ID A0A1X2H170_SYNRA Unreviewed; 999 AA.
AC A0A1X2H170;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=MutS protein homolog 3 {ECO:0000256|ARBA:ARBA00029792};
GN ORFNames=BCR43DRAFT_498646 {ECO:0000313|EMBL:ORY91177.1};
OS Syncephalastrum racemosum (Filamentous fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Syncephalastraceae; Syncephalastrum.
OX NCBI_TaxID=13706 {ECO:0000313|EMBL:ORY91177.1, ECO:0000313|Proteomes:UP000242180};
RN [1] {ECO:0000313|EMBL:ORY91177.1, ECO:0000313|Proteomes:UP000242180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2496 {ECO:0000313|EMBL:ORY91177.1,
RC ECO:0000313|Proteomes:UP000242180};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY91177.1}.
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DR EMBL; MCGN01000011; ORY91177.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2H170; -.
DR STRING; 13706.A0A1X2H170; -.
DR InParanoid; A0A1X2H170; -.
DR OMA; HIAPCEL; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000242180; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000242180}.
FT DOMAIN 853..869
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 91..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 598..625
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..42
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 999 AA; 113187 MW; 3505327A7BB9ADB2 CRC64;
MSKKKQQQLT LSSFFKPKTQ QKDPEESLPQ SAASTSREAT ASLPAINIEK YALGSNTDID
NAPDNETESD LKVKRHARFV ERFGQLQEKR EEKRRRILQE EEEERSLPSS MPTLKDIGPG
NVKWSPLELQ VLELKERYPG VLLCIETGYK YQFFGDDAKV ASRILHIAHF ISRNFYVASV
PFHRIDVHVR RLVLAGYKVG VVRQSETAAL KAAGENRSGP FQRQLDQLYT KGTFVDEMAA
TEDTASRSNY LMCIVEEKKG GGGPDERVQL GVVAVQTATG DIAYDSFEDG YMRSELETRI
LHIEPCEFLL PHSLSKATEK VIKQLSQPRS GAKNEKVRIE RLPENDEFCT YYNASFARVS
DFYAKPGSTE NDALYASILN LPDTVIKALA CTIDYLTQFG LEHVLHLTKY FTHFSARTHM
LLNGNTLANL EIYRNSTNFT EQGSLFWILN RTMTRFGKRL LRKWVGRPLV DVRHLNERID
AIDELLRTEN PKKAQVVSLL KHLPDLEKGL SRIHYGRSSP SEVVQVLDAL LTISTTFLNT
ARQEALRFES ALLNSLFDPL PTIHDDVVSF RDAIDTKVVL KPDCKIHLFQ SEEKWPEIPR
QKRNIAHVEE ELEEHLRDMK KTTKLPVDYV NVAKDEYLLE IKNSLVPKVP SNWIKISGTK
AVSRFHSPFI IQKLKEREQH RERLVLAAEE AYHEFLREIS EKYETFRDVV LGLAQIDCLL
SLAAVAQQAN YVKPTFTDRI QLKIVGGRHP MVEQFVGGSY VANDTDFDAD SCRTMVLTGP
NMGGKSSYIR QVALIAIMGQ IGSYVPAESA ELGILDAVYT RMGAMDNMLA GESTFMVELH
EASDIMKQAT PRSLVILDEL GRGTSTHDGM AIAYAVLKHF ITQIKSITLF VTHYPFLAEL
ADQYPESTVN SHMSFFEEDE GGESAQVVFL YKLVRGVATR SYGLNVARLA ELPKQVLAIA
QEKAMAMEKK VMERSEQRRT ARAQEKLRKI MTDNNAMEQ
//
