ID A0A1X7FEU9_9ACTN Unreviewed; 1415 AA.
AC A0A1X7FEU9;
DT 05-JUL-2017, integrated into UniProtKB/TrEMBL.
DT 05-JUL-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Nonribosomal peptide synthetase MxcG {ECO:0000313|EMBL:SMF50921.1};
GN ORFNames=SAMN02745830_04072 {ECO:0000313|EMBL:SMF50921.1};
OS Streptomyces sp. Amel2xC10.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1305826 {ECO:0000313|EMBL:SMF50921.1, ECO:0000313|Proteomes:UP000192930};
RN [1] {ECO:0000313|EMBL:SMF50921.1, ECO:0000313|Proteomes:UP000192930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Amel2xC10 {ECO:0000313|EMBL:SMF50921.1,
RC ECO:0000313|Proteomes:UP000192930};
RA Afonso C.L., Miller P.J., Scott M.A., Spackman E., Goraichik I.,
RA Dimitrov K.M., Suarez D.L., Swayne D.E.;
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; FWZW01000008; SMF50921.1; -; Genomic_DNA.
DR OrthoDB; 2472181at2; -.
DR Proteomes; UP000192930; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 1.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR Pfam; PF00668; Condensation; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 1.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000192930}.
FT DOMAIN 916..991
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 1003..1024
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1384..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1415 AA; 151628 MW; CCAD75BB76B2B2C3 CRC64;
MNRPLLAAQE GIWAGQQLDT GSPAYNTAEY LRITGPLDPA VFDRALHHVV AETEALNVTF
HTDDTGRPRQ ITTPADAWRT HIADLTAEPD PHAAALAWMD QDMARPVDLT RGPVFGHALL
RTAPREFLWY HRVHHIALDG FGLSLVARRV AEVYTALMAG EPVPEGGFGT LDAVLAEERA
YRDSARHTAD RAYWTDRYAD DPPVVTPAGR SALPARTFHR QVTDLAPAAV RQLRTLAADM
TVTWSEVLLA VTVARLHRLT RAPEIVLGLP VTGRLGSAAL RVPATVRNIL PLRVPVTPDD
SLRVLAHRVA RELRSALPHQ RYRYEQLRRD LKRVGGGRRL SGTAVNIMPF AYDLTFAGHP
STVHNVSAGP VDDLAVNVYD RGDGTGLRVA VDANPELYTQ TETAAFRDGL LGLLTEALAD
PDSPLGEPRA PRAVTVLDGG PLPAPARPVL SLIADHAAHR GSAVAVEHAG NTLTYAQLCD
AAADIARGLA ARGVGRGDVV AVDLPRGADA VTTVLGVLMS GAAYRPVDSS TARLAADVAD
HTVFPLHGRP FASADTLTPP GPTDLAYVLH TSGSTGRPKG VAVGHAALAH FVAAATHRYG
LRREDRVLHF APLHFDTSVE EIFLTLCAGA TLVIRTDDMT ESVPRFLDAC ARSRITVLDL
PTAYWHEVAY AVSTGAATLP RDVRTVVIGG EPALPERVER WRAAVGTSIA LLNTYGPTEA
TVVATVADLH DPGLAAGDVP IGLPLPGTSA AVVDGELYLL GPTLADGYRP EVPDSVRFAP
LTALPDGPRA YRTGDLVRIG EDGRLRHLGR ADSEFKISGH RVQPAEVESA LLTHPRIREA
AVAGQVLPDG TRRLVAHVVA PAPVPSPAEV REHLRARVPA VLIPSAVEFV DRLPRTGTGK
IDRAALTEPR PRRTPSAGSP LERTVTGIWR AILGTDTVAV DDDVFDLGAQ SLQVIQAANR
LGVALGRDVK VAWLFQHPTA AALAGFLTDG GADDGPSPAA FLTDSRLDPG IRPGPGRAPR
PASAPRRILL TGATGFVGTH LLARLLADTE AEIVCTVRAP GVTAADARLR EALRHHGITL
DDSASARLTA LPADLALPDL GLPQGTSAEL AATCDAIFHN AASVSILRDY ATLRAANTES
TRQLLRLAAV NSTPLHYIST LSVAPPVGRR PEVPEAFLPP HGQLRHGYQQ SKWASERLLE
QAAERGLPVT VHRLGRVVGP ARTGHVNERD FLWSVLRAGI PEGIVPQLFE DEVWTPVDFV
AGCVVHLSLH TDPRSTGPVF NHATLPRVRL ADVYDWVREY GYPVRPLPPR HWRARMPRTS
DAAATTLAFL DSTDTDTDTD TDLTLGRIRA DRVRTALEGT GITCPPIDRA LFFRSLDHCV
RAGTLPAPSR PRTTAQQPGT HGHFAPTTAT EHISK
//
