ID A0A1X2H1K7_SYNRA Unreviewed; 569 AA.
AC A0A1X2H1K7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=VHS domain-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=BCR43DRAFT_480107 {ECO:0000313|EMBL:ORY91305.1};
OS Syncephalastrum racemosum (Filamentous fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Syncephalastraceae; Syncephalastrum.
OX NCBI_TaxID=13706 {ECO:0000313|EMBL:ORY91305.1, ECO:0000313|Proteomes:UP000242180};
RN [1] {ECO:0000313|EMBL:ORY91305.1, ECO:0000313|Proteomes:UP000242180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2496 {ECO:0000313|EMBL:ORY91305.1,
RC ECO:0000313|Proteomes:UP000242180};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY91305.1}.
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DR EMBL; MCGN01000011; ORY91305.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2H1K7; -.
DR STRING; 13706.A0A1X2H1K7; -.
DR InParanoid; A0A1X2H1K7; -.
DR OMA; PDNYEPN; -.
DR OrthoDB; 460229at2759; -.
DR Proteomes; UP000242180; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0016482; P:cytosolic transport; IEA:UniProt.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd16998; VHS_GGA_fungi; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.160; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.60.40.1230; -; 1.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR008153; GAE_dom.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR038425; GAT_sf.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR47180; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR PANTHER; PTHR47180:SF1; ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00790; VHS; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR PROSITE; PS50180; GAE; 1.
DR PROSITE; PS50909; GAT; 1.
DR PROSITE; PS50179; VHS; 1.
PE 4: Predicted;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000242180};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 12..148
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 175..301
FT /note="GAT"
FT /evidence="ECO:0000259|PROSITE:PS50909"
FT DOMAIN 459..569
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
FT REGION 332..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 63976 MW; C5690ECDA2DFE757 CRC64;
MSAPLQDFIE GACSPSRYEP DLALNLEICE MINKKQGNAP REAAMAIVRL VNSKNLNQAM
LALTLLDNCV KNCGYPFQLQ IATKEFLNEL VRKFPERPAP FPNPVIQRVL YMIKEWKVAL
TDMSRHKDDL IHIKDMYRLL RFKGYRFPEL RDASVAALAP SQSLKSAEEL EEEDRVAQSA
KLQELIRRGR PQDLVEANHL MKIMSGFDQR QRPNYKQKFE EELHKIQEKV ILLYEMLENV
KQGEQVTRNE TLMELKNASQ NAQPKIQKLI TEEEDNEKIE NLLTLNDMIN NAMAKFADIQ
KGIFDTQYEI SGKPPKQTEE TPEPQQAISL IDLDDGPSET SSSPQQAQKS GNVMDDLSEL
FGQSASVSSP ATSTNTGFNL GSLMNVSPPP QHQHHQHQQQ QQSMQQDEDP LAFLGRPAIA
PPPAVSPTLS SSSMGTPVAS GHASQYSHDI PSGNNGQQTA HPPIHLVNKN GLEIMFEVIQ
SDTTYRLKGY FSNKSTAPME HLCLRLAAPK SMQLKMEPQS SEVVPPKSER SVTQSVSVLN
PNKEPLRLRY KVTYQQFGVD MELVGDYSP
//
