ID   A0A1X2GDD7_9FUNG        Unreviewed;       731 AA.
AC   A0A1X2GDD7;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 20.
DE   RecName: Full=SPX domain-containing protein {ECO:0000259|PROSITE:PS51382};
GN   ORFNames=DM01DRAFT_1307662 {ECO:0000313|EMBL:ORX51246.1};
OS   Hesseltinella vesiculosa.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Cunninghamellaceae; Hesseltinella.
OX   NCBI_TaxID=101127 {ECO:0000313|EMBL:ORX51246.1, ECO:0000313|Proteomes:UP000242146};
RN   [1] {ECO:0000313|EMBL:ORX51246.1, ECO:0000313|Proteomes:UP000242146}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3301 {ECO:0000313|EMBL:ORX51246.1,
RC   ECO:0000313|Proteomes:UP000242146};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC       {ECO:0000256|ARBA:ARBA00004128}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004128}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORX51246.1}.
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DR   EMBL; MCGT01000021; ORX51246.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X2GDD7; -.
DR   STRING; 101127.A0A1X2GDD7; -.
DR   OrthoDB; 1375145at2759; -.
DR   Proteomes; UP000242146; Unassembled WGS sequence.
DR   GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR   InterPro; IPR003807; DUF202.
DR   InterPro; IPR004331; SPX_dom.
DR   InterPro; IPR018966; VTC_domain.
DR   InterPro; IPR042267; VTC_sf.
DR   PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR   PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR   Pfam; PF02656; DUF202; 1.
DR   Pfam; PF09359; VTC; 1.
DR   PROSITE; PS51382; SPX; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242146};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT   TRANSMEM        637..655
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        667..684
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        704..723
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..136
FT                   /note="SPX"
FT                   /evidence="ECO:0000259|PROSITE:PS51382"
SQ   SEQUENCE   731 AA;  84548 MW;  D9132205ECC5E41C CRC64;
     MKYGRHLQEK MNPSWRIYYM DYEQFKVMLK SHSQVWTNEH EATFKQLLGK EISKVCGFLR
     DRITRSVDVM RQLEQEHQRM PQQKRANDEI EKQVIDTIFY VYDTAQFLLV NKMGFDKIVK
     KHDRYTQYNL QTQYTRAKDP ITQSSNQLDA LFIWLAQLAD QHHHRKKRQD ESTTASQARN
     RQYLKMPLNA ATFWIHPDNI DEVRTLLFLH LPPLDGKGSN RNARGSLEKL REAYSFTDVY
     WDNDDLTLYN KHVTLCNQKT RSLSLNNSCD TEHVLANTHL LKYTWNGHHP EAIQFERLTK
     TKAGGGAIMQ AGNVDQDTFT RFTQEHEHFF QASTAPPWQR VAFVDSKLSE HDALEMQQIN
     TCISQGSLEP KCKVIGQRYL FENEGVLAQL DLEMVMSRAR RDAQVKDEPF PYGQLTIHHA
     QGHHQLPGWL QLLMQSHLVY SVDRFSMFAH TVSQVYRTSR HSLNTLPWWI YLLGHDIHKP
     VTGKKAVGLT RNAAMEPLID GHRPVSFDEI HQAAPAPDTI KLSQRATFKK PAYVAVPLID
     TSVCAPVTIA PNTTTAASPG SSWFTTVWRQ QRYHQQRLAS TTSSAMMQSN PYHQHLVMPP
     PSAAISIHST LGRGRAHKDN NPKLTEPKTY FANERTFITW LQFTGLLLMI SLSLLNGKDQ
     LSHRMGILLI VVTMISTGYS LMRFQYRSWQ LRKQNYTVRY DDVTGPTCLC ILLIMSTAIN
     FYFRIIYTSA E
//