ID A0A1X7F0Y7_9ACTN Unreviewed; 779 AA.
AC A0A1X7F0Y7;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits {ECO:0000313|EMBL:SMF43812.1};
GN ORFNames=SAMN02745830_03459 {ECO:0000313|EMBL:SMF43812.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SMF43812.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SMF43812.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SMF43812.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; FWZW01000007; SMF43812.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7F0Y7; -.
DR OrthoDB; 9804819at2; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03213; ABCG_EPDR; 1.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR48041:SF91; ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A; 1.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00498; FHA; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000192930};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 531..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..584
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 604..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 648..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 677..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..80
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 139..189
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 225..460
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 779 AA; 84170 MW; 4479C57ADD7C3CCF CRC64;
MVDRWPAAPT APELVLETDT GSTVIDPARA YRVGRDPNSD IVIEDARVSW HHAVLRPDGD
HWTLEDAQST NGTWADGRRI RQWTVGPGSV IRFGSPSDGP CAVLADRPAP QRPASVSMPA
HTVTFRSPAT VHPLPTRTVR IGRAAENDLV VDDLVVSRRH AELRALPGGG YEIVDLGSHN
GTFLNGAPVS RAPVGPGDIV GIGHSAFSLV GDELQEYVDT GEVSLDVQDL TVAVDRGRKV
LLDHVSFPVG EKCLLAVVGP SGAGKSTLLN ALTGLRPADQ GTVVYDGRDL YRDYAELRQR
IGLVPQDDIL HAQLTVRAAL GYAAELRFPQ DTAKAERRER VEEVIRELGL EQRADQHVHS
LSGGQRKRVS VALELLTKPS LLFLDEPTSG LDPGMDRSVM HMLRDLADDG RTVVVVTHSV
LSLDVCDRLL VLAPGGRIAY YGPPGEALEF FDCEHWPEAF EAFERDQGRD WAGEYRASPQ
HRQYVLDDDA QPRLTRSGPV VMLPPARPRS RGAQLGTLVR RYAAALAADR TFLAVMIALP
FVMGAMARAL AGGELTRETA LNALLILCVG GVLTGAANAV RELVKERVIY QRERAVGLSR
SAYLMSKVVV LGTVTVVQAV VLTLVALLGV DLGAPDGKGV LLPPLVEIAF AVALLAFTAM
MLGLVISALV RKEEVTMPLL VLLAIVQVVF CGALLKLDGV VGLEQVSWLV PSRWALGAMA
GTIELSRTVP GDLTADPMFR HATDVWLLNI AMLVVLSAVL GFVVSRLLRR REPAVMRRS
//
