ID   A0A1X6Z1Y7_9RHOB        Unreviewed;       431 AA.
AC   A0A1X6Z1Y7;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
GN   Name=gltA_1 {ECO:0000313|EMBL:SLN37798.1};
GN   ORFNames=ROA7450_01821 {ECO:0000313|EMBL:SLN37798.1};
OS   Roseovarius albus.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC   Roseobacteraceae; Roseovarius.
OX   NCBI_TaxID=1247867 {ECO:0000313|EMBL:SLN37798.1, ECO:0000313|Proteomes:UP000193061};
RN   [1] {ECO:0000313|EMBL:SLN37798.1, ECO:0000313|Proteomes:UP000193061}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CECT 7450 {ECO:0000313|EMBL:SLN37798.1,
RC   ECO:0000313|Proteomes:UP000193061};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
CC         Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.16;
CC         Evidence={ECO:0000256|ARBA:ARBA00000308,
CC         ECO:0000256|RuleBase:RU003370};
CC   -!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
CC       from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
CC       ECO:0000256|RuleBase:RU003370}.
CC   -!- SIMILARITY: Belongs to the citrate synthase family.
CC       {ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
CC       ECO:0000256|RuleBase:RU003406}.
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DR   EMBL; FWFX01000004; SLN37798.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X6Z1Y7; -.
DR   OrthoDB; 9800864at2; -.
DR   UniPathway; UPA00223; UER00717.
DR   Proteomes; UP000193061; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd06114; EcCS_like; 1.
DR   Gene3D; 2.20.28.60; -; 1.
DR   Gene3D; 1.10.580.10; Citrate Synthase, domain 1; 1.
DR   Gene3D; 1.10.230.10; Cytochrome P450-Terp, domain 2; 1.
DR   InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
DR   InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
DR   InterPro; IPR002020; Citrate_synthase.
DR   InterPro; IPR019810; Citrate_synthase_AS.
DR   InterPro; IPR024176; Citrate_synthase_bac-typ.
DR   InterPro; IPR036969; Citrate_synthase_sf.
DR   InterPro; IPR010953; Citrate_synthase_typ-I.
DR   NCBIfam; TIGR01798; cit_synth_I; 1.
DR   PANTHER; PTHR42871; CITRATE SYNTHASE; 1.
DR   PANTHER; PTHR42871:SF1; CITRATE SYNTHASE; 1.
DR   Pfam; PF00285; Citrate_synt; 1.
DR   PIRSF; PIRSF001369; Citrate_synth; 1.
DR   PRINTS; PR00143; CITRTSNTHASE.
DR   SUPFAM; SSF48256; Citrate synthase; 1.
DR   PROSITE; PS00480; CITRATE_SYNTHASE; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000313|EMBL:SLN37798.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000193061};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR001369};
KW   Tricarboxylic acid cycle {ECO:0000256|ARBA:ARBA00022532,
KW   ECO:0000256|RuleBase:RU003370}.
FT   ACT_SITE        308
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
FT   ACT_SITE        366
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SQ   SEQUENCE   431 AA;  48537 MW;  9A0A7FCAFCEA86DC CRC64;
     MADDKKTATL SIGGQDYELP VFTPTAGPDV IDIRKLYAQA GVFTYDPGFT STASCDSTIT
     YIDGGKGELL HRGYPIDQLA EKSHYLEVCY VLLYGELPSP AQLEEFESRI TNHTMLHEQM
     HFLFRGYRRD AHPMSIMVGV VGALSAFYHD SLDINDEWQR EVASIRMISK MPTIAAMAYK
     YTLGQPFVYP RNDLDYASNF LRMCFAVPAE DYEVNPILSR AMDRIFTLHA DHEQNASTST
     VRLASSSGAN PFACIAAGIA CLWGPAHGGA NQACLEMLQE IGSVDRIPEF IERAKDKSDP
     FRLMGFGHRV YKNTDPRAKV LKQSADEVLE LLGVEDNPLL QVAKELERTA LHDEYFIEKK
     LFPNVDFYSG IILEAMGFPT SMFTPIFAVS RTVGWISQWK EMISDPQLKI GRPRQLYQGA
     TFRDYVDIEK R
//