ID A0A1X7F239_9ACTN Unreviewed; 780 AA.
AC A0A1X7F239;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Thioester reductase domain-containing protein {ECO:0000313|EMBL:SMF44294.1};
GN ORFNames=SAMN02745830_03493 {ECO:0000313|EMBL:SMF44294.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SMF44294.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SMF44294.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SMF44294.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FWZW01000007; SMF44294.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1X7F239; -.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR44845:SF6; BETA-ALANINE-ACTIVATING ENZYME; 1.
DR PANTHER; PTHR44845; CARRIER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000192930}.
FT DOMAIN 60..136
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 780 AA; 84226 MW; 01F4753EB27F585E CRC64;
MRDMNEDPTA NAGQRAVAEA IERGGADAGG LTVTDLLAMV TRKEEPESEV AAAPVPHGVP
DVEGLAAAIA EAAGRYLPEG RLAPDADFFD AGGSSVHAVE LAAELERDLG VELDLDDVFA
DARPVGLARR WLETAGDAAN LALPVAAPAP VAVPAPRPAV VASPSASAAS ARQDDLDQIL
ADLALADRLP FVRRPEPVAP RRILLTGATG FLGGHMLLDL LRHSDAHVYC LVRAADLEAA
TARLGESLRR HLLPWNAEIR RRVTVLPGDI RGPRLGLSDE LWHTLTEELD SVVGVAAAVD
FLRGYRSLRG SNVIGALTLA ELAATGRPKP LHHISSIAVF NEVGITSLGE DDPLAHVDRL
VAGYDQSKWA AEVALRRARD HGLVVSALRP GGIGGHSRTG AHNPQDLSSG LIAAFGRFRT
VPAFRHLNVA PVDWVSRAAV AVVCEPDAWG FDYNLTGVPQ TLDDVVRDMA FGGMHVRVQD
WEEWRTDTLA RLEAEPVPEL TFLTRVLNSP TALKLCEATL TGPAAEGTRT AALVEALGLP
PAARYDARAQ LKTFEQLAGD GLARLPHKDD QPYLWFSETT QGGVRPVDGS TGGTPCSMSL
TLSLASMYQL VRERRLDVTG TVDCPAVHPE PLTVVRGDVW VRPEEGIPQS HGLKHQLLRY
RLQLRDVEGE LWWLEGHKYA RARRDLWRQT RALTVELGRE GEQAAVTGEV VVPADSYVRD
QVDGIRVAPH LTAQEKRAAK LTWLAWFGVE MGRGLLGPFA RAGADLLDLR RTTNPTEHRR
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