ID A0A1X2H5V5_SYNRA Unreviewed; 786 AA.
AC A0A1X2H5V5;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Ras guanine nucleotide exchange factor domain-containing protein {ECO:0000313|EMBL:ORY93767.1};
GN ORFNames=BCR43DRAFT_516785 {ECO:0000313|EMBL:ORY93767.1};
OS Syncephalastrum racemosum (Filamentous fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Syncephalastraceae; Syncephalastrum.
OX NCBI_TaxID=13706 {ECO:0000313|EMBL:ORY93767.1, ECO:0000313|Proteomes:UP000242180};
RN [1] {ECO:0000313|EMBL:ORY93767.1, ECO:0000313|Proteomes:UP000242180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2496 {ECO:0000313|EMBL:ORY93767.1,
RC ECO:0000313|Proteomes:UP000242180};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY93767.1}.
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DR EMBL; MCGN01000008; ORY93767.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2H5V5; -.
DR STRING; 13706.A0A1X2H5V5; -.
DR InParanoid; A0A1X2H5V5; -.
DR OMA; HIAKWVA; -.
DR OrthoDB; 1369821at2759; -.
DR Proteomes; UP000242180; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF348; GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED; 1.
DR Pfam; PF00071; Ras; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000242180}.
FT DOMAIN 369..492
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 581..786
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 262..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 515..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 89198 MW; 82F44157481E8576 CRC64;
MWLHQKLALS FDRAWKKATR RQKASTKASP HTARHLPQET AITVAVVGCA HIGKTSLIRQ
LQRQKQRRHQ LRRGATMMFS RRKSSSIFTF DATTASPTLS LSHGFNGSAV PHMTFLEFDS
STFQNNSPNF PEHILSAIQA VLVCYDTTNR DSMDCLPDLL NIFCSREMPC ILIGLKTDLT
SKCQVDPQLG CDLASLFDVQ GMELSALSDT VQVERIYHAL VRLTYERTTC LDQTSFEAAE
NEEHNCPGAE VEETMSTAAS ARGKGLPSET QYRRHTSPPI RTAVKSLPIT PSPPPSPVIT
KRLSEPIFMN KVPHKSVRSA PSSPQLQRTS RRTTENNAQL RRRKSERRSV AASVVRRGSS
RLVNSIRRRR TTPCSPSLND ILDCVLCSEE DPDEPRMIVI LVTFFRRFMK PRELVRVLIE
RFDHDCHGKF PLPTLQQKRI RSLLCFWLSH HWTDFVLVQT RQALVFFLSR MSRRKELQGI
CDVLMPLAMR EAPEARDDPD ACWGLTDPVS MRNKKDSGYA ESFHPHHQSP DTSSPAPNES
RFSLVLTPIF APHRVESAEF GGLSYLTFSG ATKCDEFFSL TDICVAEQLT WLESDMFRKI
KPRDFLRYIW SPHNPLSAML AHARYITSWV TMTIVTQHTR ATQTDAIEKF ICIAEALRGL
ANFNTLPAVL TGLQDESVQK SEAWTCVRTD LVALYTRLEQ VMRDTNNGER HPKDDDEPSI
PHIETALERL LSIESMETDL TDGAINWTKY VRMGTIIDQM MRHQYPPYTS IQLDFSVLCI
VAESAA
//
