ID A0A1X7C7C8_9ACTN Unreviewed; 6320 AA.
AC A0A1X7C7C8;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Non-ribosomal peptide synthase domain TIGR01720/amino acid adenylation domain-containing protein {ECO:0000313|EMBL:SME91433.1};
GN ORFNames=SAMN02745830_00410 {ECO:0000313|EMBL:SME91433.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SME91433.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SME91433.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SME91433.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR EMBL; FWZW01000001; SME91433.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:0009403; P:toxin biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 3.
DR CDD; cd17646; A_NRPS_AB3403-like; 1.
DR CDD; cd02440; AdoMet_MTases; 2.
DR CDD; cd19543; DCL_NRPS; 2.
DR CDD; cd19540; LCL_NRPS-like; 2.
DR Gene3D; 3.30.300.30; -; 7.
DR Gene3D; 3.40.50.980; -; 10.
DR Gene3D; 1.10.1200.10; ACP-like; 5.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 6.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR010060; NRPS_synth.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 5.
DR NCBIfam; TIGR01720; NRPS-para261; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 5.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 5.
DR Pfam; PF08242; Methyltransf_12; 2.
DR Pfam; PF00550; PP-binding; 5.
DR SMART; SM00823; PKS_PP; 5.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 5.
DR SUPFAM; SSF47336; ACP-like; 5.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 11.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS00455; AMP_BINDING; 5.
DR PROSITE; PS50075; CARRIER; 5.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 5.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000192930};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1130..1204
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2202..2276
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3654..3729
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 4701..4776
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 5766..5840
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 22..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6320 AA; 683007 MW; 3044754EDBD2DA35 CRC64;
MCGSEEVLTF WRRTLTPLPA EISLPVDRPY GPEPDAGSRE SRVLTGLPAA SDTEALAAFV
