ID   A0A1X2LRX9_9MYCO        Unreviewed;       431 AA.
AC   A0A1X2LRX9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN   ORFNames=B8W66_17090 {ECO:0000313|EMBL:OSC39456.1};
OS   Mycobacterium decipiens.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=1430326 {ECO:0000313|EMBL:OSC39456.1, ECO:0000313|Proteomes:UP000193247};
RN   [1] {ECO:0000313|EMBL:OSC39456.1, ECO:0000313|Proteomes:UP000193247}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TBL 1200985 {ECO:0000313|EMBL:OSC39456.1,
RC   ECO:0000313|Proteomes:UP000193247};
RA   Tortoli E., Trovato A., Cirillo D.M.;
RT   "The new phylogeny of genus Mycobacterium.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308,
CC         ECO:0000256|RuleBase:RU003370};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC       ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC       ECO:0000256|RuleBase:RU003406}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OSC39456.1}.
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DR   EMBL; NCXP01000024; OSC39456.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X2LRX9; -.
DR   STRING; 1430326.B8W66_17090; -.
DR   OrthoDB; 9800864at2; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000193247; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06114; EcCS_like; 1.
DR   Gene3D; 2.20.28.60; -; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   NCBIfam; TIGR01798; cit_synth_I; 1.
DR   PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW   ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE        309
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        366
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   431 AA;  48104 MW;  44234238320ABFA8 CRC64;
     MADTDDTATL RYPGGEVDLQ IVRATEGADG IALGPLLSKT GHTTFDVGFA NTAAAKSSIT
     YIDGDAGILR YRGYPIEQLA EKSTFIEVCY LLIYGELPDT EQLAQFTGRI QRHTMLHEDL
     KRFFDGFPRN AHPMPVLSSV VNALSAYYQD ALDPMDNDQV ELSTIRLLAK LPTIAAYAYK
     KSVGQPFLYP DNSLTLVENF LRMTFGFPAE PYQADPEVVR ALDMLFILHA DHEQNCSTST
     VRLVGSSRAN LFTSISGGIN ALWGPLHGGA NQAVLEMLEG IRDSGDDVAE FVRKVKNREA
     GVKLMGFGHR VYKNYDPRAR IVKEQADKIL SKLGGDDSLL GIAKELEEAA LTDDYFIERK
     LYPNVDFYTG LIYRALGFPT RMFTVLFALG RLPGWIAHWR EMHDEGDSKI GRPRQIYTGY
     TERDYVTIDA R
//