ID A0A1X2I687_9FUNG Unreviewed; 1367 AA.
AC A0A1X2I687;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Ras guanine nucleotide exchange factor domain-containing protein {ECO:0000313|EMBL:ORZ10212.1};
GN ORFNames=BCR42DRAFT_422982 {ECO:0000313|EMBL:ORZ10212.1};
OS Absidia repens.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=90262 {ECO:0000313|EMBL:ORZ10212.1, ECO:0000313|Proteomes:UP000193560};
RN [1] {ECO:0000313|EMBL:ORZ10212.1, ECO:0000313|Proteomes:UP000193560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1336 {ECO:0000313|EMBL:ORZ10212.1,
RC ECO:0000313|Proteomes:UP000193560};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORZ10212.1}.
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DR EMBL; MCGE01000025; ORZ10212.1; -; Genomic_DNA.
DR STRING; 90262.A0A1X2I687; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000193560; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00397; WW; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000193560};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..66
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 214..248
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 347..380
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 955..1084
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 1121..1359
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..155
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 176..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 377..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 605..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 696..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..409
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..882
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1367 AA; 153703 MW; 6BBFD6B2D44C4844 CRC64;
MAAILPEIIC RVRAIYPFQS NERASLSFQP GDEIDVLTQL DSGWWDGWSN GMRGWFPCNY
VEVIQDGAID QQYGDNIIPQ DDDDFIDHAM FTRQQPQPQQ QTQPQRPSRQ RRHNTILSVS
SSNSSSTNSS VHQPSSSKQQ QQRRPKQPPK QHQTNGMDHR LSFLAYPHQQ EDWAISRTPA
SPPVNYHDQP FNHRQFSQDD DDDDDLRSDT SQEMQLPEGW TLMLADDGKT SYYYNHLTGG
MRFKHPGLVD SDGEYDSGTE EATGHVLSGG STGMASSIRL GESSSSRPST HVFEERKIIT
ADALKRLSMA SSDNEDAVTR QLQLQPHYAY PVTPQEPSGV DDEDSVEKMM ESWVQRETPQ
GRPYFCNLIT QETTWNYDDI DPSTGHLRST QDDNSSQDTD QHDPETPTTH AHASGDGIGN
DKLGTDHHPT IEPQITWSTL SSDIALAIHQ LNTVAQQGQQ HKLMPHTSPV VESIRVMLYA
SGSMEKDVSQ TQDPALREPR RAVMASLSKL VLSAKMASEA TSANATSSPA LSLSATSETV
IKVQRDAGDV LSAVRNFVTT CQQCQVQVAH VDPRLIDTPD HIVGHPGGNN NMSNKTMIAA
MKKLQQEESH HPAITTTTST SSPTTSKSPS GTSTPAAAMK LSDSGVNMVQ KAKYPLNQDL
VVSLRTHGNQ IYGSTDALST SVSFLLTLHR MDGNNANGMS HSNSTNTRYH HHDDDDHDVG
DDYDSTPPPP PPQRHQQNQY PLYEDSAEEE NGKANVVHLF RSLSAHLSQF LGILEDIDVP
AIADVDHELP SLRSYRADKQ ILYNGVGQLF GTVQQLTDQM NERTKAVEAI DHAIARVERA
MEGILTDVGE MVLQRHAWMV RREDKNYNSN NATTTEGGGD LSLSPTTPHF YDAPEDYDDD
FIGNNPPPTP FEDSRRRGTM ASLRKRNKPS IDDSKACANW FLAPDYRPNE LLFGNDNNVK
GGTLAALVER LTMHDSFDTS YIATFLLTYR SFCTTEEFIN LLQDRYNMQA PDDLTPEQLE
IWTETKQKLV RLRVFNVLKN WLENYYDEED GFILGRLEFF TNTVVRDASP FSADQLNRLI
RKRKEAGSNQ SGLKKLVPQV FDGPLPIMPK NISHIRLLET DPLEMARQLS VCDFKLYSGI
RPIECLNKAW SRDTVKGGVP VAANVIQSID YCNRLTSWVT DSILSYDEAK KRVVIIKYWA
QVAEKCRNMN NYNTCMAIIS AFDNSAIGRL KKTWELLGNR TSQALSQIRK LMGANRNFTE
YREMVHSVNP PCIPFLGIYL QDLTFIEDGN PDYLKKSEGL INFAKRQKCA EVIQEIKQFQ
SPPYTFRLVP ELQDFIKTHL ETNRDVETLY ERSLHLEPRE TPSSTLP
//
