ID A0A1X2LW48_9MYCO Unreviewed; 1067 AA.
AC A0A1X2LW48;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=MFS transporter {ECO:0008006|Google:ProtNLM};
GN ORFNames=B8W66_08255 {ECO:0000313|EMBL:OSC41379.1};
OS Mycobacterium decipiens.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1430326 {ECO:0000313|EMBL:OSC41379.1, ECO:0000313|Proteomes:UP000193247};
RN [1] {ECO:0000313|EMBL:OSC41379.1, ECO:0000313|Proteomes:UP000193247}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TBL 1200985 {ECO:0000313|EMBL:OSC41379.1,
RC ECO:0000313|Proteomes:UP000193247};
RA Tortoli E., Trovato A., Cirillo D.M.;
RT "The new phylogeny of genus Mycobacterium.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NTE family. {ECO:0000256|ARBA:ARBA00006636}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family.
CC {ECO:0000256|ARBA:ARBA00008537}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSC41379.1}.
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DR EMBL; NCXP01000007; OSC41379.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X2LW48; -.
DR STRING; 1430326.B8W66_08255; -.
DR OrthoDB; 7375466at2; -.
DR Proteomes; UP000193247; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProt.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd17321; MFS_MMR_MDR_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR004638; EmrB-like.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00711; efflux_EmrB; 1.
DR PANTHER; PTHR42718:SF47; DRUG EFFLUX PUMP JEFA; 1.
DR PANTHER; PTHR42718; MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF07690; MFS_1; 2.
DR Pfam; PF01734; Patatin; 1.
DR PRINTS; PR01036; TCRTETB.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 2.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS51635; PNPLA; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 82..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 110..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 169..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 398..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..455
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 44..488
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 523..631
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 808..967
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
FT REGION 978..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 111321 MW; BB51FA996104F0BF CRC64;
MPAQTVTANV AASVIDDGPV EPGRWGSRTG VPPARRRQPS SAAVLLVAAF GAFLAFLDST
IVNVAFPDIQ RHFQSDISDL SWVLNAYNIV FAAFLVASGR LADLLGRKRV FIYGVVLFTV
ASGLCAIADS VGQLVAFRVL QGIGAAVLVP ASLGLVVEAF PAARRAHGVN LWGAAGAIAA
GLGPPIGGAL VEADGWRWVF LVNLPLGVLA VLAARRALVE NRASGRRRVP DVRGALLLAI
ALGFLTLGLI KGPDWGWASL PAIGSLLAAA VAMVGFVMSS RHHPAPMVDP ALLRIRSFVA
GTGLTAVASA GFYAYLLTHV LFLNYVWGYT LLEAGLAVAP AALVAAVVAA LLGRVADRHG
YRFIIGIGAL IWAGSLLWYL KVVGSTPDFL GEWLPGQILQ GIGVGATFPL LGSASLARLA
KGGSYATASA VTGTIRQVGA VVGIALLVIL VGTPAPGAAE EVLRRGWTMA AICFVAVAFG
AVLLGRIRPV PAATAEAPPA PPVAPLGSQR PMPAPVRPPA APVAPVLKAS RELDLLAALR
SARPDAQLVE LQAGSYLFHA GDASDALYVV RSGRLLVLAG NGEKEDVVAE LGRGQVVGEL
GVLLNAPRSA TVRAVRDSSL TRVTKAEFDK IADAGVLGAL AGVLAKRQHQ TRTASQRTTP
EAVVAVIGVN SNAPVAMVAT ELCAALSTRL RAIAPGRVDR DGLERAEQAA DRVVLHAAAD
DALWRDFCMR VADRVVLVSS NPAPPSATLP ARATGADLVL AGPPAGREHR RAWEELITPR
SMHTIRRGHV ADDLRVLATR IAGRSVGLVL SGGAARACAH LGVLEELEAA GVTVDRFAGT
SMGAIIAALA ASGMDAAGVD AQIYEHFVRK SHGDYTLPRK GLIRGKRTQA ALRTIFGDQL
VEELPKHFRC VSVDLLGRRP IVHRRGPLAD VVGCSMRLPF LYAPMPYNGT LHVDGGVLDN
VPVTTLVGKD GPLIAVNVAS GGNPSPTSSG NRRRKPRVPG LTDTLLRTMT ISSAIASESV
LAQADLVIKP NPTGVGLMEY HQIDLAREAG RNAAREALPQ IMELVHR
//
