ID A0A1X2I5S6_9FUNG Unreviewed; 1245 AA.
AC A0A1X2I5S6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BCR42DRAFT_441510 {ECO:0000313|EMBL:ORZ09953.1};
OS Absidia repens.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=90262 {ECO:0000313|EMBL:ORZ09953.1, ECO:0000313|Proteomes:UP000193560};
RN [1] {ECO:0000313|EMBL:ORZ09953.1, ECO:0000313|Proteomes:UP000193560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1336 {ECO:0000313|EMBL:ORZ09953.1,
RC ECO:0000313|Proteomes:UP000193560};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORZ09953.1}.
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DR EMBL; MCGE01000026; ORZ09953.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2I5S6; -.
DR STRING; 90262.A0A1X2I5S6; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000193560; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000193560}.
FT DOMAIN 116..296
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 328..513
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 65..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 942..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 994..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 994..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1245 AA; 141084 MW; E0F18B5801B5ABF7 CRC64;
MWTSSEQQYT NSQTNGWLEE EEAFLDQFTS KQQESTNAYT VQSIEGITPT NRSFNYCSTK
TFLPPNPDYG HQTANTSSPL ASTSSNHLRS VMEIPKEYQP IFKYSYFNRM QSEAMDQLLH
SNENIVVSAP TGTGKTVLLE MAMIRCLLVY QTQQNYQQGS IKMIYMAPTK SLCAEKVAHW
KNSFGPLGIV CEEFTGDSDY ATIDSIKNSN IIVTTPEKWD SMTRRWIDHR RLVEMIKLLM
IDEIHILKET RGATLEVCVS RMKAMDHGMR IVAVSATIPN LQDITTWLNA SALTFSEEYR
PIFLERYVYG YPSRGTNSYA FEKSLDWKLL DIIVKHGDNK SVLIFCSTRT ATQSACDTLL
KLMDRKNITL KLPNDNVELK NKKLYGFVQR GIGFHHAGLD STDRHVVEQL FLSRKIGIVA
TTSTLAVGVN LPAHLVIIKS TKGYQNGGLE EYSDIDILQM IGRAGRPGLD TSGCAVIMTT
SDMEHKFKSL ISCQSVIESS LHRNLTEHLM SEICIGTVVD MDSSTKWLGS TFLYVRVKQN
SYYYQQLYND ESLTKNPNQV MKDICLKDMK LLIDHNLVSV FGEGYNAKYE PTFYGSTMDR
YYVQFKTMVK IMQSKNWCSI KDVLELVSQS EEFETYRYNA HEKTILNDLR SNADIRFPLK
NKVSDVSDKV YVMIQCVLGE ISLYHPLIGN LMNTASHMIL QKACIIDCSA YEKDAIKLKH
SLDLYRCMQA KMWSTSPFIL KQIDGIGIQI AKSLSQRNIS SFEQLRDCDP GQLEMILHRN
PPFGTKIHSS LSFLPQYYLD LKQKPKQKYQ SQPIISLSVS IETSDHDLVD FRRIKTENLS
KRHSELNFDV KVTSPSMTVI CHLQSEDYVG LDVMKQLKPN VDPTQFITLT DPIAHSTPAP
PLIPVTLQPT ITTEQNSDAM KNDKNASLDT WIDALEDIDD SKTIKAEPST PRLKKKSTRS
KKTDNEPCKH HCKDKQSCKH QCCKRATPLE DNRITSYPEF SRSFNNNSTS PSNKQISTSS
PTDSSNRIIK SGSSGNGNCM KTQTPSHQPI PPPPPEHVSH TMTNRNHGDD DNFLDHTLLN
SRGFAHTSLS PSSVSMKIED EDTWDITDTS MDDVLCNMTI TAEKNQQEEH MHGDNDCSMF
GDLDMDMENE PLQDYFLCST ATSDAPSCDL IWADLEQAIY DADKRYHGDG AIQMDTNGND
DGDIFDLEDT ESIIGHDAQT SFQENATRLP NLIKWINDHV ETIVE
//