ID A0A1X2HHI3_SYNRA Unreviewed; 1996 AA.
AC A0A1X2HHI3;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=BCR43DRAFT_454648 {ECO:0000313|EMBL:ORY98518.1};
OS Syncephalastrum racemosum (Filamentous fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Syncephalastraceae; Syncephalastrum.
OX NCBI_TaxID=13706 {ECO:0000313|EMBL:ORY98518.1, ECO:0000313|Proteomes:UP000242180};
RN [1] {ECO:0000313|EMBL:ORY98518.1, ECO:0000313|Proteomes:UP000242180}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 2496 {ECO:0000313|EMBL:ORY98518.1,
RC ECO:0000313|Proteomes:UP000242180};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORY98518.1}.
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DR EMBL; MCGN01000003; ORY98518.1; -; Genomic_DNA.
DR STRING; 13706.A0A1X2HHI3; -.
DR InParanoid; A0A1X2HHI3; -.
DR OMA; AYERTIM; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000242180; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000242180};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1031..1564
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1667..1984
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1964..1996
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 1996 AA; 227595 MW; 0B81DD116319D463 CRC64;
MDGLEGPYNE FVKADKILRE MVEEVLSKET DQDDNEAQVS PALDVLRSND DGSLLLNRLV
SSFVHRVEER LYTIAKAETR PRRSVPSSRR RLHSLSPYRQ PSAMTSEKAA GVINLLLFFS
GVVEKLPRNL GIFMDGTSLW QSLSLFSEGS LINYPNGCTA LSTALVALWE KFNRSSICRS
SYQAEQYLCC ILRVMNALCA ASTFNHIPQL SDCVTKLFAP TQLRVTDQDT MLSLLESLSR
HKSNDSTEYY IQAVVLKVAC ILMVHMVEIP WISTYLKDLS KILQLRVLAT EADVLLRQLE
NAKSPDMDTS IAYESMDISQ ITTASDEQGT QQYPKEIIKV WNPLMDLIPG LLSVVDMEPS
QANAALDQLQ ILSSELQLPP NLLLAGKEQA VTEILTRYLG INMQISDRLA GFYGLDIKSL
LQSELQYAIP YAFRQSDDHL VMVMVSYLQT DTRTLVESGI VFILVDLLLS TNAAVSQTGF
DKLKQVYQSE DAPAELLRSH RTKVSAQLAM HLAIPPLRAK AQNALEMVIK SCGDLVPTAL
PEYMSTIVLA FLHEVDDYLY EKRRGRSGRA SANALKALNE VMGILGTRTK EHAPRFMALI
STVGEIPGLH TDAFMLWDRL IQELHSDDLH NHFSPILVAL LDLYTLFDAR GRMRISDVIW
DMIRRCDADK ITPYMLPVIP DFDDLKSLKL FVDEKQQALQ PEDIVVHFLA QAKSYDVAST
LLALGHLKTV LENHGPLHEA VLQHQSSLIS TLLFLSRRNI EQRIHREAAI CLGMLGAVDP
SRCNVKPLDE TLIIIDFGSD KETRRFILKL IVAQLIPAFH AANDTLIHQR LQYTMQTLLK
LGGFSEHIAK RTQDGQDIRE AWKTLPVAAK ALLTPLLRSS YKATYSCIPQ ASPIYPTASN
FQIWVQTWYF QLQAAMQGRT KAIFDACIPV VISGNTAVTV WLLPYMVSHV LFTGSPQDKK
SIALEVESVL EINSRPDVVN ETLRQLSLQI VVSVTEYCRK WIRQVQRSAK GVLPTAVESY
RSFLNTFPND KMAAASYLSQ AYAQALMHME MHIRSYKDHE DAIRKEDLDM LRQIYPHMDD
SDSMEAIFEF YSQPLSVEET VSKLVSGDHW NDAKAFYEDM QQWDDPKEAV NGLFQCYSVL
GDYVGMYAQA QLLRDNYAGL PKMRSRLNAY TQESLLHIGA WDRLERVLNE PSEDIFSVRL
AKAMLHIRKG HYYDAFSQIN EARQDQSMDL ANFGTDSYRR CYKSVLRLQI LQDLEDYQIA
FETAYKEDRL DLLNHLHIQW EKQFNLFAPS YEVRSMMLEL RHIVAFQMHD HGKGTSAWEA
NSWLLRAKLA RKAGYMETAN DSLVKAERLG ATDVEVERAK WLWLKGKQEE AYKHLNTCRK
LSAKGLLLRA RYFQRLPETN INRVYAHYRA ASKEGPTYEK IAFMLGRFLD NWLEQRSQSL
GSKWRLPNII KVTEKMIESY SEALCLGSRY NLESMPRLLT VWFQLAQKPM EEGRQEAFVN
GTKIIREKLP GMPAYQFLHV LPRVISWLSH ENAVVGDILM EIVHKVFTAY PRTTIWSLQA
ASHSSKENMR SRANAIINRV KSSQDTAYIS KIIHDAEEFC SGIYELTYSR MDMQENSQRI
DPRSKIGKLK DLSIAIPNQR AFIPTLPETV DQDYIPFADD IPTIRCIAPQ VTVMRSLQQP
KKIVLQGSDG RQYPFLCKKN DDLRKDARMM DFCFMINKFL EKDPEARQRK LYIRTYAVLP
LGENWGLLEW LNNLNPLKAI VSSLWQAMGI EPRAILLTAK QQLEKRPAEE QIVIFRKLVQ
RCPSVFYRWF LEKFPEPSQW FVCRSRYVKT LAVMSIVGYI LGLGDRHAEN ILFDATTGDC
VHVDVNMLFD KGKHLGVPEI VPFRLTRNLV GAMGPLGYEG LFTKSCQVTL DVLRLHRGQL
LSVFETLVYD PISEWHSRQR INTEEQLQAT AKKELSKIQN KISSNKTVKQ EVASLIATAS
DDTNLAQMFV GWAPFI
//
