ID   A0A1X7FEK8_9ACTN        Unreviewed;       350 AA.
AC   A0A1X7FEK8;
DT   05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2017, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=O-methyltransferase {ECO:0000313|EMBL:SMF50468.1};
GN   ORFNames=SAMN02745830_03984 {ECO:0000313|EMBL:SMF50468.1};
OS   Streptomyces sp. Amel2xC10.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1305826 {ECO:0000313|EMBL:SMF50468.1, ECO:0000313|Proteomes:UP000192930};
RN   [1] {ECO:0000313|EMBL:SMF50468.1, ECO:0000313|Proteomes:UP000192930}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Amel2xC10 {ECO:0000313|EMBL:SMF50468.1,
RC   ECO:0000313|Proteomes:UP000192930};
RA   Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA   Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FWZW01000008; SMF50468.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1X7FEK8; -.
DR   OrthoDB; 3862772at2; -.
DR   Proteomes; UP000192930; Unassembled WGS sequence.
DR   GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR016461; COMT-like.
DR   InterPro; IPR001077; O_MeTrfase_dom.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR43712:SF2; O-METHYLTRANSFERASE CICE; 1.
DR   PANTHER; PTHR43712; PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED; 1.
DR   Pfam; PF00891; Methyltransf_2; 1.
DR   PIRSF; PIRSF005739; O-mtase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51683; SAM_OMT_II; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000313|EMBL:SMF50468.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000192930};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000313|EMBL:SMF50468.1}.
FT   DOMAIN          122..328
FT                   /note="O-methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00891"
SQ   SEQUENCE   350 AA;  37709 MW;  A3E8423A1F56DC34 CRC64;
     MTTAQTAPPQ PPPASPPPSM RLRELAFGAA AAAALRAAAR LGVADALGER PTTVDDLAAA
     VKTEPRQLRR LLRALSCYGV FAERPDGTFA HTDVSRLLRE DDPHSLRAIT LWCTEPWTWD
     AWPKLDEAVR TGHNVVEDLY GKEFFVYLNE DAPESADVFN RAMTTSSVQS ARDVAEFLDL
     SGAASVADIG GGQGHVVASL LEKYPAMRGT LLDLPRVVEN ADARLREGGA LAGRVEVVPG
     DCRAAIPVQA DVYIIKNILE WDDESTARTL RNVIAAGGPG TRVVVIENLV DDTPSMRFST
     AMDLLLLLNV GGAKHTTDSM VSRLTEAGLV IDDIRPVNPY LHAFDCHVPA
//