ID A0A1X2IT20_9FUNG Unreviewed; 1632 AA.
AC A0A1X2IT20;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=PXA domain-domain-containing protein {ECO:0000313|EMBL:ORZ21687.1};
GN ORFNames=BCR42DRAFT_408110 {ECO:0000313|EMBL:ORZ21687.1};
OS Absidia repens.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX NCBI_TaxID=90262 {ECO:0000313|EMBL:ORZ21687.1, ECO:0000313|Proteomes:UP000193560};
RN [1] {ECO:0000313|EMBL:ORZ21687.1, ECO:0000313|Proteomes:UP000193560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 1336 {ECO:0000313|EMBL:ORZ21687.1,
RC ECO:0000313|Proteomes:UP000193560};
RG DOE Joint Genome Institute;
RA Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA Visel A., Grigoriev I.V.;
RT "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ORZ21687.1}.
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DR EMBL; MCGE01000005; ORZ21687.1; -; Genomic_DNA.
DR STRING; 90262.A0A1X2IT20; -.
DR OrthoDB; 5392990at2759; -.
DR Proteomes; UP000193560; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036531; Rbsn_Rab-bd_sf.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF3; SORTING NEXIN-13; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR Pfam; PF00615; RGS; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF140125; Rabenosyn-5 Rab-binding domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
DR PROSITE; PS50132; RGS; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000193560};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 35..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 116..307
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 536..678
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 1166..1284
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 339..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 680..841
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 868..932
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 947..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1042..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1318..1366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 764..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 868..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 965..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1318..1345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1422..1439
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1632 AA; 183887 MW; A1F9C49BCA9DDBAE CRC64;
MMSSLYSSKK LFIILSILCL SLEYYWPYTL YSLVYIIRLG ILSLWGLLVL NLFVLYIYVK
YFISPTRVGQ DSRNKLDLED FRPFRFTQKH LWSRLEQQRE HENDLTSLPK LCDDNNAAIS
AAFDELLSYV LRDFIQSWFD NLSPQEHSFP KSVDDIIRSA ALELKRRLTQ VDSLSVLLHR
LIPRITAHIS EFRASEVALR GRFLERTVTE SDELDLLLAS HYAGGKLHPA LTTAAVTTTK
PTEVAYLRQL VDRLLPKLLN SEQVACAPVR VIIREIATCA LLQPTMSMLA DPDFWNQTID
TQLGMALREQ KMVRQLREVL DRHSSDIDIL NELMASDPAN LMNSTATPSS SFSSSKQEQD
FGGSSTSDNN DNNNNNSNNK QQRRMDPISQ FSSAFLGMDM DDDVAWDDQD FDPEKPKKRQ
NFGSSRMGRR TFQEFLKMIE EEKNLLDLKR ARNDVVTQLR KKKALILDRD PEEVVDGEKV
EDLIVYVNRL GVAKKRVDKR IATLSGEHVD FKTSASQFFG VRKQRPKQLP QTSGFTLHDI
LTNTAGLSYF MEFMDRRGDM VKLQFWLIVE GFRSSDNDGA KRDDRTFLQD VKMVYEMYFA
STSPHRLAIT DHLDKDLLQS IQHAQQEVMG GADNAAQWGQ AMQEMQDQLY RIQQHVLWQL
EKEHFPYFKR SDLYFKFLAS SPTPDVPPPG RRSLDDTSLY RRSSSVGQKQ QHHHRPSSHG
SNFPQHPSSD NSSSTSTHQL SPPQSTVSLG IERSLSARMT TKRTASWIRR DSGQKADSDT
EISTREKKRP SISVSTVGDG SGLLHQGSEN DASLTTSPSL TTSLNQGTHT RTYSDTVSAG
GGTSSKFLSF GRVLGSANDW WRATDFGGVS SQQHKAPSIK RSSLQGSVKS TDTEYPDSDE
ELSRSVTTLY DDQQTTPPYS SSHPLPPPPQ SLIRRNTVDA VEAELQSIID GKENSNEYEK
EERTLTTTPS SSSTSSSSLS RPNSSSAQGS LHRSPTILLG GTGSDIKSAT ADPVAFAKPV
PSWTSLGDTQ ALSQVMHHHL LDSGTQNDNQ HTTNDLSLQK SKLISGNDTK NEEEKRDHSI
KNVHLAPPGD LMLADKVNNL SDKMEKLTQQ EAIVDALIKK AEAKGKVEEL RILIKSKNMF
RRELEQMQYQ KSQYEFQESE NVLTPDRTKV SITSSTIGSD QHGDFALYVI EIQQVGFDGN
YASGWIVARR YSEFFGLHQK LKSSYASVKM IDFPSKWPLL KLQKSFVEAR RINLERYLKR
LLEQPEICHS EALRVFLSQQ NIYVPGPQRP SSSPDAGGLS PFGFFPFIPS SFQGMDLSSP
SIHPPLPSSS SSSSVTSNSS PTARHLHRSL VLGDESPLGD QRTASDKKTK GFMRHIYNTV
AAGIDDLFVT PSMLDLITQR LGEQVIGFSN DGDDNDDDDD QRTPPQNDRK SRRGATDDVG
DMVDETMHTA AAAAAAAASM GSDLKHVDVE GMTRFTEPLC DLFIEMFELK EKNNWLRRQA
VMIILQQILG GTIERKLRDT VKYLETESMV IFYFRKIMDS LWPGGAKLTF KPARKPDEKL
QTKEEANRKL STWLPDLLGN MVGRQNARKG ARRLFSVLQN QRLNQHLVYV LLDEIVMALF
PDIDDPTPLH KV
//
