ID A0A1X6MX46_9APHY Unreviewed; 2152 AA.
AC A0A1X6MX46;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=POSPLADRAFT_1145964 {ECO:0000313|EMBL:OSX60927.1};
OS Postia placenta MAD-698-R-SB12.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Polyporales; Postiaceae; Postia.
OX NCBI_TaxID=670580 {ECO:0000313|EMBL:OSX60927.1, ECO:0000313|Proteomes:UP000194127};
RN [1] {ECO:0000313|EMBL:OSX60927.1, ECO:0000313|Proteomes:UP000194127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MAD-698-R-SB12 {ECO:0000313|EMBL:OSX60927.1,
RC ECO:0000313|Proteomes:UP000194127};
RG DOE Joint Genome Institute;
RA Gaskell J., Kersten P., Larrondo L.F., Canessa P., Martinez D., Hibbett D.,
RA Schmoll M., Kubicek C.P., Martinez A.T., Yadav J., Master E.,
RA Magnuson J.K., James T., Yaver D., Berka R., Labutti K., Lipzen A.,
RA Aerts A., Barry K., Henrissat B., Blanchette R., Grigoriev I., Cullen D.;
RT "Genome Sequence of the Model Brown-Rot Fungus Postia placenta SB12.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ110599; OSX60927.1; -; Genomic_DNA.
DR STRING; 670580.A0A1X6MX46; -.
DR OrthoDB; 5396558at2759; -.
DR Proteomes; UP000194127; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000194127};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 8..440
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2152 AA; 235439 MW; 59425DB956C9F709 CRC64;
MSCTLDTGGI VAIVGIAAEL PSGPACPSNL DYHVFCRLLL KKGKAYQTIP VERFNIHGIK
GKGLGQVVTD TGAFLKAVES FDYMEFGITN KDATSMALST RKLIETSFLS LVDSGIDYRG
KNIGCYMSGV AHDSVSVAGH EDADKQGSFG FAPAMVANRV SYHLDLRGPS VALDTACSSS
LYAMHLAVQA LRNAECEAAL VGGCQINHRM AEWLAYTQGG VLSSDGECKP FDANADGFGR
GEGAIVVVLK TLQNALKDND KIYSTVRSSQ QIRAILNGRI DSRNRRSLGP VNAAVASAQK
NAMLRAFAQA GRRPCDVDYV ELHATGSTAQ GDPTESNWVG ETFQRERELI IGSVKGNIGH
LEIAAFLASL CKVCLMVRTR LIPPTANLLV PNPSIQWGKY NLRVATEVEP LPCFAPNGRH
LISLASSGIG GANGHCVVEG PPSERRRSPR IWKSERPPPW LLVASGLSPK SAIAVQDLLC
QTDPRDHGAL SRIYGRRSRS MFWRSYALSN DGQLSSFSPA TLAPKEKPPL VFVFSGQGSQ
HYESHTGLFT ENQQERDLGN PWSIETTLPA LTIFQLALYE TLLRLGIRPH IVLGHSAGDT
AVLAASSMGS RAMAIEIAIA RGKAMARLDK EGGTMAALAC SVETVLQLIT SDTEQGSMEI
ACYNSPSAVT ISGHASRVHS VVRAASEIGI FARVLRTRTP VHSSLMEACH EEYRRLVAEV
FSRHSRSAPV ITTYSSYTGV QTNTSFDADY FWDSARGPVQ FSTAIHAILE TAPNAIFVEV
GPHPVLCTYI SSMSGDTHRA LSPTKRTEKG EECYNLIDFL GQLVVAGYTG IDFDALGCAG
DPDVDVPPFP LSRREVPYLA PTPEAIRQRQ ERNGPLNYPQ LRINSRTHPA LAEHIIKNEP
TMPAAGYIEM TGRSMLLFNW RAVDGASAVR RLWILRRNGR LRAHEFVGNN DEVDLEKIRA
RLKRVNMKDF YRGFSFFANY GPTYQRVTSC LRGVDIYGRS EALVEVRGID DDLPGAETYR
IHPAILDAAL HIMVHPNFNG CNDKHRYYLS STCGSFTLHN MVLSEPFPRT VFAHVVMTQW
FPDSITYECL LIKEDGTPLC TLQDMTCALH GHGEPLMQRF QLVYAPTDVP LSAALGVLES
EDQDIRQCTK RYTLQPVSHE GLAVPLDTGS LDDGIVTFSS DSTDLLIHYR RGEEISLQKI
LKSLDPLAPS ALWLIASDDL DGYACLGLAR SLRKEYRAWA LYTVLFDRVW TRRHRAKAIE
TLMTRGRLSE VEMIISADGV VTSPKILPLP QTTRSTEFNP ALPWKLENSQ ISHITLPPPA
NDYVTVRVIA VTTAYGSLQG FVGCVAGVDD EASVDSQEYA TKNKALSVVA CVVAALAVGV
ASFSHPQRLK QTKILVDEGD GDLCHQIIEI IVTGVTDDSL LSVYKEMAGS HSSVFAWRHP
QTGVARVIET DPCAIGDALN ASLPYTGMTE LYTQPLLLVD HIPPEVPLRT DLFERSKSYL
LIGGVGSLGV HIAAWMHQNG AREIVLTSRS DRQGLTRKGD YLSQAILRYL EKLPDLTLRT
RRADALSEED MRGLVQSLKH PLGGCFILTA ILIDHTFAML TQAEFDSPFK AKDEVFGTLK
KIVPIESLDF LIAFSSVSGL FGNAGQTNYA AANTALSGML QEYKNATSFI CPIITDAGVF
LTQSGDSYMS RIRHLSDWGM SCRVLDLCAY IEDVILRLRD GPVWQYIPAF DWNAVSASMG
PSSMYNHIVD ASALDVQGQP APDKAEGLRD IVSRLLDIAS EDLSLDVPLT AYGLDSLTAA
SLSFALRDLL PISQIQLLSG MTLANLLTLL SARLAQNPSS TTASTTDSHG IRECHHKVRE
MTQLVHKYGT FPRREMPLTS TKSRSQKVVL VTGVTGRVGA HVLKELLEDT DVELQIERTI
THVIHLERPI EDASVAVGSG YSESKWVAER LVLEATAQHC IMGTVIRIGQ MSGAANGCWK
TSEWIPALVS ASSALGCVPD GTGEVSWLPV HVGAAALVEM LDSEEPVLHL RHPHPVHWSD
IMQCIAVSLK VPMVPYQEWI GLLEGSLMQP MDRGVEVYLE PAIRILDWLR LGVQSTKNAD
HRRDNNGLSF TMAIDLGCAA STTLRDSVLT PLGPTDVDRW MRFWRINGAI VS
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