ID   A0A1X6MLK9_9APHY        Unreviewed;       432 AA.
AC   A0A1X6MLK9;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
DE   Flags: Fragment;
GN   ORFNames=POSPLADRAFT_1071781 {ECO:0000313|EMBL:OSX57294.1};
OS   Postia placenta MAD-698-R-SB12.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Polyporales; Postiaceae; Postia.
OX   NCBI_TaxID=670580 {ECO:0000313|EMBL:OSX57294.1, ECO:0000313|Proteomes:UP000194127};
RN   [1] {ECO:0000313|EMBL:OSX57294.1, ECO:0000313|Proteomes:UP000194127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MAD-698-R-SB12 {ECO:0000313|EMBL:OSX57294.1,
RC   ECO:0000313|Proteomes:UP000194127};
RG   DOE Joint Genome Institute;
RA   Gaskell J., Kersten P., Larrondo L.F., Canessa P., Martinez D., Hibbett D.,
RA   Schmoll M., Kubicek C.P., Martinez A.T., Yadav J., Master E.,
RA   Magnuson J.K., James T., Yaver D., Berka R., Labutti K., Lipzen A.,
RA   Aerts A., Barry K., Henrissat B., Blanchette R., Grigoriev I., Cullen D.;
RT   "Genome Sequence of the Model Brown-Rot Fungus Postia placenta SB12.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; KZ110609; OSX57294.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X6MLK9; -.
DR   STRING; 670580.A0A1X6MLK9; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000194127; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000194127}.
FT   DOMAIN          10..225
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:OSX57294.1"
SQ   SEQUENCE   432 AA;  47742 MW;  32AD8EC63D72E393 CRC64;
     MAVAKRDIYL VIGGSGFLGR HIVNALLARG DAVSVFDIVQ RHHDVPFYSG DISEEGQVSE
     ALQKSGATCI IHTASPPHGM DDPALYWKVN VDGTKAVISA AVASGVSKLV YTSSAGVVFN
     GDNLVDIDER LPPPAKAMDA YNESKSKAEQ MVLEANGKGG LYTVALRPAG LFGPGDRQLI
     AGLYEVYENG QTHYQIGDNT NLFDWTYIEN AAHAHLLAAD RLRPYTPDEI AGLKEDLKVA
     LPYIDCTTGA RRIPTSECRP LGPYVTPPPN AEQITANWND HDYNGAPKPA IRGRFDQLAD
     SSLAREDNAQ LQVAGQVFFI TNGEPMYFWD VPRIAWKFFD EHFGTEKTKR SLICLPREVG
     MVLASAAEWW AWLVGKQPGF TRFRVTFSCV WRCHNIEKAR KVLGYEPQVG MEEGLKKTLE
     WWVADKQKSV KA
//