ID A0A1X2GET2_9FUNG Unreviewed; 3303 AA.
AC A0A1X2GET2;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DUF1162-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DM01DRAFT_1408497 {ECO:0000313|EMBL:ORX52050.1};
OS Hesseltinella vesiculosa.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Hesseltinella.
OX NCBI_TaxID=101127 {ECO:0000313|EMBL:ORX52050.1, ECO:0000313|Proteomes:UP000242146};
RN [1] {ECO:0000313|EMBL:ORX52050.1, ECO:0000313|Proteomes:UP000242146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3301 {ECO:0000313|EMBL:ORX52050.1,
RC ECO:0000313|Proteomes:UP000242146};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX52050.1}.
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DR EMBL; MCGT01000019; ORX52050.1; -; Genomic_DNA.
DR STRING; 101127.A0A1X2GET2; -.
DR OrthoDB; 199953at2759; -.
DR Proteomes; UP000242146; Unassembled WGS sequence.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR InterPro; IPR015412; Atg2/VPS13_C.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF93; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF09333; ATG2-VPS13_C; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 1.
DR Pfam; PF06650; VPS13_VAB; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000242146};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2..115
FT /note="Chorein N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12624"
FT DOMAIN 139..368
FT /note="Vacuolar protein sorting-associated protein 13
FT extended chorein"
FT /evidence="ECO:0000259|Pfam:PF16908"
FT DOMAIN 590..828
FT /note="VPS13 middle RBG modules"
FT /evidence="ECO:0000259|Pfam:PF16910"
FT DOMAIN 2058..2628
FT /note="Vacuolar protein sorting-associated protein 13 VPS13
FT adaptor binding"
FT /evidence="ECO:0000259|Pfam:PF06650"
FT DOMAIN 2886..3061
FT /note="Vacuolar protein sorting-associated protein 13 DH-
FT like"
FT /evidence="ECO:0000259|Pfam:PF16909"
FT DOMAIN 3067..3147
FT /note="Atg2/VPS13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF09333"
FT DOMAIN 3159..3241
FT /note="Intermembrane lipid transfer protein VPS13 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF21679"
FT REGION 828..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1463..1488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1676..1697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 92..119
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 833..848
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1471..1488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3303 AA; 369963 MW; 494B0672BBC28518 CRC64;
MLESLVASIL NRVLGNYVSN LNYDQLKIAI WNGQVNLHNL KLRRDALDKL RLPIDVTEGY
LGELELSIPW ANLKTQPVKV VIRNVYLLAK PKSESSITVE EEEERAQHLK QQKLETAELM
DSSKQSGKAD ANDSSSGGFV NQLITKVIDN LQFVMENIHI RYEDHLSCPE APFAVGLTLK
ELSAVSTNGE WEPSFIGELT NTIHKLVKLQ SLSVYWNTNA TSLAGLSQDQ ALETYTKLIP
TMQEPSPQHQ YLIKPVSGAG KIKLNKAYDQ NEAKVDATLL FEELAFGLDD EQYRDALLLV
DLFHANLKKQ EFIRFRPPTG VSPHQDPKAY FRFAGQAVLS RIHERNYQWT WDHFKTRRDQ
RLAYLDTYYA FKRAKATQQQ KDTLKKLEYD LSFEDIRFYR SIVKAKLRKE KIRLQEEKQK
NANKGWFGSW WSSNTATSTS PSADSDDGDS IVMTEEQKKE LYDAIGFDED VAAMENAIDM
