ID A0A1X6WXI1_9MICO Unreviewed; 801 AA.
AC A0A1X6WXI1;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
GN ORFNames=FM110_05115 {ECO:0000313|EMBL:SLM90526.1};
OS Brachybacterium nesterenkovii.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Dermabacteraceae;
OC Brachybacterium.
OX NCBI_TaxID=47847 {ECO:0000313|EMBL:SLM90526.1, ECO:0000313|Proteomes:UP000195981};
RN [1] {ECO:0000313|EMBL:SLM90526.1, ECO:0000313|Proteomes:UP000195981}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIP104813 {ECO:0000313|EMBL:SLM90526.1,
RC ECO:0000313|Proteomes:UP000195981};
RA Peterson S.W.;
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 42 family.
CC {ECO:0000256|ARBA:ARBA00005940}.
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DR EMBL; FWFG01000048; SLM90526.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X6WXI1; -.
DR OrthoDB; 9800974at2; -.
DR Proteomes; UP000195981; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd03143; A4_beta-galactosidase_middle_domain; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR013738; Beta_galactosidase_Trimer.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR003476; Glyco_hydro_42.
DR InterPro; IPR013529; Glyco_hydro_42_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR36447; BETA-GALACTOSIDASE GANA; 1.
DR PANTHER; PTHR36447:SF2; BETA-GALACTOSIDASE YESZ; 1.
DR Pfam; PF02449; Glyco_hydro_42; 1.
DR Pfam; PF08532; Glyco_hydro_42M; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000313|EMBL:SLM90526.1};
KW Hydrolase {ECO:0000313|EMBL:SLM90526.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000195981}.
FT DOMAIN 29..413
FT /note="Glycoside hydrolase family 42 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02449"
FT DOMAIN 426..661
FT /note="Beta-galactosidase trimerisation"
FT /evidence="ECO:0000259|Pfam:PF08532"
FT REGION 569..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 757..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 801 AA; 86615 MW; 73DBCABC31709146 CRC64;
MTATDPTSSA AHPVRTAPWD ERLGFGAAYY HEYHLSDRLD EDMDLMAAAG FTLIRVGESV
WSTWEPSEGV FDLDWLEPVL DAAHARGIDV IIGTPTYAVP PWLRIAYPET ALELATGAPK
PYGARQDVDY SHPTFRRLAE RVIAKIVERY REHPAVVGWQ VDNEPGLALI HNEGAFRGFV
ESLRKRFGGD VEELNRRWGL VYWSHRLTDF DELWRPEGNT TPSYDLAWRR WQAELSHDMI
RWQTELVRSL VPEHHVITTC IAANQSGQDV TVIADPLDVA GANVYYAAQE GLALPGPDEL
HPMGAPAWIL WSGAAYPSYL ADVARGMKQG PFVVTETNAT NIGFSADQLP SWPGQRRQAV
WTLLMRGARM VEYWHWHTNR FGVETYWSGV LGHSLQPARA YDELAAVGAE LAALREDVTG
LTPLSDVAIL VDAPSRWAIE CQPPFHAGDT ATFFGDRDAS EKMLAQTYRG LFDAGLSADI
VAPHQLPEDP AAMVREHPVL IVQSLYIASD ALLAHLVAYA EAGGHLVLTP RTGVADEDAV
VRAEVLPGAL RGPAGVRYTE STAVRRPTAV GGAHADAGPA TGGQAPVEEA AGSRPTIAGG
ALWYADCLET EGAEVLAGYG DDPFLGRFAA VTTARCGEGR VTTIGCVPDR PLSASLARWI
ARTSLPEDPW RSTIAGLAPA PEGGDGPVER AHPTLSHSAA RLRDGRVLHA LHNWSWEPAE
VGAPTACTRR QPDGTSVELA AGAPIVLGPW DTALLITDAP DSDAAPRSPE PSAASRPSAS
PRTTGTTRTT STTRPTGTEE S
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