ID A0A1X2H152_SYNRA Unreviewed; 867 AA.
AC A0A1X2H152;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Ras guanine nucleotide exchange factor domain-containing protein {ECO:0000313|EMBL:ORY91079.1};
GN ORFNames=BCR43DRAFT_566659 {ECO:0000313|EMBL:ORY91079.1};
OS Syncephalastrum racemosum (Filamentous fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Syncephalastraceae; Syncephalastrum.
OX NCBI_TaxID=13706 {ECO:0000313|EMBL:ORY91079.1, ECO:0000313|Proteomes:UP000242180};
RN [1] {ECO:0000313|EMBL:ORY91079.1, ECO:0000313|Proteomes:UP000242180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2496 {ECO:0000313|EMBL:ORY91079.1,
RC ECO:0000313|Proteomes:UP000242180};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY91079.1}.
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DR EMBL; MCGN01000011; ORY91079.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2H152; -.
DR STRING; 13706.A0A1X2H152; -.
DR InParanoid; A0A1X2H152; -.
DR OrthoDB; 1332918at2759; -.
DR Proteomes; UP000242180; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000242180}.
FT DOMAIN 428..547
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 602..851
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 202..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..340
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..665
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 96680 MW; A2A0299EBB6B5E60 CRC64;
MEMVSPENLV LEKLQHVDLA SVFCGLNYNS HRGLAHCEDF ISALSTIITL LPQTILGTTL
SSTRSSVDRP LSDASSKFAA SVNNAITTNS LAKLPGRSKS SKRHSSSARV VASSLTAATP
SASDGDPLSA LLTTVQQEAN AILEHLRYLK SCLADDETSE KVRKYLLAKS ENMSVFEIIR
KAILLHAHQL LDAMDVVAKN ARKTKNRGSR QDDLYGTGNG NNSTARQASP QRSTSYVTSS
VSSSLHSSTV RYRSNSNKPR PWSQPCVTDD YGMVWDDASS ASVSSESKLN RTGTNAREVM
KSLLAIRFVR RRSSTRSDSS AAPESESKLV SPTSPFSSSW AATSGTLRRL SKRKKKPTSL
FALDQQGRPI LSAPSSSDDE EPYLQHITQP FLCSFSNAKL LEDANVVRVY ENGEVVMVFD
TSNKSQLSSA RLIASTVDKL LSELTSTSAA MQDPEFADVF LLTHHFFIDD MLLFQRLVEK
YHLSALREQS RILQAILRWV DIQYADFIKN DNALLHKLYR FLERLPGQDE TKRALYKAMD
PQVRGKRRHA DRLLSEKVCI EDISPLPFWS TSSLTTSSLS TTTSDLFLAS SAAEPSALSV
LCPHDIARCL TLADFDLFRS ITAYEYLHGR WRTRRLSDYD KSISSNVEDS DDNEGDEDDD
DVNEDGIGAL TNRANMLTHW IAHEFHLVKS SKQKRVLLRK LITVAKLCTE WNNFHTAMVI
ISSLQTAPRL LEDVSLPSRE AAALAELEAL LDVTNNMGTY RQALAAVVTM PVLPFFPLVL
KDFTFLLDGN PTEHQPGLIN FEKFRSLKYA VDTVLNYRTA DYWFASSDSS WRRHGHQENV
MEMLDGRMRS LGSCYTSNHH CDLRHGK
//