PKDTMKFTVR TQLNRGSFQL WRSPHSHKHE LTSIVFENVA VEATQYLESI KVAASLGDLQ
LFDGMTPGTL YPQLIGVKKS SSSGTLSLLK QDHECDGATN DQPFLSVMYQ RKPFDKNADS
AIKVLMRHLE IIYNPQVLLG ILDFFKGPNT ESESFNALVQ VAGTTLEGFK RQTLLGLEYA
LEKHTTLDLE VEVDAPLIIV PESLLSDDSH VMIIDAGHIH VDSDLANQEI AQEFKQRRPS
ADDLERLDAL MYDKFNVALS QIKLLIGRQV KNCVAQLAHD HNAIGTDQAD NAYLLQRLDL
NLLVEKCILP ASSQFPQIKV SAQLPRAAVN LSTHKYKTLM RMIDLLLPPS SPDDAQPTNP
PSSPSSPKLI IPNQPNKNLL AQQLWGDHER EDIVISDHDS VFTTDSQPRL FRSDTSTSSV
TSTIALVTQA QQENFKLTFV VGKAVAYIYD SVQDPTSTHG NGEPTSEQLL CEVLLQDLAL
DLVNRPFDMS VQVRLKSLDV IDHMQHGSDF YYLVTSNPTL NQQDDSSPSS SNATNDDNAS
AAYLVDVRYQ RTSRQHPRFQ ELFGGYDQSV NVLLSTLTFV LTRESVLTLY NWILITFTGG
NALPTPPTSE NDPVAGGVSS PARSYLSTSA ATGTAIAPSP QPATAVSVSQ PVSNTDNSTM
RVNIHLVSVQ LIMNDLSLRL ATGTLTFGYL EILLLPSQLS VQGKFGNFVL TDDTVLAPTS
THHGGPPRDV NDYVEKIRRG KSNVPILSIE GDELLSFTYA THDPSAPQFP GYHQHLLLRM
GSFRLIFNDS FKPCLDFLSQ FLAMKASYDT QREQLMLSPT APASPSGPQP QAPNQQLFHF
DVLVKSPIVD FPVSDSDVVS AYLGEIRAVN EFATGQRLQK ATGRRLDLPL SRIHCGLYAI
SLLSMTKDKK DTSPMLGNVD IELTLESLLP PEDDSQPPPP VSANTVIRGH VTDVLLQLTE
RQYGWLLQIE QKLMTVFFPP AEDTGEPLTK PPAPSNASAQ SVQPASMAAS MLTSDSLHSL
ADLRSGKQPA ATLNKQLPLT GPAPSTPQVT MDIKVEVALI CLEVFHGCQD PTTTATRLDN
ASLCRFSFDG SQVKLLMKDD GGLMLEAQVQ SVNFYDTRKD CTSHFKDFLP AGKQLSGPQL
QLQYRQAPAT PTLVMVTVDH PQLVLSLDYI MVLKTFFLAP FQGPPEPTAA QTYAASYRHQ
NETPEQPTAP PAPVTTADQQ QQAMQFKINV VDLEIICLAH PDSPASEALV ISMDNLCFVQ
MDQLSLKAYG LRAVLCRMNH RTDSSFTLIE PFNIDLDMET APTLPGHHIT NLQIAVQRVL
VRLSYHDLML ILDIVTKVTA LLDHDSDQTS SSSLESPSPI LPDDAPASQH LALAMAAHQQ
DTLSLASATA PASSTQTTIE PYIVMSRESL SAVFDGFQLV LVEDLHDLPF LDLAVRPFTL
TATDWSRAIK ANVKVTTLMN NFNFINSHWE PLMDPYTVDL SLMQDASTKH YDFSMSTKDL
LNINITHTFL QSIMAVSSTL SSVEPLPESF QRQMKPYLIR NRTGYDLRVW NMSADAHHNS
SSVVVIKNGD DCPWTFRDWR KHREVANVTN NCVGVQVMHD NWESLYNITV DMEGKRSFRL
RNKTPTGVQD RLMVGIHLKD HVKNVTFHSG LTIKNNSNNK VEYTMINGKR KIMSPIWTLD
PKETLFIPIG LCYRPWIVLR PSDKYHWSQD KVHWSDLVHP NAPTMLTCQP HDASLPEYSF
HLHAEFDAKD PVAKQYPSMR LHIGAPIKIT NLLPFDFKWT MVNTSTDQHE AVDLCQGKSK
LLYTFPIDCP LSFVLDIQSP DYEATALKQL PWKPAEKQEG YVLNVKDKNG NLTQLFVHVG
RSKKAKHAIH IKVYCPYLIL NKVGYPISVR SYESTFGYKS VGPNLQIPQY DDRVTPQMFS
YQSIEKSNRA QISFNGSKWS KPLSFEAVGS SVDISVPYDN AQEIHAGIHI EEGTGNYNMT
KMVIVTPRFV LRNLTDTAFD FAEYKTTKDR KQIEVHETRP FYLTRSSRSF KWLCLRLQEL
QGGEVLWSTP FDIQEVGTSF IKVPISASPT TRPMLVRVSV LLKESTIFVT LHPTSDWPYL
VVNRSSTDVV VYQEPPEYDD YRSAFQPKRY VIPAGERMDY SWDLPASKAK RLILQVGKKQ
RAIDFLAIGT QMPFRYRKHQ SLSIDVAAHK TALELRLTDY KAETSLFRPT SSMGDGTEST
TVSSSRDSTL DDHFETVTIN LVDNYTIRLN LQGIGLSIIN QRSQEVLYAS IKGVDIKFTD
SNLYQSVRVS IQWLQIDNQL FSSVYPILFF PSNLPKHRGP DSNVHPTFHL ALDKVKDTSH
GVQYFKLFSV LLQEMTFEMD EDLLYSLMEF AQFDTKGETH RGSVLDESLF VAKVQSPAED
DTQALLYFEE FCIQPMRLNL SFVRTTRVST EDTETNNSPL RYLFNVLTMT IGNVNDAPLK
LNALMVENLR ASSQDLSSRI MLHYQDQVVY QIHKVVGSAD LIGNPVGLFN NLSSGFGELF
YEPYQGFITS DRPQDLGLGL ARGVGGFMRK SVFGFTDSFS RFTGSIGKGL AMATMDKKFQ
DRRHMRLTRN KPQHAIYGVT QGVTSFGTSI ASGVVGLVKQ PKLGAEESGV AGFMAGVGKG
LVGAVTKPMV GFFDLASNVS AGIRETTNMF DGSEITRERL PRLIQRDGIL RKYSQREALG
QLWLKEMADG QYNHDNYVAH SMTNNDAQAV LLSYQSLFVI STEDLTVNWH EPLDHLESVV
WQPRSTGQQP AAPDVGGWLL VRTKSGPAPK SPLLTFAEAT SGQWFATQVQ LILEYRQEEK
TRL
//
