ID A0A1X7CKN9_9ACTN Unreviewed; 607 AA.
AC A0A1X7CKN9;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NAD-dependent formate dehydrogenase flavoprotein subunit {ECO:0000313|EMBL:SME98406.1};
GN ORFNames=SAMN02745830_00978 {ECO:0000313|EMBL:SME98406.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SME98406.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SME98406.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SME98406.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|ARBA:ARBA00034078};
CC -!- SIMILARITY: Belongs to the complex I 24 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00010643}.
CC -!- SIMILARITY: Belongs to the complex I 51 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00007523}.
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DR EMBL; FWZW01000001; SME98406.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7CKN9; -.
DR OrthoDB; 9805533at2; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0010181; F:FMN binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR CDD; cd03082; TRX_Fd_NuoE_W_FDH_beta; 1.
DR Gene3D; 3.10.20.600; -; 1.
DR Gene3D; 6.10.250.1450; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR Gene3D; 1.10.10.1590; NADH-quinone oxidoreductase subunit E; 1.
DR Gene3D; 3.40.50.11540; NADH-ubiquinone oxidoreductase 51kDa subunit; 1.
DR Gene3D; 1.20.1440.230; NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain; 1.
DR InterPro; IPR001949; NADH-UbQ_OxRdtase_51kDa_CS.
DR InterPro; IPR011538; Nuo51_FMN-bd.
DR InterPro; IPR037225; Nuo51_FMN-bd_sf.
DR InterPro; IPR002023; NuoE-like.
DR InterPro; IPR041921; NuoE_N.
DR InterPro; IPR019575; Nuop51_4Fe4S-bd.
DR InterPro; IPR037207; Nuop51_4Fe4S-bd_sf.
DR InterPro; IPR019554; Soluble_ligand-bd.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR43578; NADH-QUINONE OXIDOREDUCTASE SUBUNIT F; 1.
DR PANTHER; PTHR43578:SF3; NADH-QUINONE OXIDOREDUCTASE SUBUNIT F; 1.
DR Pfam; PF01257; 2Fe-2S_thioredx; 1.
DR Pfam; PF01512; Complex1_51K; 1.
DR Pfam; PF10589; NADH_4Fe-4S; 1.
DR Pfam; PF10531; SLBB; 1.
DR SMART; SM00928; NADH_4Fe-4S; 1.
DR SUPFAM; SSF142019; Nqo1 FMN-binding domain-like; 1.
DR SUPFAM; SSF142984; Nqo1 middle domain-like; 1.
DR SUPFAM; SSF140490; Nqo1C-terminal domain-like; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
DR PROSITE; PS01099; COMPLEX1_24K; 1.
DR PROSITE; PS00645; COMPLEX1_51K_2; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW FMN {ECO:0000256|ARBA:ARBA00022643}; Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000192930};
KW Translocase {ECO:0000256|ARBA:ARBA00022967}.
FT DOMAIN 523..570
FT /note="NADH-ubiquinone oxidoreductase 51kDa subunit iron-
FT sulphur binding"
FT /evidence="ECO:0000259|SMART:SM00928"
SQ SEQUENCE 607 AA; 63957 MW; 490FEA87644154C8 CRC64;
MDLRFGDSKP TDEERAAVDA LLGPAESAWE GADRTDADLR WARGGRAARD RRDLLLPGLH
AINDRIGWIS EGALDHLCRR LTVPPAEAYG VATFYAMFSM RPRPATVLHV CTDLACAAAG
AGELCAGVES RLGPGSGVSV ERSPCLGLCE RAPAALAIRA GDPVRTAVAA PADVETAVRA
GTAPDAAPEE PSAATAVPQA GQDGLVLLRR VGVVDPSSLD DYRAHGGYTA LRRAFALGPA
GVIREVTDSG LLGRGGAAFP TGRKWQATAS QPDRPHHLVC NADESEPGTF KDRVLMEGDP
YALVEAMTIA GYATGAHRGY LYLRGEYPRA LHRMRHAVEQ ARARGLLGDD VLGQGFAFDI
EIRRGAGAYI CGEETALFNS IEGYRGEPRS KPPFPVEKGL FGKPTVENNV ETLVNVLPVL
TMGAPAYAAI GTGRSTGPKL FCVSGSVARP GVYELPFGAT LGEVLELAGV RPGLRAVLLG
GAAGGFVRPD ELDLPLTFEG TREAGTTLGS GVVMAFDGTV PLPRLLLRIA EFFRDESCGQ
CVPCRVGTVR QEEALRRLAD RSGAAAADDV ALLRDVGRAM RDASICGLGQ TAWNAVESAI
DRLGAYE
//