ALLHRHSSAL DLTVGHDGLP VRVSADHEPA FRELVRRVRE SYDEAVTHRV PVSLLVDELS
PRPTRGGGLL LNAAFGTADR PAGELPGPVD LLLETGDGEV RATYDPALFD AATVDRLLGH
YRTLLADALE RPDAPISGLA LMDADEYRQV VLDWNATEHT VPARTWPEMF AEQVRTRPDE
TALVLGDEHL TYAELDERAN RLAHALIARG AGPERIVALA LPRSVDLFVT EVAILKSGAA
YLPIDHDYPA DRVAYMLDDA APVCLVTDRE TARDLPGRDG TRTLALDAPD TVAELAQRPA
HDPADADRGA PLTVLGAAYV IYTSGSTGRP KGVVLAHTGV AKLVATQSER FGIGPHSRVL
QFASPSFDVA FWDLCLGLLS GGRLVVVPAE LRVPGAPLAD YAHRHGITFM ILPPALLAAM
PDDVELPPTA TLLAGTERVS PELVGRYARG RMMFNAYGPT EATTNSTLGL CDPDIPAGSI
VPIGVPDPGT RAYVLDAALR PVAPGVTGEL YLGGAGLARG YLGRAALTAE RFVADPFGAP
GERLYRTGDL VRWRPDGRLE FLGRADAQIK IRGFRIEPGE IESVLRSHPA VDQVTVVARE
DRPGDRRLAA YVVPALDTPR DDDPDAGVEE WRELHELLYR AAGSEGAPAH SDGLRENFAG
WNSMYDGRPI PVEEMREWRA ATVAAIRGLG DVRRVLEIGV GSGLILSAIA PDCESYWGTD
LSAEAIAALR GQLAAFPELA AKVELSARPA HDTDGLPAGH FDTVVINSVA QYFPSADYLA
DVLRRAATLL APGGRILVGD VRNLRLLRTL RAAVETLRVA GGPDPEDKTA LREAVERSVR
WEGELLLDPD FFAALDGFDA DIRLKRAGHH NELSRYRYDV VLRATDTAIA VPDEREVPWS
ETGGPAGLTA LLAERPARLR ITGVPNARLT DDLAALRALD GSSREAAAGT DPEDLHALAA
AHGYRAALTW NGASDDGAFD AVLTVDDGDG PLAGLYRTVG GYPHANRPAP FRDVTALMRT
LRGHAADRLP DYMVPAAFVP VHALPVTPSG KIDARALPAP DYAAMSSGRP PRTPREKLLC
ALYAEVLGLD SVTAEDDFLA LGGDSITAIQ LLVRARESGL RLTTREVFRH RTVEALAQAA
AARTDEHTGA SDAPLVEVDA AELAEIQGAD PLAVEELLPL TPLQQGFFFH ALTGGADGDT
YVVQQVLDLT GPVEGPTLRR AAQRLLDRHA PLRAGFRQRP DGTPVQVITR DAVLPWREVD
LTAQDATVRE SLGAAVAEDE RAAGFDLAAP PLLRCALIRL GDRRSRLVLT FHHIIADGWS
LPVLHRELMA FYGTDEPALP DVAPYRGFLR RLAEQDRDAA RDTWRTALAG LEEPTRLVTA
PAVAGAVRPA HVRVELTERT TALLTDRARE HGVTLGTVVQ AAWGLLLGTL TGRDDVVFGT
TVSGRDGEVD GIASMVGLFI NTLPTRFRWA PRATLADLLT RLQDEQARLL DHQHLGLAEI
QRLTGHAGEG ELFDTLVVFE NYPAEADLRD ATGTVRIAAD AFNDAVHYPL ALIVKPGRRL
DLRLKHHAER LDADRVRVLG DRLTRLLEAI AEDPARTAAS LDPLTADEAL RAHPHGEEHE
VPATTLAEAF TDQVRRTPDA TAVVFGTERL TYAELDARAT ALAARLAERG ARPGEFVAVA
VPRSAELMVA LLGVLKSGAA YLPLDLDYPA DRVAHMLTDS GAGTVITLAA TADRLPDTDG
TRVLLLDTDE QGTAAAAPVP ARPDDPAYLI YTSGSTGRPK GVVVTHRAIV NRLAWMQGAY
GLTADDRVLQ KTPSSFDVSV WEFFWPLLEG AAVVLARPDG HRDPAYLAAL VRAERVTTMH
FVPSMLEAFL QHDQITEDPA WAASLRRVLS SGEALPAGAA ARWHALTGVP LHNLYGPTEA
AVDVTHHRYD GTDEGPSVPI GRPVWNTGLR VLDTCLRPVP DDVPGELYLT GVQLARGYHA
RPGLTAERFT ADPYGPPGTR MYRTGDLVRR RADGVIEYLG RTDRQVKLRG NRIELGEIEA
ALTALPEVAQ SAVTVRDNAL VAYVVPVPST ATAPSTATVP SAPSAQSAPD VTALRDALAE
