTSAR LDDERLELLR RKIAERGLAR TAENEAPVAT HEEPRMSVGQ HRMWFVQSVD
PDSALLNVCV SYRVTGTVDI DRLRHAVDAV AARHPVLHTT YDTGADGDPY PFIREGLRPE
WAEHDLSGLT DQARRLRLDV LAQRDFRRPF DLAKDSPLRV TVARLSADEL MLLITAHHVA
WDDASWTPFF ADLTRAYTDP DGFGRVPAVA AAPPDDAADP AADAEYWRPL MANLPEPLEL
PGPNGSVVPS TWRAQRATTR LSAGTVDRAA TLARETGATP YMVLMAAFAA LVHRYTQSTD
FLIAAPVLNR GIGTESAIGY YGNTVVIRLR PEPHQTFREL LAQTRDGAVG AFAHSRADLD
WLVREANPDR RHGADRMTRV SFGQREPDGA GFCPPGVRCE RGELRGHFNQ LPLSFMIELD
RKADGSSGGL AEAEYLVEVL DQQLVDQLLR HYAVLLDNVL ANPDSALSAC GLMGADDAEW
LRWASTGAEF ETPPATLPAL VTRRAALSPD AVAVVYESRE YSYREIDEES NRLAHWLIEQ
GIGTEDRVAV LLDKSPELVI TALGVLKAGA VYLPVDPTYP ADRLTFILGD ADAKLVLREP
VTGLSRYPAT APTELVRPLA PHNTAYLIYT SGSTGLPKGV PVPHAPIAEY FVWFGEEYRV
DETDRLLQVA SPSFDVSMGE IFGTLIMGAR LVIPRPDGLR DIGYLTELLS REGITSMHFV
PSLLGLFLSL PGVSQWRTLR RVPIGGEALP GEIADKFHAT FDALLYNFYG PTETVVNCTS
YPVEGAQGTR VVPIGRPKIN TQVHLLDNAL RPVPVGAIGE IYIGGTHVAH GYHRRPGLTA
ERFVADPFTP GGRLYRSGDL ARRNADGDIE FVGRADEQVK IRGFRIELGE VAAAISVDPS
VGQAVVLAMD LPRLGKSLVG YVTPVQGGSP ETVEVERIRA RVAAALPDYM TPAAYVALDE
IPITAHGKID RAALPQPQIA AAGEYRDPAT PTERRIAALF SALLGHDRVG VDDSFFDLGG
HSLVATKLVT AIRSECGVEL GIRDVFELAT VSLLAERVDQ LSVGELRQSR PKLIATAHDE
PMPLSASQLR SWFAYRVDGP SWVNNIPFAA KLTGPWDIEA LIVAVGDVVA RHEILRTSYV
ELDGVPYQMV GPAGEVSVSR ATGPDEGWLQ RQLDAERRHR FELDRELPVR VALLHTADNV
AEHVLSLVVH HIASDHWSAG VLFADVMTAY RARRAGEAPA WAPLRVQYAD YAAWQGEFLG
DASGQESPVA AAQREYWNRQ LAGLPEDTGL RPDFPRQPVP SGEGESVEFR IDAATRAKLA
ELSRELGITE FMLLQTAVAV VLHKAGGGLD IPLGTPVAGR TDAELDQLIG FFVNILVLRN
DLTGNPTLRE LLTRARETAL TAYAHQDLPF DRVVDSVSPV RSLSRNPLFQ VVVHVRDHLP
ATRVIEQAPE GDGQDTVCTS LEPVFDMAHA DLSVNFFGTD GSGDIGYDCN LIFRTELYTR
ATIERLAGWL TRVVTEFADD VDQTLRDVQL TDAEERRRML EHWSRGQRRP HDRPRTIPEL
LEPSRSWGPD RIAVRCRDEQ IDYPALHRRS DNLAALLAGR GVGPGSLVGL STRRSIDLVV
ALVAIMKAGG GYFPIDPGYP LARKQFMLDD VQPPVVVATA EAADSMPEVP EVTVISLDDP
QVRAAVENAE VGRRELPLPH PDDPMYLVFT SGSTGKPKGA LGTHRSMAAR LDWQLRHYPP
RTDDVRLAQA SITFLEGGME MLAGLAAGAT MILADDAEHR DPEALGELMN RYAVAQVTAV
PSLVSALVDS RPDAVRALSR LVCGGEPVSS ALLQRLVSVC AGADTELLNN IGSTETSGAV
SRGRLEPPNP LVGKPVPGAD AFLLDDGLRP VPVGVVGELY YAGDQLARGY WKRPGLTATR
FVANPFALEP GSRLYRSGDL ARWTDDGRLE FVGRSDHQVQ VRGFRVELAE VEAELAGVDG
VAAAAARTWE VRGGTSLAGY VVPHQPITDD AAKALFASEV RAAIGTTLPG YMMPSSLTVL
DALPKTESGK LNRPGLPRPA ISTSARTEPS RTDTERALAK VFAELLSTPE VGRFDDFFAL
GGDSILSVQL ASRARAAGLA VSPRMIFENP TVQQLAAALD ALGRDAAEQF EEPLDTRFEP
MSTSGLSAED LAAVTQLWSS SRDGTP
//
