ID   A0A1X2BLQ2_9MYCO        Unreviewed;      1079 AA.
AC   A0A1X2BLQ2;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   SubName: Full=Fatty acyl-AMP ligase {ECO:0000313|EMBL:ORW64109.1};
GN   ORFNames=AWC23_26000 {ECO:0000313|EMBL:ORW64109.1}, MSAS_13810
GN   {ECO:0000313|EMBL:BBX62207.1};
OS   Mycobacterium saskatchewanense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium simiae complex.
OX   NCBI_TaxID=220927 {ECO:0000313|EMBL:BBX62207.1, ECO:0000313|Proteomes:UP000467517};
RN   [1] {ECO:0000313|EMBL:ORW64109.1, ECO:0000313|Proteomes:UP000193387}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44616 {ECO:0000313|EMBL:ORW64109.1,
RC   ECO:0000313|Proteomes:UP000193387};
RA   Tarcisio F., Conor M., Antonella G., Elisabetta G., Giulia F.S., Sara T.,
RA   Anna F., Clotilde B., Roberto B., Veronica D.S., Fabio R., Monica P.,
RA   Olivier J., Enrico T., Nicola S.;
RT   "The new phylogeny of the genus Mycobacterium.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:BBX62207.1, ECO:0000313|Proteomes:UP000467517}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 13016 {ECO:0000313|EMBL:BBX62207.1,
RC   ECO:0000313|Proteomes:UP000467517};
RX   PubMed=31287781;
RA   Matsumoto Y., Kinjo T., Motooka D., Nabeya D., Jung N., Uechi K., Horii T.,
RA   Iida T., Fujita J., Nakamura S.;
RT   "Comprehensive subspecies identification of 175 nontuberculous mycobacteria
RT   species based on 7547 genomic profiles.";
RL   Emerg. Microbes Infect. 8:1043-1053(2019).
RN   [3] {ECO:0000313|EMBL:BBX62207.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JCM 13016 {ECO:0000313|EMBL:BBX62207.1};
RA   Matsumoto Y., Motooka D., Nakamura S.;
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AP022573; BBX62207.1; -; Genomic_DNA.
DR   EMBL; LQPR01000084; ORW64109.1; -; Genomic_DNA.
DR   STRING; 220927.AWC23_26000; -.
DR   KEGG; msak:MSAS_13810; -.
DR   OrthoDB; 2472181at2; -.
DR   Proteomes; UP000193387; Unassembled WGS sequence.
DR   Proteomes; UP000467517; Chromosome.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:InterPro.
DR   CDD; cd05931; FAAL; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR040097; FAAL/FAAC.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR010080; Thioester_reductase-like_dom.
DR   NCBIfam; TIGR01746; Thioester-redct; 1.
DR   PANTHER; PTHR22754:SF32; DISCO-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR22754; DISCO-INTERACTING PROTEIN 2 DIP2 -RELATED; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Ligase {ECO:0000313|EMBL:ORW64109.1}.
FT   DOMAIN          12..412
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          710..947
FT                   /note="Thioester reductase (TE)"
FT                   /evidence="ECO:0000259|Pfam:PF07993"
SQ   SEQUENCE   1079 AA;  118667 MW;  85447E303EE56C05 CRC64;
     METLIDYLRM WEERQPEQTL YRFVDAGGRE LERYTYQSFA ERTRELAAYL SAESRLRAGD
     RVLLLYPPGL EMVAALFACA RIGVIAVPVS PPLPMSFEAG LAKLSFIARD CQAKAVLSTK
     QLEHDFGVLL GDRQGALPWA DAERLPELPW VATDGAQDFG GAPVADTPGR VLFLQYTSGS
     TSDPKGVIVS HANVVANASA FTESEVAVSW LPQHHDMGLI SAYLFILVIG GTTHAMSPED
     FLKRPSAWLR LISDVRATHT PAPNFALEYC LREDKLPTAE LEGVDLSSLE SMVIGAEPLR
     ARTFTSFRRR FAPYGLRPDA VTGAYGLAEN TLVVSLRGRQ IIAVNKRALQ NDLARVEKAV
     PENNNQAALV SSGKPVAGNV VRIVDPDSRR ALGEGRVGEV WVAGASKGGG YWHRPEATAE
     AFAARIAGDE QHTYLRTGDL GFLYEGELFV CGRTKDLIIV RGVNTYPADI EAIAERSAAQ
     IRNGCVAAFS VERDQQETLV VIAEVRDPDA LPDGKALARA IRRHCQIDPD TIAFVPARTV
     PKTTSGKIRR AQTRQLWLDG ELPVLASYTH LTRRAPDTGA GPLERFRHLM ESYDLTGDED
     CSFADLGIDS LALAELRADL QALLEEHGAG EVAGDVNTRL LQRLTVAEFF GLVRQFGDEA
     GQPLDALRRA LDEISAENEA YESLQMSTDA RLPLPALPPA REGATTDILL TGATGFLGPF
     LISSLLERTS YTLHTLIRAT DAEHGVDRIV ASLRRAQVWS PALETQVRAR VRVVCGDLAE
     PNLGLDPAAF QQLAEDVHAV VHNGALVNYV RTYDALRPAN VGGTHQLLRL AMTGHRKAFH
     LVSSTFIYGW SVKPVVGESD ANTEMNALDF GYSQTKWVAE QLALAAQREG LDVRIYRPSL
     ISPTDAGFGS QDDILVRTLA FMIEHGIAAS ALNQLSLLPA DLIADHIVAL MDLPEDAGTV
     FNMTADEYYN LTDITRILSE RYGYRFSYHD IPSFAEQLNR RCTPRDALYP LVDFLTRSAD
     KIAAMRDKRY GNDQYRRARE LAKVRLREPA LTDTVDNLVR FLRSERLITE AEAEAQRSA
//