VLPAALLPGA WVVLDALPLT PSGKLDRAAL PAPRAVRAES RAPRTPREQL LTEIFAAVLK
LPEAGVDDDF FLLGGDSITS IAVSSRARRA GLVLDPRDVF EHRTPAALAA AATLEAAETA
EPAPAFTLTE EEHARVERLA PGRVEDVWPL APLQEGLFFH STYDDGTLDV YTVHESFDFA
ERVDTARLTA ATRTLLARNP SLRAGFTSDG LRQPVQFIVR DAEIPLTEVD LSALTRDEQD
VRLRELMDEE RSRRFDLSRP LLFRMLLVRL GEGRGDRLVI GRHLILWDGW SAWLFLDQLF
ALYETAGDPA GLAEPGSYRD YLTWLERQDD TRATGAWRTA LAGFEEPTLL APAVSDRGLE
PVIPEQLDTL LDPEVSERLR ETARRHGLTL NTVLNAAWGL ALAAVTGRTD IAFGTTVAGR
PSEVPDVENV IGMFLNTVPA RIAFDPREPV LDLLRRVQGE RLALMPYEYL GLGVLQAETG
HRRLFDTLFV LRNADTEERL AELRDRHGAT AVANVDATHY PANLVVTPGE RVRVTLAYRP
DLLEDAYARA LLERFVLLVG RLVADPAAPV GSLDGLLPAE TALLAREDAE RREPVPHETI
ADMLAAQALR TPHDTALVFG SATLTYAELD ARCNRMARLL IRHGAGPERV VALGLPRSID
TVVALFAVLR TGAAYLPLEL DHPAERLSLM LADARPLLLL SNRAVSATLT GDTPRLLLDD
PGTAAELAAQ SADPVTVSFS LDHPAYIIYT SGSTGRPKGV VTPYLGLTNM QLNHQKEIFA
PAIASAGGRR LRIAHTVSFA FDMSWEELLW LVEGHEVHIC DEELRRDAIA LVAYCEEHRV
DVVNVTPTYA HLLLEEGLLE GHRPPLVLLG GEAVTETVWN TLRDTEGTYG YNLYGPTEYT
INTLGGGTHD SATPTVGKPI RATRARILDT WLRPVPEGVA GELYIAGVGL ARGYLDRAGL
TAERFVADPY GLPGERMYRT GDLVRRRADG NLDFLGRTDD QVKIRGHRVE LGEIETALAQ
LPEVSRAAVL ARDDTAAPGT KRLVAYVVPA EPDAEARESA EREQIGEWQE IYSAEYTEIG
TALFTEDFAG WDSSYDGTPI PVEHMREWRE ATVTRIRELN PRRILEIGVG SGLLLSRLAP
DAEAYWATDF AAPVIRKLTE GVRTVPELAA KVELRCQPAE DTEGLPTGYF DTIVINSVLQ
YFPSLDHLHQ VIRGALGLLA PGGALFLGDV RDLRQARVFQ AGIQAARAEP DTAPDALRRA
VERGLALEKE LLVDPDWFTT LGVGVDLRTK AGRHHNELTR YRYDVVLYEG DALPVDDAPA
VDWTGPDALR ARLDGTGPLR VCGIPDARTA GDLATLRALD TGRPTGLDAT GVEPEDLRDL
AHATGHRLLT TWSGEPGRYD AVFVPGTATP RTSGLYRARA DREDTPYANT PAAGRGHTAL
VRRLRDDLGQ RLPGYMVPAA FVVLPGLPMN DNGKLDARAL PDPEPAVALS AGRGPRTPVE
EVLCRLFAEV LGLPRTGAED NFFDLGGHSL LATRLISRAR TELGAELAIR DLFEAPTPET
LALRAEVGHP ARPVLAPVTD RPARIPLSAA QRRLWLVERI AGDGVAYNFP LVFRLRGALD
IEALRAALRD VTDRHEALRT RFLEVDGEPY QWITAPGEAE PEFEVTEGTE AGLAAWIEEA
QRRPFDLARD LPVRAGVLRL AADDHVVAVV LHHITTDEWS DRPFLADLNH AYTARTAGHA
PERAPLPVQY ADYTLWQENL LADLGERQLA YWTSALSGLP EEIPLPLDRP GAARATGHGA
VVRATLPDAT GAALRDLAAT HQVSMFMLFQ AATAALLHRL GAGDDIPLGA PIAGRTDSAV
DDLVGFFVNT LVLRTDLSGT PTFAELLDRV RESALAAFEH QDVPFDRVVE AVNPVRAADR
NPLFQVMLGY HHRPDGDPDL FGLDTEWFDM DNGMAKFDLD FTVVDHGPGR DMALLLEYAT
DLTDPGTAAD LASRFVDLLA QVARDPARPV DTLRVLTDAE ETAAATLWNA TDRPLETRSV
PEILDDVVRA RPDAPALATA HSRLTFRELG AQVDAVARLL RERGAGAERV VGLALPRHLM
