ID A0A1X2IN77_9FUNG Unreviewed; 1099 AA.
AC A0A1X2IN77;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Ras guanine nucleotide exchange factor domain-containing protein {ECO:0000313|EMBL:ORZ19478.1};
GN ORFNames=BCR42DRAFT_218591 {ECO:0000313|EMBL:ORZ19478.1};
OS Absidia repens.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=90262 {ECO:0000313|EMBL:ORZ19478.1, ECO:0000313|Proteomes:UP000193560};
RN [1] {ECO:0000313|EMBL:ORZ19478.1, ECO:0000313|Proteomes:UP000193560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1336 {ECO:0000313|EMBL:ORZ19478.1,
RC ECO:0000313|Proteomes:UP000193560};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORZ19478.1}.
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DR EMBL; MCGE01000007; ORZ19478.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2IN77; -.
DR STRING; 90262.A0A1X2IN77; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000193560; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000193560}.
FT DOMAIN 696..825
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 861..1099
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 63..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 154..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 558..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 330..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1099 AA; 124269 MW; 12193D5BEBE32C00 CRC64;
MNHESPIYYN KQKMEDGFPT NLVKTPMLNK NDNDDDSASE LESNDEMYYM NGDHNDFMDF
AKDHSHAADS PHDKTRTTLP PTTTSATATT TTTKGYTDGN QDDWADRNDE LLTQLPSPWV
KKSVHQGGFC YYNLDTNDVV WDINDITGFR GDSSASNGSL LGSQRKEELP KSQTRSPARK
VGLKRESIIN SDEPLTWKKL SINVGLAIHN LNVAAQNSKI ESFESCTTSI VDAIRYMLLS
SGIVDKDSFH LRTNSILRAH HRTMMASLSK LILSTHTCVY SSANDITKMV SDSNELLVAT
RNFIGTSESI PIHIEHADPQ LQPHRRPSSL STTNEDKVKK HRESLATSRT NRQKYALDGD
LAENIETYGN SLCESIDGMI NSIETYKKQL DSSSADNKRT VTLDSPRSSL SALLFAQFRN
FSTQSGQFLA ILDDTDFTGF QSSELMELDM LRQNLFHGVG DFFCKLQLLT DEDVPLDGTT
DIPMQDGNSI KSTIENICLY IDKLAYDPSI RRQCSTDIGT TRSSSFGYND NENDDFDADN
NSYHTGAVGS SYFGNVQGVG RTETTTPTSS PLYSTNNVVD SSGKSESGAS ETNTSHTSQR
FSITPRQEIT SSLQRIISTS PDHPRQSNAK LKKFFGDDIP EHMPQTPPPA MDQSISVAGG
PPDVELDAAA GDTTKDEGRP WYLNYDYKPN EIVFNMEGSV KGGTLLALVI RLTLHDYVDM
NFINTFLLTY RSFCSTMELL KLLEKRYTRP PPEGLTEEEL DIWMNKKLKL IRLRVFNVLK
NWLEQYYNED DYAILDHLLE FTITTIHSTL RFSAEQLERM IKKRQESAKD GLKKMVLTQP
IAPPVPILPR NRKKFGLLDI DPLEMARQMT ILDFRLYSSI RPVECLNKAW SKDAEEDEAH
VAANIRASIE YCNQVTSWVT DAILSQPEAK KRVTLIKHWA QVAERCRQLN NFNTCMAILS
AFDNSSVGRL KRTWEMVGAR TNQILAQIRK LMGANRNFTE YRAIIHSINP PCIPFLGIYL
QDLTFIEDGN SDFLKTSKDM INFAKRAKTA EVIREIQQYQ STHYQLTPVD EIQEFIQINL
QSTRDEEQLY NESLKLEPR
//
