ID A0A1X2GT05_9FUNG Unreviewed; 862 AA.
AC A0A1X2GT05;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 13-SEP-2023, entry version 25.
DE RecName: Full=RhoGEF-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=DM01DRAFT_1332728 {ECO:0000313|EMBL:ORX60601.1};
OS Hesseltinella vesiculosa.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Hesseltinella.
OX NCBI_TaxID=101127 {ECO:0000313|EMBL:ORX60601.1, ECO:0000313|Proteomes:UP000242146};
RN [1] {ECO:0000313|EMBL:ORX60601.1, ECO:0000313|Proteomes:UP000242146}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3301 {ECO:0000313|EMBL:ORX60601.1,
RC ECO:0000313|Proteomes:UP000242146};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORX60601.1}.
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DR EMBL; MCGT01000004; ORX60601.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2GT05; -.
DR STRING; 101127.A0A1X2GT05; -.
DR OrthoDB; 23973at2759; -.
DR Proteomes; UP000242146; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00014; CH_SF; 1.
DR CDD; cd05992; PB1; 1.
DR CDD; cd13246; PH_Scd1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010481; Cdc24/Scd1_N.
DR InterPro; IPR033511; Cdc24/Scd1_PH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000270; PB1_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR Pfam; PF06395; CDC24; 1.
DR Pfam; PF00564; PB1; 1.
DR Pfam; PF15411; PH_10; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00666; PB1; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF54277; CAD & PB1 domains; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS51745; PB1; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000242146}.
FT DOMAIN 209..383
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 407..529
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 778..862
FT /note="PB1"
FT /evidence="ECO:0000259|PROSITE:PS51745"
FT REGION 530..772
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 366..393
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 530..549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..570
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 695..772
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 862 AA; 97418 MW; FCEC5637481BB9D3 CRC64;
MAAMALKRRS PNLGALPTAP IMIDSSLPST PSIYSTTKTL TNPPAPAGGS LYHTCRAVLD
QLKSVPGMED ILALPPTTPT TEPTTPTAGL QGGDPLTRLW QLCRRGSPLC ILYNALQPAK
PLNVDQDPTL NQLNICKASV YHFIVACRQE LAFPEDEMFT ISDLYQDDTN GFVKVVNTIQ
RILNILDDRG IITVKSLDDG NDADGPKDTR DKVVMELLET ERKYVQDLEI LQNYMRELHV
QKVLPPDTIH YLFGNLNSLV DFQRRFLIQL EEMAEMTAEE QRFDALFLQN EEAFSVYEPY
CANYYSAQDL VVQETPKLQK LEHILNPIYQ LPSMLIKPVQ RICKYPLLMS ELIKSTNREW
AHVSEMEQGL EAIKRVTEKV NETQRQHENI QAVVDLKKKV EDWKSINIDN YGSLLLQEKL
SMTNGDYTKD LHAFFFERAL LFCKENRDSS RNRLTKSNTL SIKKKRAGSL QPKYLILISR
VITVHNTSQQ GVWTLNVDYK DREVERMTLR FRNEEQLKLW ETTLNKITAS NKSNVPNTHL
MSMPLNQGDN ISYLDDEDDE EDEFDEDEDD QEIHPSRSRS NSVSAQLHHA RSKVGLNGEK
ISPRAYATTP GMNLSPLPRN SSTQSSPTAG PANTTDPTVD HGFYPASPPN SKPASPTTPR
SHHPHLHQHH PSPLWQQRHA STAGHEDYPS MNDDTPKGRS YSQSSASYAS NLPPTRVRSQ
SSPNIHKNSS QPQWEDLPQM PINSRTYYSN PSHPTSPTLA AQQQQSPPLG SVVTNGDTLK
VKLSYNDGIY VVVCPLDIRF AELMDKVEKK IKLVANLQPN DVLRLKYQDE DEDFITINSD
DDVQMAFESR GANTTVNLFV SH
//
