ID A0A1X2GQ63_9FUNG Unreviewed; 983 AA.
AC A0A1X2GQ63;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=P-loop containing nucleoside triphosphate hydrolase protein {ECO:0000313|EMBL:ORX58889.1};
GN ORFNames=DM01DRAFT_1381530 {ECO:0000313|EMBL:ORX58889.1};
OS Hesseltinella vesiculosa.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Hesseltinella.
OX NCBI_TaxID=101127 {ECO:0000313|EMBL:ORX58889.1, ECO:0000313|Proteomes:UP000242146};
RN [1] {ECO:0000313|EMBL:ORX58889.1, ECO:0000313|Proteomes:UP000242146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3301 {ECO:0000313|EMBL:ORX58889.1,
RC ECO:0000313|Proteomes:UP000242146};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX58889.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; MCGT01000006; ORX58889.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2GQ63; -.
DR STRING; 101127.A0A1X2GQ63; -.
DR OrthoDB; 166721at2759; -.
DR Proteomes; UP000242146; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd04098; eEF2_C_snRNP; 1.
DR CDD; cd04090; EF2_II_snRNP; 1.
DR CDD; cd01683; EF2_IV_snRNP; 1.
DR CDD; cd16264; snRNP_III; 1.
DR CDD; cd04167; Snu114p; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR Gene3D; 3.90.1430.10; Yeast translation eEF2 (G' domain); 1.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031950; EFTUD2_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR044121; Snu114_GTP-bd.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR InterPro; IPR035655; U5-116kDa_C.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR42908:SF6; 116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT; 1.
DR PANTHER; PTHR42908; TRANSLATION ELONGATION FACTOR-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF16004; EFTUD2; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Hydrolase {ECO:0000313|EMBL:ORX58889.1};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242146}.
FT DOMAIN 136..346
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..48
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 983 AA; 111040 MW; 864A7F2D4426B4BF CRC64;
MDDSLYDEFG NYIGPDLEED DDEMEYDQEF SQDDLDADDQ DEQDEPMEEA SGSALMRIED
IPENQVVLHE DKKYYPSAEE VYGKEVETLV QEEDTQPLSE PIIKPVEIRK FIVQETDLPP
TTYRKEFMMD LMNMPELTRN IAVVGHLHHG KTSFLDMLVA DTHPNSPLNV EQPQRYTDTH
VLERERGISI KSMPMSFVLQ DLNDKSYLYN IMDTPGHTDF IDEVVAGLRL ADGAVLVVDA
IEGVMVNTER IIRQCIQEGI PMTLVINKVD RLILELKLPP ADAYFKLRYT IEEVNQIIKK
TPGGDHVRLS PERGNVCFAS AQVGWCFNLR SFAQMYAESY EEEIDYVQFA QRLWGDIYFN
PDTGSFHRKS QGGASKRSFV HFILEPLYKL YSQVLGEDQR DLKKTLRSLG IYLKEKQYGL
NVKELLRLVL ARFFGPANAF VDMTVRHLPS PLENARNKVE RLYSGPMDDV YASAMNTCDA
EGPLMIYITK LYNNKDATDF DAFGRVLSGT IKAGQIVRVL GESYSVDDEE DMMVQRVSNT
WIYESRYRME VEGVPAGGWV LLGGVDSSIT KTATVVDHKA SQNNHIFRPL RFPAAAALKV
AIEPMNPSEL PKMLDGLRKI NKSYPMVITK VEESGEHIVL GAGEMYVDCV LHDLRRMYAE
IDIKVSDPVV RFCETVVETS ALKCFAETPN KKNKLSFIAE PMERGLPDAI ESGKINLRWP
AKKLGGYLEE HFGWDVLATR SIWAFGPDDM GPNVLMDDTL PTEVDKKLLF SIKDSMRQGF
QWGAREGPLC DEPIRGVKFK IIDAVVASEP IHRGGGQIIP TTRRVCYSSF LTATPRLMEP
VNYVEIQAPA DCVSSVYAVL QRRRGHVTAD VPKAGSPLYT VKAYIPLIDS FGFETDLRTH
TQGQAFCQQA FDHWQIVPGD PLDASVVLKP LETSTAQQLA RDFMIKTRRR KGLSEDVSIT
KYFDDPMLLA LAESDILGVG SSE
//
