ID A0A1X7D2H7_9ACTN Unreviewed; 463 AA.
AC A0A1X7D2H7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA (cytosine-5-)-methyltransferase {ECO:0000256|ARBA:ARBA00011975};
DE EC=2.1.1.37 {ECO:0000256|ARBA:ARBA00011975};
GN ORFNames=SAMN02745830_01482 {ECO:0000313|EMBL:SMF07582.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SMF07582.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SMF07582.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SMF07582.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016, ECO:0000256|RuleBase:RU000416}.
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DR EMBL; FWZW01000002; SMF07582.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7D2H7; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR031303; C5_meth_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00675; dcm; 1.
DR PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR PRINTS; PR00105; C5METTRFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00095; C5_MTASE_2; 1.
DR PROSITE; PS51679; SAM_MT_C5; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000192930};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT ACT_SITE 114
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 463 AA; 51188 MW; 5F80F774ECC19D17 CRC64;
MLDALRWLSQ RTWKEITMSA ADREQRLDVI EICAGAGGQS FGLHKAGFTH LLAVELDKHA
AHTLDQNLRR VLKEDGVDVP DELVRVGDVA DPSVWDPDSY RGKDIALLAG GVPCPPFSIA
GKQLGSSDER DLFAWAIELC GRIRPKALLL ENVRGLSANR FSGYRQAVLD KLHDFGYIAS
WKLLHASDFG VPQLRPRFVL VALLPEYAKY FDWPQGNPDD APSVGETLRD LMGANGWEDE
EVRAWADKAN DIAPTIVGGS KKHGGADLGP TRAKKAWAEL GVDAMGVANE APKPGFKPVN
GATGPKLTTQ MVARIQGWHG EFAHWEFLGL KTSVYRQIGN AFPPPVARAL GESIKNALLK
TGKPHTLVET SNTVHDPVYK LLRQHSRPLT VEQIIIRLAK NGVAMDQPEA ERRLNHLGHD
FELEKTERKS GELAYSLGEF KAFVGQDDHQ RHDLFTQHRA KIS
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