ID   A0A1X2GGB2_9FUNG        Unreviewed;       773 AA.
AC   A0A1X2GGB2;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Zn-dependent exopeptidase {ECO:0000313|EMBL:ORX53164.1};
GN   ORFNames=DM01DRAFT_1383779 {ECO:0000313|EMBL:ORX53164.1};
OS   Hesseltinella vesiculosa.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Cunninghamellaceae; Hesseltinella.
OX   NCBI_TaxID=101127 {ECO:0000313|EMBL:ORX53164.1, ECO:0000313|Proteomes:UP000242146};
RN   [1] {ECO:0000313|EMBL:ORX53164.1, ECO:0000313|Proteomes:UP000242146}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3301 {ECO:0000313|EMBL:ORX53164.1,
RC   ECO:0000313|Proteomes:UP000242146};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC       {ECO:0000256|ARBA:ARBA00005634}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORX53164.1}.
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DR   EMBL; MCGT01000016; ORX53164.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X2GGB2; -.
DR   STRING; 101127.A0A1X2GGB2; -.
DR   OrthoDB; 67337at2759; -.
DR   Proteomes; UP000242146; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd08022; M28_PSMA_like; 1.
DR   CDD; cd02121; PA_GCPII_like; 1.
DR   Gene3D; 3.50.30.30; -; 1.
DR   Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR046450; PA_dom_sf.
DR   InterPro; IPR003137; PA_domain.
DR   InterPro; IPR007484; Peptidase_M28.
DR   InterPro; IPR039373; Peptidase_M28B.
DR   InterPro; IPR007365; TFR-like_dimer_dom.
DR   InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR   PANTHER; PTHR10404:SF46; GLUTAMATE CARBOXYPEPTIDASE 2 HOMOLOG; 1.
DR   PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR   Pfam; PF02225; PA; 1.
DR   Pfam; PF04389; Peptidase_M28; 1.
DR   Pfam; PF04253; TFR_dimer; 1.
DR   SUPFAM; SSF52025; PA domain; 1.
DR   SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242146};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        53..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          203..267
FT                   /note="PA"
FT                   /evidence="ECO:0000259|Pfam:PF02225"
FT   DOMAIN          393..583
FT                   /note="Peptidase M28"
FT                   /evidence="ECO:0000259|Pfam:PF04389"
FT   DOMAIN          641..767
FT                   /note="Transferrin receptor-like dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF04253"
FT   COILED          649..676
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   773 AA;  86068 MW;  A77A206B92E78A8E CRC64;
     MGQGQIALPV DNPTEKWYQN VHNWFRSKSD EEAPLLAGAG AGTNSQRYNY KRIAVAITLT
     TGAIAFVAFG ICQYNHRATP RLPSRPLTAQ EELFLTLPEA DRIHENLRVY TSEAHLAGTE
     SDYAQAVWTK DRFEEYGIEA ELSTYYPLLN YPIHRSLALI SGPEELRYEA SLREDPVEED
     ETSLNPDAVP TFHGYSKNGT AKGRVIYANY GTLKDFQFLV DQGVEVQGTI ALMRYGGSFR
     GLKLRAAEKF GCVGALIYSD PIDDGALNKE GFPFMHDAKP YPEGPWRSES SAQRGSVQYL
     SLLAGDPLTP GYAATKDAPR IKREDSPAMT QIPSLPLSFR DALPLLKATQ GHGVIREEDW
     KGGLDSIDYY SGPTLGEVEL VNHVDDKITP IWNVIGRING TDEADKAVII GNHRDAWVYG
     AVDPSSGSSV LLEIARSFGE LLKTGWKPRR TIIFGSWDAE EYGLVGSTEW VEDNREWLDK
     EGAVYVNMDT AVSGVHFEAS ASPSLNPLLY EITKHVTDPR TNLNVYDAWS NITTEGKGGK
     PVVGKLGSGS DFTAFLDHLG ITSVDVSFHG DYGVYHSNYD SFHWMEKFGD PTFEYHAAMA
     RIAGSLVLRL ADERVLPLYP TDYAAELIKY TADIEKYAGK TFSELHGALK RMVRRSNRFE
     NTLGRLEKKL AKYSDLKDSE LPEDLAAQVA TVNEQLVRFE RGFLDPKGIQ SRPWFKHVVY
     APSLWEGYSS QTFAAIAEAV DENDDKQVDY AAHRAAKFIK KASKSLKSHD SHH
//