ID A0A1X3P765_9MICC Unreviewed; 1229 AA.
AC A0A1X3P765;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=BCY76_010580 {ECO:0000313|EMBL:OSM43073.1};
OS Nesterenkonia sp. PF2B19.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Nesterenkonia.
OX NCBI_TaxID=1881858 {ECO:0000313|EMBL:OSM43073.1, ECO:0000313|Proteomes:UP000175621};
RN [1] {ECO:0000313|EMBL:OSM43073.1, ECO:0000313|Proteomes:UP000175621}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF2B19 {ECO:0000313|EMBL:OSM43073.1,
RC ECO:0000313|Proteomes:UP000175621};
RX PubMed=28408669;
RA Singh P., Kapse N., Roy U., Singh S.M., Dhakephalkar P.K.;
RT "Draft Genome Sequence of Permafrost Bacterium Nesterenkonia sp. Strain
RT PF2B19, Revealing a Cold Adaptation Strategy and Diverse Biotechnological
RT Potential.";
RL Genome Announc. 5:e00133-17(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OSM43073.1}.
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DR EMBL; MDSS02000032; OSM43073.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X3P765; -.
DR STRING; 1881858.BCY76_010580; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000175621; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.30.160.800; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}.
FT DOMAIN 45..406
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 426..745
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 66..73
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1229 AA; 135569 MW; 54EF933971C955BE CRC64;
MNSSSLATGD PVPDADSAAR VATVRHSARD IADALQRDTP PEKRLYPTPE QQDVIEAGLD
PMLVVAGAGS GKTATMADRV VWLVANGLVR PDQILGVTFT KKAAGELKER ITGRLRQLIE
ADLIAPEDIV PPELVDDART QSISELLTPA VSTYHSYANT LVGEYGLHIG LEPETQLIGE
AKAWQMVHRI ASSYERAQVL VDAEQSAGNL AGQVMQLASD CAEHLRTPDD VEAHLDVELA
RYDGWVADGA SPKKEQIALA QSLRVRREMA ELVRRFQEAK RHEGFMDFGD LLRFAAQIAM
DVPSAGAAER EKYKVVLLDE FQDTSFAQLA LFSHLYGAGI DGRGESGGVG HAVTAVGDPN
QSIYGFRGAS AGQLFDFPQA FPAVDPATGD RRAADLKQLT VAWRNGRTIL EVANRIVEPF
RPDSADSLGK PWRQHNAHLR ARLKPLSSPD GAGDGTVRVG WFSSEAEESQ AIAAQLADTL
DVLPGADRPS CAVLSRTRAQ LETVAEHLRA AGIEYELVGL SGLLRTPEVA EVLAYLRVVA
DPGRSDALIR ILAGARYRIG PKDLVQLQRA ARDLEGLRLR TDADQETADG ADAEDRYEST
ALEMDERSSL VEALERLQDD PQQAERLGLS AEGHRRLVLA KNQIRRLRQW TGLDIGVLIQ
RVISDTGLDI EVAARPWEEQ HHAARQLDAL IDEAEGYAAT ETTPDLRSFL DWLDAAEERE
RGLEQADVEP RPGAVQLLTV HASKGLEWDV VVVAGLREEK FPSKQADRWT GSNGMLPARL
RGDRRSIPQW ESDQEELRAW AVSAGFGAWK QFTEENPVYS QDVRDFTREE ERRLAYVAVT
RARHLLICTG ACFYGPSKGQ EPSEFLEEIR EVVDADGGAG QNRLAWAEVE DLTANPLAGQ
VLGAHWPYDP LAPMPIARYR KQEAPEGEAR LATMELIEAP AQVPGRRPAL TRSADLVRTA
AAELEADAGV QAQAELTPWE QEAQWIVDRV RSQRRGSGLP SFPSHISVSG VVGLAQNAKG
VAEFARRPVP VKPSQAARRG TVMHEWIEEF YQTRSRLPDI EEPGRGDEEL DDAFDLAQVK
DQFTDTEWAQ RQLYAAEIPV ETSIDGVVVR GRIDAVFGRD QDGRDLTAQD HHRWELMPSA
ERNAQMQQCQ WHLVDWKTGM VPTGKDLTEK QLQLAVYRLA FHRLYGVPLD QIEASFFYVE
HGVTVPGTDL PEADALEAHI RGARRHFGE
//
