ID   A0A1X2IUC8_9FUNG        Unreviewed;       239 AA.
AC   A0A1X2IUC8;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Vacuolar protein sorting-associated protein 28 {ECO:0000256|PIRNR:PIRNR017535};
DE   AltName: Full=ESCRT-I complex subunit VPS28 {ECO:0000256|PIRNR:PIRNR017535};
GN   ORFNames=BCR42DRAFT_406132 {ECO:0000313|EMBL:ORZ22409.1};
OS   Absidia repens.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Cunninghamellaceae; Absidia.
OX   NCBI_TaxID=90262 {ECO:0000313|EMBL:ORZ22409.1, ECO:0000313|Proteomes:UP000193560};
RN   [1] {ECO:0000313|EMBL:ORZ22409.1, ECO:0000313|Proteomes:UP000193560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 1336 {ECO:0000313|EMBL:ORZ22409.1,
RC   ECO:0000313|Proteomes:UP000193560};
RG   DOE Joint Genome Institute;
RA   Mondo S.J., Dannebaum R.O., Kuo R.C., Labutti K., Haridas S., Kuo A.,
RA   Salamov A., Ahrendt S.R., Lipzen A., Sullivan W., Andreopoulos W.B.,
RA   Clum A., Lindquist E., Daum C., Ramamoorthy G.K., Gryganskyi A., Culley D.,
RA   Magnuson J.K., James T.Y., O'Malley M.A., Stajich J.E., Spatafora J.W.,
RA   Visel A., Grigoriev I.V.;
RT   "Pervasive Adenine N6-methylation of Active Genes in Fungi.";
RL   Submitted (JUL-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the ESCRT-I complex (endosomal sorting complex
CC       required for transport I), a regulator of vesicular trafficking
CC       process. {ECO:0000256|PIRNR:PIRNR017535}.
CC   -!- SIMILARITY: Belongs to the VPS28 family.
CC       {ECO:0000256|PIRNR:PIRNR017535, ECO:0000256|PROSITE-ProRule:PRU00642}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ORZ22409.1}.
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DR   EMBL; MCGE01000004; ORZ22409.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X2IUC8; -.
DR   STRING; 90262.A0A1X2IUC8; -.
DR   OrthoDB; 5486880at2759; -.
DR   Proteomes; UP000193560; Unassembled WGS sequence.
DR   GO; GO:0000813; C:ESCRT I complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0032509; P:endosome transport via multivesicular body sorting pathway; IEA:InterPro.
DR   GO; GO:0072666; P:establishment of protein localization to vacuole; IEA:UniProt.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0043162; P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; IEA:UniProt.
DR   Gene3D; 1.20.120.1130; -; 1.
DR   Gene3D; 1.20.1440.200; -; 1.
DR   InterPro; IPR037202; ESCRT_assembly_dom.
DR   InterPro; IPR007143; Vps28.
DR   InterPro; IPR017899; VPS28_C.
DR   InterPro; IPR037206; VPS28_C_sf.
DR   InterPro; IPR017898; VPS28_N.
DR   InterPro; IPR038358; VPS28_N_sf.
DR   PANTHER; PTHR12937; VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28; 1.
DR   PANTHER; PTHR12937:SF0; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG; 1.
DR   Pfam; PF03997; VPS28; 1.
DR   PIRSF; PIRSF017535; VPS28; 1.
DR   SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR   SUPFAM; SSF140427; VPS28 C-terminal domain-like; 1.
DR   PROSITE; PS51310; VPS28_C; 1.
DR   PROSITE; PS51313; VPS28_N; 1.
PE   3: Inferred from homology;
KW   Endosome {ECO:0000256|ARBA:ARBA00022753, ECO:0000256|PIRNR:PIRNR017535};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR017535};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193560};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR017535}.
FT   DOMAIN          17..123
FT                   /note="VPS28 N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51313"
FT   DOMAIN          135..231
FT                   /note="VPS28 C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51310"
SQ   SEQUENCE   239 AA;  27451 MW;  61A6B49882F70A72 CRC64;
     MDSSAAHNVP QYAPNYLNQK SINMDEEIRL FTNNKDRDKY DNMADLFSII VLMEHLEKAF
     IRDSITPIEY TPQCANLIAK YKTTMNFLAD SVKDLETFMN DYKLICPAAV NRFKIGVPAT
     YEHAVEESTN NNRGKATLYV AETVSHFITL LDTLRVNRLA VDDIHPLLED LIKALNNVPG
     LSSDYEAKTT VRKWLIVLNG MKAADEITSD QARQMVFEID RSHNNFYRWL SGDHHEEQD
//