VPALLGVLKS GAAYLPLDPE YPADRLEFML RDTAPLCVLT TAELAPKLPE GPSVVLYDEA
AAYEGTSADT PAPAPSAAAY VIFTSGSTGT PKGVVGTHRG LSNFFGAHHD DLIRPAEGAL
GRTALRAAHA ASFSFDGSWE PLIWLLAGHE LHVTDEATLA DPAALLALLG REDIDFLDVT
PTYLRELLHH GFLEPGAPLP RVIAVGGEAT PAPLWERLRA LPGVQVHDLY GPTESAVDAY
GWHSDTAGRH AAPLDNIRAH VLDAALRPVP VGVTGELYLA GEGLARGYLG RPDLTAERFT
ADPYGPPGTR MYRTGDLVRR RRDGSLEFQG RADGQVKLRG FRIETGEIEA LLAGLPGVAT
AAVVVREDTP GVPRLVAYVL PAADRDPDPA ELRARSAAAL PSHMVPAAFV TVPALPRTVA
GKLDVRALPA PDLGALTSGR RPRTPREDLL CEAFAAVLGV PEAGVDDDFF ALGGHSLLAM
RLTARIRAAL GAEVSLRTVF DAPTPARLAR HLTDAAAPTR PALTAREHTG PLPLSSAQQR
LWVLYQVEGP SATYNIPSAW RLTGDLDVDA LRAAVHDLVE RHETLRTVFP DDQGRARQHV
LTPDEARIPF EVTDTDEDLL PELLAEAGAY GFELDREPPL RVQVFRTGDQ DWTLLLLLHH
IAGDEWSEGP LNRDLALAYA ARTAGRAPDW EPLPVRYADY TLWQREVLGD EQDPESLSAR
QIAYWKQTLA GLPEELALPF DRPRPLESSY RGGAADLSLD AELGAALHAL ARDNGVSVFM
VLQAAVATLL TRLGAGTDIP VGSPISGRTD AALDELVGFF LNTLVLRTDT SGDPTFRELL
ARVRASDLAA YDHQDVPFER LVDALNPARS LARHPLFQVM VVHLVSGDDE TGLPGLRAHR
DDVEGTTAKF DLSFDFVERA DGTGVDGVLE YSADLFDPAT AQSFADRLRR LLKAVTADPD
RTLGRIDILD PDERTRLTGG WHSTPLASPP TTVPALFEAQ ARRHGELPAA ASDGVELTFA
RLNADANRLA RLLVEAGAGP ERFVALALPR TAHFLTAVLA VHKAGAGYLP LDPDAPAERT
ADVLADAGPV LTLSTADLAA TLPPGATPLL LDDPAIRARI AAHDPADLTD ADRTAPLTPR
HPAYVIYTSG STGRPKGVVV THETLGNLFH SHRETLYGPA VEAAGRAHLR VGHAWSFFFD
ASWQPQLWLL DGHCVHVLSE EVRRDPELVT RAVLRHRLDF LEVTPSFFAQ MADSGLLSGD
DCPLAVVGVG GEAVPVALWQ RLAALRGTEA FNLYGPTEST VDALVARVRD SERPLVGRPV
TGTRAYVLDD LLQPLPPGVP GELYLAGGGL ARGYLGSPGL TAERFVADPF GPPGSRLYRT
GDLARWTADG RLDYLGRADD QVKIRGFRIE PAEIEAALTT HPAVGQALVT VRQDGPRKQL
VAYVVPVPET AADPAQLRAH VAARLPDHMV PAAVVVLERF PQLANGKLDR AALPAPDFTA
LSSGRAPEGP VEELLCTVFA EVLGLERVGV DDDFFALGGD SIVAMQLVGR ARAAGLRISP
RLVFRHRTVA ALGAVAETAD TAAPRPADDG TGTVPLTPVM HWLRELGGPF ATYHQAALVR
TPAELDLPGL TAVLQSLADR HDLLRATLVR PTREDTEDWS LHVPPTGTVD AAGWLDRVDV
TGLDAQELGD TVRRHTEAAR ALLDPDTGAM VRAVWFDAGD RPGRLLLMAH HLVVDGVSWR
VLLPDLATAW QQVRAGRPAE VPSVETSFAR WSRLLTTLAQ APEREAELPV WTEVLDGGTE
PLPLLREFDP DRDTTATQRE VVLRLPADRT GPLLSAVPAA FGAAVNDVLL AGLALAVADW
RRRSGGADRT LLVDLEGHGR EEELAGDDVD LSRTVGWFTS VFPVRLDAGP VDPAEAFDGG
VAAEEAVRGV REHLASLPAN GVGYGLLRHL NPRTRDVLAG REQARVEFNY LGRFGIPEET
DWSYAPEEDA ADIGPEAAMR EGHALSINVV TEDRADGPVL AAHWSYLEGL LARETVEDLA
GTWFKALEGL VACAERKQQR
//
