ID A0A1X3CGS6_9NEIS Unreviewed; 660 AA.
AC A0A1X3CGS6;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Glutathione-regulated potassium-efflux system protein {ECO:0000313|EMBL:VEJ21783.1};
GN Name=kefC {ECO:0000313|EMBL:VEJ21783.1};
GN ORFNames=NCTC12227_01541 {ECO:0000313|EMBL:VEJ21783.1};
OS Neisseria animaloris.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=326522 {ECO:0000313|EMBL:VEJ21783.1, ECO:0000313|Proteomes:UP000268229};
RN [1] {ECO:0000313|EMBL:VEJ21783.1, ECO:0000313|Proteomes:UP000268229}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12227 {ECO:0000313|EMBL:VEJ21783.1,
RC ECO:0000313|Proteomes:UP000268229};
RG Pathogen Informatics;
RL Submitted (DEC-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; LR134516; VEJ21783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X3CGS6; -.
DR STRING; 326522.BWD08_09465; -.
DR KEGG; nani:NCTC12227_01541; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000268229; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000268229};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 410..532
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 574..657
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 660 AA; 72626 MW; 08266B6BB639B39D CRC64;
MHTISLAPIV IVLLVAVIAV IICRKFNIPS MLGYLLSGFL AGPSVLHLIP KSEATDYLGE
IGIVFLMFSI GLEFSLPKLK AMRRLVFGLG GMQVVITILA VIGILLASGT KFNWAFAVAG
ALTMSSTAIV SRILSEKTEL GQSHGQMAMG VLLMQDIAVV PLMILLPALA GGNSGNLWLE
LGLAALKMIA TLGVLFFVGS RIMTPWFRMV AKRKSSELFM INVLLVTLGV AYLTELEGLS
LALGAFVAGM LLSETEYRFQ VEDDIRPFRD ILLGFFFITV GMKLDIQALV DGWQLVFILL
GILIALKALI IFLIAYRMRY TVGDSMKTAF YLAQGGEFGF VMLAVSSKID MVSTELEQAA
TAAILLSMII APFILNGSDK LVNKLVKSNW DMKAVDLQNM LIATMSKSDH VLIIGYGRGG
QTIGRILAQD NIPYYALDLD AERVQIARSA GEPVSFGDAK RREVLEAAGL SRAKMVVITL
NNMLETQHVL DNIMRLHPTM PVHVRAVSDD YLQVFTHMGA EEAVSDTKET SLALASYAML
GAGLSYQHVH QTIMNIRRSR YAILEDLFVG SDDESGFYDE SNSISRYAFT LTDEAYAIGK
NTNELPLKHL NIKLLFVRRH THRIEEFDEN FCLEANDILV VAGKKDKIIS FENWSLQGNQ
//
