ID A0A1X2LU25_9MYCO Unreviewed; 2111 AA.
AC A0A1X2LU25;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OSC40418.1};
GN ORFNames=B8W66_12895 {ECO:0000313|EMBL:OSC40418.1};
OS Mycobacterium decipiens.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1430326 {ECO:0000313|EMBL:OSC40418.1, ECO:0000313|Proteomes:UP000193247};
RN [1] {ECO:0000313|EMBL:OSC40418.1, ECO:0000313|Proteomes:UP000193247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBL 1200985 {ECO:0000313|EMBL:OSC40418.1,
RC ECO:0000313|Proteomes:UP000193247};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSC40418.1}.
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DR EMBL; NCXP01000014; OSC40418.1; -; Genomic_DNA.
DR STRING; 1430326.B8W66_12895; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000193247; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd05195; enoyl_red; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.70.250; Malonyl-CoA ACP transacylase, ACP-binding; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; NF041183; Pks2_ls1_myc; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..428
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2025..2100
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 2111 AA; 223622 MW; A978B504A92FD1BC CRC64;
METRVTPIAV IGMGCRLPGG IDSPDKLWES LVRGDNLVTE VPADRWDADD YYDPEPGVPG
RSVSRWGGFL DDVAGFDAEF FGVSEREATS IDPQQRLLLE TSWEAIEHAG LDPASLAGSS
TAVFTGLTHE DYLVLTTAAG GLASPYVVTG LNNSVASGRI AHALGLHGPA MTFDTACSSG
LMAVHLACRS LHDGESDLAL AGGCAVLLEP HASVAASAQG MLSSSGRCQS FDADADGFVR
SEGAAMVLLK RLPDALRDGN RIFAVVRGTA ANQDGGTETL MMPSEDAQVA VYRAALATAG
VAPETVGVVE AHGTGTPIGD PIEYRGLAQV YGAGTPCALG SAKSNMGHST ASAGTVGLIK
AILSLRHGVV PPLLHFKKLP DELADIETGL FVPQAVTPWP NGDEHTPKRV AVSSFGMSGT
NVHAIVEEAP AEASAPETST GDATAGRRLF MVSSTSSDAL RQTARRLATW VEDRQDSVTP
SDLAYTLARG RAHRPVRTAV VAADLPELIE GLREVADGDA LYDAAVGQGD RGPVWVFSGQ
GSQWAAMGEQ LLASEPVFAA TIAKLEPVIA AESGFSVTEA ITASETVTGI DKVQPAVFAV
QVALAATMEQ TYAVRPGAVI GHSMGESAAA VVAGALSLED AARVICRRSK LMTRIAGGGA
MGSVELPAKQ VNSELMARGI EDVVVSVVAS PQSTVIGGAT DTVRDLIARW EQRDVMAREV
AVDVASHSPQ VDPILDELAA ALADIAPMTP KVAYYSATLF DPRERPVCNA TYWVENLRNT
VQFAAAVQAA MEDGYRVFAE LSPHPLLTHA VEQTARGLDM SVAALAGMRR EQPLPHGLRG
LLTDLHSAGA GLDYSALYPA GRLLDAPLPV WTHAHLFIDT DGQEQRAQGA CTVTVHPLLG
SHVRLLEEPE RHIWQGDVGT SALSWLADHQ VHNVAALPGA AYCEMALAAA VEVFGEAAEV
RDIAFEQMLL LDEATPIDAI ASVDAPGVVN FMVQANSDGE KTRNATATLH AAADDDCPPP
AYDIAALLEA HPSSVNGTDM RESFAQRGVA LGPAFAGLAT ARTPEEEAGT VLAEVALPAS
IRFQQSAYHI HPALLDACFQ SVGAGVDAAK AAGKGGLLLP LGVGRLRVYG PTRNARYCYT
RLTKVGATGG EADLDVLDEH GTVLLAVRGL HMGTGTSESG ERDRQFSERL LTLGWQQRTL
PEVSHAEAGS WLLIDASNAA DTPDMLASAL TDALKSHGPQ GTECASLSWS IQDAPPNNPT
GLEKLGSQLR GRDGVVILFG PRGGDPDEQG LLAGREQVRH LVRITRELAE LEGELPRLFV
VTRQAQVVKS HDSGERANLE QAGLRGLLRV ISSEHPMLRT TLVDVDEHTD VERVAQQLLS
GSEEDETAWR NGDWYVARLT PSPLGHEERR TAVLDPEQDG MRLHVRRPGD LQTLEFVASD
RVPPGPGQLE VAVSMSSINF ADVLIAFGRF PIIDDREPQL GMDFVGVVTA VGEGVTGHQV
GDRVGGFSEG GCWRTFLTCD ANLAATLPPG LTDEQAIAAA TAHATAWYGL NDLAQIKAGD
KVLIHSATGG VGQAAISIAR AKGAEIFATA GNPAKRAMLH DMGIEHVYDS RSVEFAEQIR
NDTDGYGVDI VLNSLTGAAQ RAGLELLAFG GRFVEIGKAD VYGNTRLGLF PFRRGLTFYY
LDLALMSVTQ PDRVRELLTT VYKLTADGVL TAPECTHYPL ADAANAIRAM SNAEHTGKLV
LDIPRSGSRS VVVPPEQAPV YRRDGSYIIT GGLGGLGLFF ASKLAEGGCG RIVLTARSQP
NPKARQTIER LRAAGADIVV ECGNIAEPDT AQRLVSAATA TGLPLRGVLH SAAVVEDATL
TNITDELIDR DWSPKVYGSW NLHRATIGQP LDWFCLFSSG AALLGSPGQG AYAAANNWVD
VFAHWRRAQG LPVTAIAWGA WGEVGRATFL AEGGEIMITP DEGAYAFETL VRHDRAYSGY
IPILGAPWLA DLVRRSPWGE MFASTGQGSR GPSKFRMELV ALPQDEWAGR LRRLLVEQAS
VILRRTIDAD RSFIEYGLDS LGMLEMRTHV ETETGIRLTP KVIATNNTAR ALAQHLADTL
AEEEAAAPAA S
//
