ID A0A1X2IJJ7_9FUNG Unreviewed; 490 AA.
AC A0A1X2IJJ7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=3-hydroxyisobutyryl-CoA hydrolase {ECO:0000256|ARBA:ARBA00011915};
DE EC=3.1.2.4 {ECO:0000256|ARBA:ARBA00011915};
GN ORFNames=BCR42DRAFT_238544 {ECO:0000313|EMBL:ORZ17699.1};
OS Absidia repens.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=90262 {ECO:0000313|EMBL:ORZ17699.1, ECO:0000313|Proteomes:UP000193560};
RN [1] {ECO:0000313|EMBL:ORZ17699.1, ECO:0000313|Proteomes:UP000193560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1336 {ECO:0000313|EMBL:ORZ17699.1,
RC ECO:0000313|Proteomes:UP000193560};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-hydroxy-2-methylpropanoyl-CoA + H2O = 3-hydroxy-2-
CC methylpropanoate + CoA + H(+); Xref=Rhea:RHEA:20888,
CC ChEBI:CHEBI:11805, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57340; EC=3.1.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001709};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORZ17699.1}.
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DR EMBL; MCGE01000009; ORZ17699.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2IJJ7; -.
DR STRING; 90262.A0A1X2IJJ7; -.
DR OrthoDB; 3639304at2759; -.
DR Proteomes; UP000193560; Unassembled WGS sequence.
DR GO; GO:0003860; F:3-hydroxyisobutyryl-CoA hydrolase activity; IEA:UniProtKB-EC.
DR CDD; cd06558; crotonase-like; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR045004; ECH_dom.
DR InterPro; IPR032259; HIBYL-CoA-H.
DR PANTHER; PTHR43176:SF3; 3-HYDROXYISOBUTYRYL-COA HYDROLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43176; 3-HYDROXYISOBUTYRYL-COA HYDROLASE-RELATED; 1.
DR Pfam; PF16113; ECH_2; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000193560}.
FT DOMAIN 60..387
FT /note="Enoyl-CoA hydratase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF16113"
SQ SEQUENCE 490 AA; 55623 MW; 212653ED2E43CDC4 CRC64;
MRLLFYRHLH SLPSPCRYCP ASSYPLKRSI HMNPFTPALP VEEAEVPKTH VLHRKLSGAR
LFILNRPEKL NALNLAMIRN IAPQLKAWDV SKLAKVILMK GANEGKFSVG DDVLDIIHKV
NTKDPDALYY FQEKSALVQM ISTLSTPYVS ILDGYACGAL GLFAHGPFRI ATEKTIFSMP
EPSLGVTFNA GSSFFLPKLD GGIGTYLALT GTRVEGLDAF YAGIASHYIP SSKLPALEDR
LIDLETSEHD IIQRVLEKFS EPLPAKRIGF SQSIRESIDR CFRHDQVEDI IKSLDEEKQT
SWTRETRHKL LSMSPTSLRV TLKALRKSKN MSLIDCLKME FDLMQKFLVT KDFHEGVEGS
LLNKPRRKPQ WDPPTLHDIT DEDIEQLYFT KPSPNSLTLP SSMDLFNYPY ARFSLPTEED
VRLAVTGEGR EFGFEGRLTT VDEVIFWFEK GHKKKAGVKE KVMDILKRKT YIIFDADNNG
KEVLQWNKAP
//
