ID A0A1X6P6R1_PORUM Unreviewed; 256 AA.
AC A0A1X6P6R1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 13-SEP-2023, entry version 17.
DE RecName: Full=thymidylate synthase {ECO:0000256|ARBA:ARBA00011947};
DE EC=2.1.1.45 {ECO:0000256|ARBA:ARBA00011947};
GN ORFNames=BU14_0184s0008 {ECO:0000313|EMBL:OSX76581.1};
OS Porphyra umbilicalis (Purple laver) (Red alga).
OC Eukaryota; Rhodophyta; Bangiophyceae; Bangiales; Bangiaceae; Porphyra.
OX NCBI_TaxID=2786 {ECO:0000313|EMBL:OSX76581.1, ECO:0000313|Proteomes:UP000218209};
RN [1] {ECO:0000313|EMBL:OSX76581.1, ECO:0000313|Proteomes:UP000218209}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=4086291 {ECO:0000313|EMBL:OSX76581.1};
RA Brawley S.H., Blouin N.A., Ficko-Blean E., Wheeler G.L., Lohr M.,
RA Goodson H.V., Jenkins J.W., Blaby-Haas C.E., Helliwell K.E., Chan C.,
RA Marriage T., Bhattacharya D., Klein A.S., Badis Y., Brodie J., Cao Y.,
RA Collen J., Dittami S.M., Gachon C.M., Green B.R., Karpowicz S., Kim J.W.,
RA Kudahl U., Lin S., Michel G., Mittag M., Olson B.J., Pangilinan J.,
RA Peng Y., Qiu H., Shu S., Singer J.T., Smith A.G., Sprecher B.N., Wagner V.,
RA Wang W., Wang Z.-Y., Yan J., Yarish C., Zoeuner-Riek S., Zhuang Y., Zou Y.,
RA Lindquist E.A., Grimwood J., Barry K., Rokhsar D.S., Schmutz J.,
RA Stiller J.W., Grossman A.R., Prochnik S.E.;
RT "WGS assembly of Porphyra umbilicalis.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KV918861; OSX76581.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X6P6R1; -.
DR OrthoDB; 1118873at2759; -.
DR Proteomes; UP000218209; Unassembled WGS sequence.
DR GO; GO:0004799; F:thymidylate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006231; P:dTMP biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00351; TS_Pyrimidine_HMase; 1.
DR Gene3D; 3.30.572.10; Thymidylate synthase/dCMP hydroxymethylase domain; 1.
DR InterPro; IPR045097; Thymidate_synth/dCMP_Mease.
DR InterPro; IPR023451; Thymidate_synth/dCMP_Mease_dom.
DR InterPro; IPR036926; Thymidate_synth/dCMP_Mease_sf.
DR InterPro; IPR000398; Thymidylate_synthase.
DR InterPro; IPR020940; Thymidylate_synthase_AS.
DR NCBIfam; TIGR03284; thym_sym; 1.
DR PANTHER; PTHR11548:SF2; THYMIDYLATE SYNTHASE; 1.
DR PANTHER; PTHR11548; THYMIDYLATE SYNTHASE 1; 1.
DR Pfam; PF00303; Thymidylat_synt; 1.
DR PRINTS; PR00108; THYMDSNTHASE.
DR SUPFAM; SSF55831; Thymidylate synthase/dCMP hydroxymethylase; 1.
DR PROSITE; PS00091; THYMIDYLATE_SYNTHASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Reference proteome {ECO:0000313|Proteomes:UP000218209};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..256
FT /note="Thymidylate synthase/dCMP hydroxymethylase"
FT /evidence="ECO:0000259|Pfam:PF00303"
FT ACT_SITE 134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10016"
SQ SEQUENCE 256 AA; 27752 MW; 087C5EF80F9E4AB8 CRC64;
MAFSLRRGRF PLLTTKRVFF RGVAEELAWF LRGSTDARDL AARRVHIWDG NGSRAALDAR
GLRHRAVGDL GPVYGFQWRH FGAPYTDFDA DYTGAGVDQV AALVDGLVAD PPGRRHLLTA
WNPAAVAAMA LPPCHVLAQF YVAGGELSCQ LYQRSGDLGL GVPFNIASYA LLTVLVAAVT
GLTPGDFLHV LGDAHVYGNH GGALVEQLRR APRPFPTLTL RRPLSRGVAG LTEWAWGDLQ
VDGYEPHPAV KMDMAV
//
